SANT-1

ChemicalBook > CAS DataBase List > SANT-1

Product Name: SANT-1
CAS No.: 304909-07-7
Chemical Name: SANT-1
Synonyms: SANT-1;CS-1685;SANT1 10MG;SANT1;SANT 1;SANT-1 USP/EP/BP;SANT-1; SANT1;SANT 1;SANT-1 - CAS 304909-07-7 - Calbiochem;SANT-1 (This product is only available in Japan.);SANT1,Smoothened,Hedgehog,Inhibitor,Smo,SANT-1,inhibit;(E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenylpyrazol-4-yl)methanimine
CBNumber: CB2141123
Molecular Formula: C23H27N5
Formula Weight: 373.49
MOL File: 304909-07-7.mol

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SANT-1 Property

Melting point:: 104-106°C
Boiling point:: 547.4±50.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO with warming
pka: 7.35±0.10(Predicted)
form: White solid
Sensitive: Moisture & Light Sensitive
CAS DataBase Reference: 304909-07-7

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S4572
Product name: SANT-1
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $190
Updated: 2024/03/01

Sigma-Aldrich

Product number: 559303
Product name: SANT-1
Packaging: 5mg
Price: $201
Updated: 2024/03/01

Alfa Aesar

Product number: J65294
Product name: SANT-1
Packaging: 10mg
Price: $169
Updated: 2023/06/20

Cayman Chemical

Product number: 14933
Product name: SANT 1
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 14933
Product name: SANT 1
Purity: ≥98%
Packaging: 5mg
Price: $107
Updated: 2024/03/01

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SANT-1 Chemical Properties,Usage,Production

Description

Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. SANT 1 is a potent inhibitor of hedgehog signaling that acts by directly antagonizing SMO (IC₅₀ = 20 nM). It counteracts SMO activation by the SMO agonist SAG but only partially competes with SAG binding to SMO. SANT 1 targets inactive SMO while it is in the cytoplasm, before it relocates to the primary cilium and is activated. Through antagonism of SMO, SANT 1 represses Gli-mediated transcription in a variety of cell types.

Chemical Properties

Pale Yellow Solid

Uses

Treatment of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells² and chronic lymphocytic leukemia cells³ with SANT-1 induced cell death.

Uses

A potent antagonist of the sonic hedgehog (Shh) signaling pathway (IC50=20nm inShh-LIGHT2 assay an d in Ptch1-/- cells) that acts by binding to smoothened (Smo: KD=1.2 nM), a distant relative of G protein-coupled receptors. In contrast to cyclopamine, SNAT-1 inhibits the activities of both wild type and oncogenic Smo with equal potency (IC50=30nm in SmoA1-LIGHT2 assay).

Definition

ChEBI: 1-(3,5-dimethyl-1-phenyl-4-pyrazolyl)-N-[4-(phenylmethyl)-1-piperazinyl]methanimine is a ring assembly and a member of pyrazoles.

Biological Activity

Potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (K D = 1.2 nM). Inhibits smoothened agonist effects with an IC 50 of 20 nM (in Shh-LIGHT2 cells).

Biochem/physiol Actions

SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist that directly inhibits by binding to the smoothened (Smo) receptor. SANT-1 inhibits wild type and oncogenic Smo with equal potency.

storage

Desiccate at +4°C

References

[1]. chen j k., taipale j, young k e,. small molecule modulation of smoothened activity. proc natl acad sci u s a, 2002, 99: 14071-6.
[2]. chun sg, zhou w & yee n s. combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer. cancer biol ther, 2009, 8: 1328-39.

SANT-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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SANT-1 Suppliers

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SANT1 10MG

SANT1;SANT 1

SANT-1 - CAS 304909-07-7 - Calbiochem

CS-1685

SANT-1; SANT1;SANT 1

SANT-1 (This product is only available in Japan.)

N-(4-Benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine

SANT-1 USP/EP/BP

SANT1,Smoothened,Hedgehog,Inhibitor,Smo,SANT-1,inhibit

304909-07-7

C23H27N5

Lipid signaling

Inhibitors

All Inhibitors

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