2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione
- Product Name
- 2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione
- CAS No.
- 2924858-25-1
- Chemical Name
- 2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione
- Synonyms
- 2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(4-morpholinyl)-;2-(2,6-dioxopiperidin-3-yl)-5-(morpholin-4-yl)-2,3-dihydro-1H-isoindole-1,3-dione
- CBNumber
- CB213921170
- Molecular Formula
- C17H17N3O5
- Formula Weight
- 343.33
- MOL File
- 2924858-25-1.mol
2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione Property
- Boiling point:
- 643.7±55.0 °C(predicted)
- Density
- 1.460±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
- solubility
- DMSO: Soluble: = 10 mg/ml
- form
- Solid
- pka
- 10.83±0.40(predicted)
- color
- Light yellow to yellow
2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione Chemical Properties,Usage,Production
Uses
PT-179 is an orthogonal Thalidomide (HY-14658) derivative that targets cereblon without causing off-target degradation effects. PT-179 is able to specifically bind CRBN, form a ternary complex with a target protein fused to a zinc finger (ZF) degron, and mediate the degradation of the tagged protein. For example, PT-179 binds to the ubiquitin ligase substrate receptor cereblon by forming a complex with SD40 and efficiently degrades proteins N- or C-terminally fused to SD40 or SD36 (DC50 for eGFP: 4.5 nM and 14.3 nM). PT-179 can be used to develop compact protein degradation tagging platforms[1].
IC 50
Cereblon
References
[1] Mercer JAM, et al. Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science. 2024 Mar 15;383(6688):eadk4422. DOI:10.1126/science.adk4422
2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione manufacturers
- Product
- PT-179 2924858-25-1
- Price
- US $500.00/MG
- Min. Order
- 1MG
- Purity
- 99
- Supply Ability
- 20G
- Release date
- 2024-06-03