ChemicalBook > CAS DataBase List > PHYLLANTHIN

PHYLLANTHIN

Product Name: PHYLLANTHIN
CAS No.: 10351-88-9
Chemical Name: PHYLLANTHIN
Synonyms: NSC 619043;PHYLLANTHIN;Phyllanthin-RM;Subfoliar Pearlin;Phyllanthin (15 mg);PHOSPHO-L-SERINE, O-(RG);Phyllanthin, 10 mM in DMSO;3,3',4,4',9,9'-HexaMethoxylignan;Tetra-O-Methylsecoisolariciresinol;(2S,3S)-(+)-1,4-Dimethoxy-2,3-diveratrylbutane
CBNumber: CB2143758
Molecular Formula: C24H34O6
Formula Weight: 418.52
MOL File: 10351-88-9.mol

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PHYLLANTHIN Property

Melting point:: 96℃
Boiling point:: 530.6±50.0 °C(Predicted)
Density: 1.069
storage temp.: 15-25°C
solubility: DMF: 15 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
form: Solid
color: White to off-white
BRN: 2066503
LogP: 4.110 (est)

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Safety

WGK Germany: 3
HS Code: 3824999270

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89756
Product name: Phyllanthin
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $524
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1536509
Product name: Phyllanthin
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 15mg
Price: $343
Updated: 2025/07/31

Sigma-Aldrich

Product number: 75110
Product name: Phyllanthin
Purity: analytical standard
Packaging: 10mg
Price: $408
Updated: 2022/05/15

Cayman Chemical

Product number: 11745
Product name: Phyllanthin
Purity: ≥98%
Packaging: 500μg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 11745
Product name: Phyllanthin
Purity: ≥98%
Packaging: 1mg
Price: $50
Updated: 2024/03/01

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PHYLLANTHIN Chemical Properties,Usage,Production

Uses

Phyllanthin is a chemical extract from the Phyllanthus niruri plant and displays pharmacological effects as an anti-diabetic action, anti-arthritic, and inhibitor of P-gp.

Definition

ChEBI: Phyllanthin is a lignan.

in vivo

Phyllanthin (10 mg/kg; oral administration; once a day; 30 days) has protective effects in carbon tetrachloride (HY-Y0298) induced hepatotoxicity and experimental liver fibrosis in mice ^[2].
Phyllanthin (30 mg/kg; oral administration; single dose) exerts anti-tumor effects in diethylnitrosamine (HY-N7434) induced liver carcinogenesis in rats ^[5].
Phyllanthin (20-100 mg/kg; oral administration; once a day; 14 days) inhibits cellular and humoral immune responses in Balb/C mice ^[6].

Animal Model:	Carbon tetrachloride (HY-Y0298) treated Swiss strain female mice (32-35 g) ^[2]
Dosage:	10 mg/kg
Administration:	Oral administration (p.o.); once a day; 30 days
Result:	Normalized the level of liver marker enzymes (ALT and AST) and collagen content in hepatotoxicity and experimental liver fibrosis mice. Restored normal liver architecture, reversed the formation of continuous fibrotic septa between the central and portal veins and nodules. Reduced the levels of TGF-β1, ALK5, p-Smad2 and p-Smad3 in hepatotoxicity and experimental liver fibrosis mice.

Animal Model:	Diethylnitrosamine (Cat. No. HY-N7434) treated male Wistar albino rats (210-230 g)^[5]
Dosage:	30 mg/kg
Administration:	Oral administration (p.o.); single dose
Result:	Significantly reduced 8-OHdG levels and delayed the oxidative damage in diethylnitrosamine -induced liver cancer rats. Significantly reduced liver tissue injury biomarkers (ALT, AST, GGT, ALP and LDH) levels and tumor markers (AFP and CEA). Reduced cellular enlargement, nodules, and hyperplasiaenlargement in diethylnitrosamine-induced liver tissue.

Animal Model:	Male Balb/C mice aged 6-8 weeks old (18-22 g) ^[6]
Dosage:	20 mg/kg, 40 mg/kg, and 100 mg/kg
Administration:	Oral administration (p.o.); once a day; 14 days
Result:	Dose-dependently inhibited CD11b/CD18 adhesion, the engulfment of E.coli by peritoneal macrophages molecules, NO and MPO release. Dose-dependently inhibited T and B lymphocytes proliferation and down-regulated Th1 (IL-2 and IFN-γ) and Th2 (IL-4) cytokines. Dose-dependently inhibited the sheep red blood cell (sRBC)-induced swelling rate of mice paw in delayed type hypersensitivity. Significantly inhibited the serum levels of ceruloplasmin and lysozyme at higher doses (40 and 100 mg/kg). Dose-dependently down-regulated anti-sRBC immunoglobulins (IgM and IgG) antibody titer.

PHYLLANTHIN Preparation Products And Raw materials

Raw materials

Preparation Products

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10351-88-9, PHYLLANTHINRelated Search:

Anwuligan Benzoylgomisin O (1S,3aR,4R,6aR)-4-(3,5-Dimethoxyphenyl)tetrahydro-1-(3,4,5-trimethoxyphenyl)-1H,3H-furo[3,4-c]furan 4'-Demethylepipodophyllotoxin HYPOPHYLLANTHIN 28-deMethyl -β-aMyrone B-D-GLUCOPYRANOSE 4'-Demethylpodophyllotoxin (-)-Syringaresinol-4-O-beta-D-glucopyranoside EUDESMINE CORILAGIN (-)-Syringaresnol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside Gomisin M2 conhydrine (S)-3-METHOXYPYRROLIDINE ETHOXYPYRROLIDINE(S-3-) PHYLLANTHIN 1-isopropylpiperidin-4-ol

PHYLLANTHIN

PHOSPHO-L-SERINE, O-(RG)

1,1'-[(2S,3S)-2,3-Bis(methoxymethyl)-1,4-butanediyl]bis[3,4-dimethoxybenzene]

NSC 619043

Phyllanthin (15 mg)

3,3',4,4',9,9'-HexaMethoxylignan

Tetra-O-Methylsecoisolariciresinol

(2S,3S)-(+)-1,4-Dimethoxy-2,3-diveratrylbutane

Subfoliar Pearlin

Benzene,1,1'-[(2S,3S)-2,3-bis(methoxymethyl)-1,4-butanediyl]bis[3,4-dimethoxy-

hepatoprotective,inhibit,bioactive,antioxidative,Phyllanthin,Phyllanthus,Inhibitor,amarus,lignan

Phyllanthin-RM

Phyllanthin, 10 mM in DMSO

10351-88-9