2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione

Product Name: 2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione
CAS No.: 2924858-25-1
Chemical Name: 2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione
Synonyms: 2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(4-morpholinyl)-;2-(2,6-dioxopiperidin-3-yl)-5-(morpholin-4-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CBNumber: CB213921170
Molecular Formula: C17H17N3O5
Formula Weight: 343.33
MOL File: 2924858-25-1.mol

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2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione Property

Boiling point:: 643.7±55.0 °C(predicted)
Density: 1.460±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
solubility: DMSO: Soluble: = 10 mg/ml
form: Solid
pka: 10.83±0.40(predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 43028
Product name: PT-179
Purity: ≥98%
Packaging: 5mg
Price: $94
Updated: 2026/04/30

Cayman Chemical

Product number: 43028
Product name: PT-179
Purity: ≥98%
Packaging: 10mg
Price: $179
Updated: 2026/04/30

Cayman Chemical

Product number: 43028
Product name: PT-179
Purity: ≥98%
Packaging: 25mg
Price: $422
Updated: 2026/04/30

Cayman Chemical

Product number: 43028
Product name: PT-179
Purity: ≥98%
Packaging: 50mg
Price: $748
Updated: 2026/04/30

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2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione Chemical Properties,Usage,Production

Uses

PT-179 is an orthogonal Thalidomide (HY-14658) derivative that targets cereblon without causing off-target degradation effects. PT-179 is able to specifically bind CRBN, form a ternary complex with a target protein fused to a zinc finger (ZF) degron, and mediate the degradation of the tagged protein. For example, PT-179 binds to the ubiquitin ligase substrate receptor cereblon by forming a complex with SD40 and efficiently degrades proteins N- or C-terminally fused to SD40 or SD36 (DC50 for eGFP: 4.5 nM and 14.3 nM). PT-179 can be used to develop compact protein degradation tagging platforms[1].

IC 50

Cereblon

References

[1] Mercer JAM, et al. Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science. 2024 Mar 15;383(6688):eadk4422. DOI:10.1126/science.adk4422

2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione Suppliers

China 33 United States 1 Global 34

CHAUNGZERUI

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Nanjing Chemlin Chemical Co., Ltd

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Fax: +86-25-83453306
Email: info@chemlin.com.cn
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
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Shanghai Chaolan Chemical Technology Center

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Email: Sales@ATKchemical.com
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Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-28967200 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
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Jilin Province Woda Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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DC Chemicals

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Birdo (Shanghai) Medical Technology Co., Ltd.

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Email: sales@birdotech.com
Country: China
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Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd

Tel: 15317229551
Fax: QQ:3607245178
Email: 15151849396@163.com
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View Lastest Price from 2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione manufacturers

Hubei Chuchang Biotech Co., Ltd.

Product: PT-179 2924858-25-1
Price: US $500.00/MG
Min. Order: 1MG
Purity: 99
Supply Ability: 20G
Release date: 2024-06-03

2924858-25-1, 2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dioneRelated Search:

2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(4-morpholinyl)-

2-(2,6-dioxopiperidin-3-yl)-5-(morpholin-4-yl)-2,3-dihydro-1H-isoindole-1,3-dione

2924858-25-1