ChemicalBook > CAS DataBase List > Cyclobutyl bromide

Cyclobutyl bromide

Product Name
Cyclobutyl bromide
CAS No.
4399-47-7
Chemical Name
Cyclobutyl bromide
Synonyms
BROMOCYCLOBUTANE;obutane;Cyclobutyl halide;CYCLOBUTYL BROMIDE;Cyclobutane,bromo-;Cyclobutane, bromo-;Bromocyclobutane,95%;BroMocyclobutane 96%;Bromocyclobutane >Cyclobutylbromide,96%
CBNumber
CB2143132
Molecular Formula
C4H7Br
Formula Weight
135
MOL File
4399-47-7.mol
More
Less

Cyclobutyl bromide Property

Boiling point:
108 °C(lit.)
Density 
1.434 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.479(lit.)
Flash point:
72 °F
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Liquid
color 
Clear colorless
Water Solubility 
Insoluble
Sensitive 
Light Sensitive
BRN 
1900415
InChI
InChI=1S/C4H7Br/c5-4-2-1-3-4/h4H,1-3H2
InChIKey
KXVUSQIDCZRUKF-UHFFFAOYSA-N
SMILES
C1(Br)CCC1
CAS DataBase Reference
4399-47-7(CAS DataBase Reference)
NIST Chemistry Reference
Cyclobutyl bromide(4399-47-7)
More
Less

Safety

Hazard Codes 
Xi,Xn
Risk Statements 
10-36/37/38-20/21/22
Safety Statements 
26-36-36/37/39-16
RIDADR 
UN 1993 3/PG 2
WGK Germany 
3
F 
8
HazardClass 
3
PackingGroup 
II
HS Code 
29038900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
226998
Product name
Bromocyclobutane
Purity
96%
Packaging
1g
Price
$88.25
Updated
2025/07/31
Sigma-Aldrich
Product number
226998
Product name
Bromocyclobutane
Purity
96%
Packaging
5g
Price
$206
Updated
2025/07/31
TCI Chemical
Product number
C0771
Product name
Bromocyclobutane
Purity
>96.0%(GC)
Packaging
1g
Price
$33
Updated
2025/07/31
TCI Chemical
Product number
C0771
Product name
Bromocyclobutane
Purity
>96.0%(GC)
Packaging
5g
Price
$95
Updated
2025/07/31
TRC
Product number
B685023
Product name
Bromocyclobutane
Packaging
100mg
Price
$45
Updated
2021/12/16
More
Less

Cyclobutyl bromide Chemical Properties,Usage,Production

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

Cyclobutyl bromide is a cyclopentyl compound that has an hydroxyl group. It is a potent inhibitor of the CB2 receptor, which is primarily expressed on cells of the immune system. Cyclobutyl bromide has been shown to inhibit the uptake of uv light and also has anti-inflammatory properties. Studies have confirmed that this drug inhibits the production of cytokines and chemokines in chronic bronchitis patients, as well as other inflammatory diseases such as rheumatoid arthritis.

Synthesis

2516-33-8

4399-47-7

7051-34-5

The general procedure for the synthesis of cyclobutyl bromide and bromomethyl cyclopropane using hydroxymethyl cyclopropane as a starting material was as follows: first, a stirrer and thermometer were assembled on a 30 mL three-necked flask. 0.36 g (5.0 mmol) of hydroxymethylcyclopropane and 5 mL of chloroform were added to the flask, and the mixture was subsequently cooled to 10 °C with stirring. Then, 2.77 g (6.5 mmol) of a 19% hydrogen bromide/1,4-dioxane solution was slowly added dropwise. After the dropwise addition, the reaction mixture was heated to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, the reaction mixture was analyzed by gas chromatography (GC) to afford cyclobutyl bromide and bromomethyl cyclopropane in 74% overall yield. In addition, the reaction produced bromocyclobutane (9% yield) and 4-bromo-1-butene (2% yield) as isomers.

References

[1] Patent: JP2017/14124, 2017, A. Location in patent: Paragraph 0033
[2] European Journal of Medicinal Chemistry, 1980, vol. 15, # 6, p. 571 - 573
[3] Patent: JP5979791, 2016, B2. Location in patent: Paragraph 0036-0038; 0042-0052

Cyclobutyl bromide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Cyclobutyl bromide Suppliers

Americas 1 Belgium 2 China 199 Europe 4 France 2 Germany 7 India 12 Japan 4 Slovakia 3 Switzerland 3 United Kingdom 11 United States 35 Global 283
Hangzhou Rydberg Biotechnology Co., Ltd
Tel
13616542515
Email
3845715621@qq.com
Country
China
ProdList
158
Advantage
58
Chengdu Apis Pharmaceutical Technology Co.,Ltd
Tel
13568817957
Fax
028-66535130
Email
dudes@163.com
Country
China
ProdList
300
Advantage
58
Sichuan Weibo Science and Technology Co.,Ltd
Tel
028-65199188 13880582998
Fax
028-65199189
Email
ellnn@163.com
Country
China
ProdList
19
Advantage
58
Zhejiang zetian fine chemical co. LTD
Tel
0571-87322520 18957127338
Email
June@zetchem.com
Country
China
ProdList
382
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4267
Advantage
65
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
ZhengZhou HuaWen Chemical Co.Ltd
Tel
0370-2785118 17550508557
Fax
QQ：3470079902
Email
675141927@qq.com
Country
China
ProdList
3199
Advantage
55
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Lanzhou Hongsheng Fine Chemical Co., Ltd.
Tel
15693160370; 15693160393
Fax
028-37690518
Email
lzhschemical@163.com
Country
China
ProdList
58
Advantage
58
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Suzhou Sibian Chemical Technology Co.,Ltd.
Tel
0512-65617459 18915409046
Fax
0512-65617459
Email
sales@sibian-chem.com
Country
China
ProdList
1922
Advantage
55
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
SuZhou ShiYa Biopharmaceuticals, Inc.
Tel
86(512)5235 8471 17715136450
Fax
86(512)5235 6881
Email
sales@shiyabiopharm.com
Country
China
ProdList
4169
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Sichuan Weibo Science and Technology Co., Ltd.
Tel
028-87578473
Fax
+86 (28) 8757-8473
Email
ellnn@163.com
Country
China
ProdList
50
Advantage
60
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9546
Advantage
55
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4566
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Wuxi Zhangkun Biochemical Technology Co., Ltd.
Tel
+86 0510-85629785
Fax
+86 0510-85625359
Country
China
ProdList
2327
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9874
Advantage
55
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9979
Advantage
55
Zhengzhou HongSheng Pharmaceutical Co., Ltd.
Tel
0371-0371-13526885213 15637198702
Fax
0371-63709726
Email
hsyykjchem@163.com
Country
China
ProdList
3853
Advantage
58
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883
Fax
0731-82251112
Email
sales@huatengsci.com
Country
China
ProdList
5872
Advantage
58
NINGBO INNO PHARMCHEM CO.,LTD.
Tel
86-574-27787657
Fax
86-574-27912196
Email
info@dearchem.com
Country
China
ProdList
4613
Advantage
58
Credit-Chem Co., Ltd.
Tel
400-821-5857 021-64326257
Fax
021-64393586 QQ;2798200800
Email
credit-chem@foxmail.com
Country
China
ProdList
5219
Advantage
58
Tianjin Anhao Biological Technology Co., Ltd.
Tel
Email
sales@ahpharmatech.com
Country
China
ProdList
5734
Advantage
55
SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.
Tel
021-69106960 13701823733
Fax
021-69106780
Email
13701823733@163.com
Country
China
ProdList
4641
Advantage
60
More
Less

View Lastest Price from Cyclobutyl bromide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Cyclobutyl bromide 4399-47-7
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-22
Hebei Chuanghai Biotechnology Co., Ltd
Product
Cyclobutyl bromide 4399-47-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-12-02
GIHI CHEMICALS CO.,LIMITED
Product
Bromocyclobutane 4399-47-7
Price
US $10.00/bag
Min. Order
1bag
Purity
99
Supply Ability
100kg/week
Release date
2024-10-23

4399-47-7, Cyclobutyl bromideRelated Search:

ISOBUTANE Potassium bromide tert-Butyl methyl ether Sodium bromate Benzyl bromide Bromocyclopentane Tetrabutylammonium bromide Sodium bromide Hydrogen bromide Ethidium bromide Rocuronium bromide Cyclopropane butyl rubber 1-Bromobutane Allyl bromide n-Butane 1,2,5,6,9,10-Hexabromocyclododecane Phosphorus tribromide

  • BROMOCYCLOBUTANE
  • CYCLOBUTYL BROMIDE
  • Cyclobutylbromide,96%
  • Bromocyclobutane,95%
  • Cyclobutyl bromide, pure, 97%
  • Cyclobutane, bromo-
  • Cyclobutane,bromo-
  • Cyclobutyl bromide, 97%, pure
  • Cyclobutyl halide
  • Cyclobutyl bromideDISC 6/21/2000
  • Bromocyclobutane,Cyclobutyl bromide
  • BroMocyclobutane 96%
  • Bromocyclobutane &gt
  • obutane
  • Cyclobutyl bromide，Bromocyclobutane
  • Bromocyclobutane, 98% (Custom work)
  • 4399-47-7
  • HALOGEN
  • Organic Building Blocks
  • Simple 4-Membered Ring Compounds
  • Cyclobutanes & Cyclobutenes
  • Halogenated Hydrocarbons
  • Building Blocks
  • Alkyl
  • Pyridines ,Halogenated Heterocycles
  • Cyclobutanes & Cyclobutenes
  • Simple 4-Membered Ring Compounds
  • Cycloalkanes