tert-Butyl 3-bromopropylcarbamate

Product Name: tert-Butyl 3-bromopropylcarbamate
CAS No.: 83948-53-2
Chemical Name: tert-Butyl 3-bromopropylcarbamate
Synonyms: 3-(BOC-AMINO)PROPYL BROMIDE;(3-BROMO-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER;TERT-BUTYL N-(3-BROMOPROPYL)CARBAMATE;N-BOC-3-BROMOPROPYLAMINE;N-Boc 3-broMopropan-1-aMine;N-boc-3-aminopropyl bromide;3-(BOC-amino)propyl bromide,95%;TERT-BUTYL 3-BROMOPROPYLCARBAMATE;3-(Boc-amino)propyl bromide >=96.0% (GC);N-(TERT-BUTOXYCARBONYL)-3-BROMOPROPYLAMINE
CBNumber: CB2139373
Molecular Formula: C8H16BrNO2
Formula Weight: 238.12
MOL File: 83948-53-2.mol

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tert-Butyl 3-bromopropylcarbamate Property

Melting point:: 37-39 °C
Boiling point:: 285.3±23.0 °C(Predicted)
Density: 1.279±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Sparingly), Methanol (Slightly)
pka: 12.48±0.46(Predicted)
form: Low Melting Solid
color: White
BRN: 4176344
InChI: InChI=1S/C8H16BrNO2/c1-8(2,3)12-7(11)10-6-4-5-9/h4-6H2,1-3H3,(H,10,11)
InChIKey: IOKGWQZQCNXXLD-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NCCCBr
CAS DataBase Reference: 83948-53-2

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-24/25
WGK Germany: 3
F: 10-21
HS Code: 29241990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 17356
Product name: 3-(Boc-amino)propyl bromide
Purity: ≥96.0% (GC)
Packaging: 500mg
Price: $141
Updated: 2025/07/31

Sigma-Aldrich

Product number: 17356
Product name: 3-(Boc-amino)propyl bromide
Purity: ≥96.0% (GC)
Packaging: 2.5g
Price: $459
Updated: 2025/07/31

TCI Chemical

Product number: B2234
Product name: 3-(tert-Butoxycarbonylamino)propyl Bromide
Purity: >98.0%(T)
Packaging: 1g
Price: $184
Updated: 2025/07/31

TCI Chemical

Product number: B2234
Product name: 3-(tert-Butoxycarbonylamino)propyl Bromide
Purity: >98.0%(T)
Packaging: 5g
Price: $615
Updated: 2025/07/31

TRC

Product number: B690905
Product name: N-tert-Butoxycarbonyl-3-bromopropylamine
Packaging: 10g
Price: $1190
Updated: 2021/12/16

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tert-Butyl 3-bromopropylcarbamate Chemical Properties,Usage,Production

Chemical Properties

White low melting solid

Uses

3-(Boc-amino)propyl bromide can be used as an alkylating reagent for the synthesis of:

Benzydamine analogs to be used as activators for soluble guanylate cyclase.
N-substituted chromenotriazolopyrimidine, human murine double minute 2 (MDM2) inhibitor.
Protected amines from piperidine derivatives to be further used for synthesis of sulfonamide series.

It can also be used for the post-polymerization quaternization of polymers to synthesize functional cationic polymers and antimicrobial agents.

reaction suitability

reagent type: cross-linking reagent

Synthesis

24424-99-5

5003-71-4

83948-53-2

The general procedure for the synthesis of N-Boc-3-aminopropyl bromide from di-tert-butyl dicarbonate and 3-bromopropylamine hydrobromide is as follows: refer to Example 4, Synthesis of Boc-Aminopropyl Bromide: 1.222 g (5.58 mmol) of 3-bromopropylamine hydrobromide was dissolved in 20 mL of dichloromethane to which was added under cooling in an ice bath 0.778 mL (5.58 mmol) of triethylamine and 50 mL of dichloromethane. A solution of 1.214 g (5.56 mmol) of di-tert-butyl dicarbonate (Boc2O) was added slowly and dropwise over a period of 10 min, followed by stirring of the reaction mixture. After continued stirring at room temperature for 50 min, ethyl acetate was added to the reaction system and the organic phase was washed sequentially with 5% aqueous citric acid, water and saturated saline. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent to give 1.304 g of N-Boc-3-aminopropyl bromide in 98% yield. The structure of the product was confirmed by 1H-NMR. 1H-NMR (500 MHz, CDCl3) δ (ppm) = 1.44 (9H, s, Boc group), 2.05 (2H, quintet, -NHCH2CH2CH2Br), 3.28 (2H, quartet, -NHCH2CH2CH2Br), 3.44 ( 2H, triplet, -NHCH2CH2CH2Br), 4.64 (1H, s, NH).

References

[1] Patent: EP1710257, 2006, A1
[2] Chemical Communications, 2013, vol. 49, # 51, p. 5784 - 5786
[3] Patent: EP3363463, 2018, A2. Location in patent: Paragraph 0170
[4] Patent: WO2003/99858, 2003, A1. Location in patent: Page 37
[5] Journal of Organic Chemistry, 2003, vol. 68, # 26, p. 10058 - 10066

tert-Butyl 3-bromopropylcarbamate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 3-bromopropylcarbamate Suppliers

Americas 1 Belgium 1 CHINA 179 Europe 1 France 2 Germany 4 India 7 Italy 1 Japan 2 Switzerland 1 The Netherlands 1 United Kingdom 2 United States 32 Global 234

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View Lastest Price from tert-Butyl 3-bromopropylcarbamate manufacturers

Sach biotech Co.,Ltd

Product: tert-Butyl 3-bromopropylcarbamate 83948-53-2
Price: US $213.00-198.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 5mt
Release date: 2025-06-08

Henan Aochuang Chemical Co.,Ltd.

Product: tert-Butyl 3-bromopropylcarbamate 83948-53-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Jiangsu Nata Opto-electronic Material Co.,Ltd.

Product: 3-(Boc-amino)propylBromide 83948-53-2
Price: US $0.00/KG
Min. Order: 0.1KG
Purity: 98%
Supply Ability: 100kg
Release date: 2023-05-25

83948-53-2, tert-Butyl 3-bromopropylcarbamateRelated Search:

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N-(TERT-BUTOXYCARBONYL)-3-BROMOPROPYLAMINE

N-(3-BROMOPROPYL)CARBAMIC ACID TERT-BUTYL ESTER

N-BOC-3-BROMOPROPYLAMINE

TERT-BUTYL N-(3-BROMOPROPYL)CARBAMATE

3-(tert-Butoxycarbonylamino)propyl bromide

(3-BROMO-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER

3-(BOC-AMINO)PROPYL BROMIDE

TERT-BUTYL 3-BROMOPROPYLCARBAMATE

CarbaMic acid, N-(3-broMopropyl)-, 1,1-diMethylethyl ester

N-(3-Bromopropyl)carbamic Acid tert-Butyl Ester tert-Butyl N-(3-Bromopropyl)carbamate 3-(Boc-amino)propyl Bromide

CarbaMic acid, (3-broMopropyl)-, 1,1-diMethylethyl ester

N-Boc 3-broMopropan-1-aMine

3-(BOC-amino)propyl bromide,95%

tert-butyl N-(3-broManuidylpropyl)carbaMate

3-(Boc-amino)propyl bromide >=96.0% (GC)

3-(<i>tert</i>-Butoxycarbonylamino)propyl Bromide

N-boc-3-aminopropyl bromide

3-(tert-Butoxycarbonylamino)propyl Bromide &gt

83948-53-2

BrCH23NHCO2CCH33

C8H16BrNO2

Nitrogen Compounds

Organic Building Blocks

Protected Amines

Building Blocks