ChemicalBook > CAS DataBase List > 1,2-DIMETHOXY-4-FLUOROBENZENE

1,2-DIMETHOXY-4-FLUOROBENZENE

Product Name
1,2-DIMETHOXY-4-FLUOROBENZENE
CAS No.
398-62-9
Chemical Name
1,2-DIMETHOXY-4-FLUOROBENZENE
Synonyms
4-FLUORO-1,2-DIMETHOXYBENZENE;4-FLUOROVERATROLE;4-FLUOROVERATROLE 98%;4-Fluoroveratrole,98%;3,4-DIMETHOXYFLUOROBENZENE;3,4-Dimethoxyphenyl fluoride;1,2-DIMETHOXY-4-FLUOROBENZENE;1-FLUORO-3,4-DIMETHOXYBENZENE;3,4-DIMETHOXY-1-FLUOROBENZENE;1,2-Dimethoxy-4-fluorobenzene98%
CBNumber
CB2144922
Molecular Formula
C8H9FO2
Formula Weight
156.15
MOL File
398-62-9.mol
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1,2-DIMETHOXY-4-FLUOROBENZENE Property

Boiling point:
120-123°C 45mm
Density 
1.171 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.51(lit.)
Flash point:
197 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Oil
color 
Colourless
Specific Gravity
1.19
Water Solubility 
Soluble in water 0.079 g/L 25°C.
BRN 
2441600
InChI
InChI=1S/C8H9FO2/c1-10-7-4-3-6(9)5-8(7)11-2/h3-5H,1-2H3
InChIKey
DAGKHJDZYJFWSO-UHFFFAOYSA-N
SMILES
C1(OC)=CC=C(F)C=C1OC
CAS DataBase Reference
398-62-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39-24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29093090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
F0385
Product name
4-Fluoro-1,2-dimethoxybenzene
Purity
>97.0%(GC)
Packaging
5g
Price
$88
Updated
2025/07/31
TRC
Product number
D452798
Product name
1,2-Dimethoxy-4-fluorobenzene
Packaging
5g
Price
$65
Updated
2021/12/16
SynQuest Laboratories
Product number
2607-3-27
Product name
1,2-Dimethoxy-4-fluorobenzene
Purity
98%
Packaging
5G
Price
$35
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK157385
Product name
1,2-Dimethoxy-4-fluorobenzene
Purity
98%
Packaging
5g
Price
$61
Updated
2021/12/16
SynQuest Laboratories
Product number
2607-3-27
Product name
1,2-Dimethoxy-4-fluorobenzene
Purity
98%
Packaging
25g
Price
$95
Updated
2021/12/16
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1,2-DIMETHOXY-4-FLUOROBENZENE Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal

Uses

4-Fluoro-1,2-dimethoxybenzene is a raw material used in organic synthesis.

Synthesis

6315-89-5

398-62-9

General procedure for the synthesis of 4-fluoro-1,2-dimethoxybenzene from 3,4-dimethoxyaniline: 1. Continuous diazotization step: material A (50 mL containing 3,4-dimethoxyaniline (100 mmol), fluoboric acid (120 mmol), hydrochloric acid (180 mmol)) and material B (50 mL containing aqueous sodium nitrite solution) were mixed in a reaction tube at 25 °C with a residence time of about 15 seconds. Subsequently, sodium nitrite solution (105 mmol) was pumped into the reaction system through a T-fitting at a flow rate of 4 mL/min. The reaction mixture flowed out through the outlet and was collected in a cooling vessel, maintaining vigorous stirring during the process. The resulting slurry was cooled to -5°C and then pumped. The solids were washed with methanol and subsequently dried under vacuum to give the corresponding diazonium tetrafluoroborate. 2. Continuous fluorination carbonylation process: a slurry of the above prepared diazonium tetrafluoroborate in 300 mL of co-solvent was introduced continuously into the reaction tube at a flow rate of 4 mL/min. The mixture was kept at a set temperature for 1 min and subsequently cooled in the tandem tube. The collected liquid was washed with aqueous NaOH and water to give an almost colorless liquid of 4-fluoro-1,2-dimethoxybenzene.

References

[1] Tetrahedron Letters, 2013, vol. 54, # 10, p. 1261 - 1263
[2] Patent: CN105503549, 2016, A. Location in patent: Paragraph 0018; 0019; 0020
[3] Journal of Organic Chemistry, 1986, vol. 51, # 21, p. 4073 - 4075
[4] Angewandte Chemie - International Edition, 2018, vol. 57, # 31, p. 9896 - 9900
[5] Angew. Chem., 2018, vol. 130, p. 10044 - 10048,5

1,2-DIMETHOXY-4-FLUOROBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,2-DIMETHOXY-4-FLUOROBENZENE Suppliers

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View Lastest Price from 1,2-DIMETHOXY-4-FLUOROBENZENE manufacturers

Honest Joy Holdings Limited
Product
1,2-Dimethoxy-4-fluorobenzene 398-62-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98.1%
Supply Ability
100 tons
Release date
2022-02-20
Career Henan Chemical Co
Product
1,2-DIMETHOXY-4-FLUOROBENZENE 398-62-9
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
as request
Release date
2018-12-24

398-62-9, 1,2-DIMETHOXY-4-FLUOROBENZENERelated Search:

1,2-DIMETHOXY-4-FLUOROBENZENE 1,2-DIFLUORO-4,5-DIMETHOXYBENZENE 6-FLUOROVERATRALDEHYDE 2',4'-DIMETHOXY-2,2,2-TRIFLUOROACETOPHENONE 1,4-DIMETHOXY-2-FLUOROBENZENE,2,5-DIMETHOXY-1-FLUOROBENZENE,1,4-Dimethoxy-2-fluorobenzene 98%,1,4-Dimethoxy-2-fluorobenzene98% 1,4-DIFLUORO-2,5-DIMETHOXYBENZENE 2,4-DIMETHOXY-1-FLUOROBENZENE 1,3-DIMETHOXY-5-FLUOROBENZENE Fluorobenzene 4,5-DIMETHOXY-2-FLUOROBENZYL CHLORIDE 4,5-DIMETHOXY-2-FLUOROBENZONITRILE 3,4-DIMETHOXY-6-FLUOROCINNAMIC ACID 5,6,7,8-TETRAFLUOROBENZO-1,4-DIOXANE (2-FLUORO-4,5-DIMETHOXYPHENYL)-(R)-HYDROXYACETONITRILE 2,3-DIMETHOXY-1-FLUOROBENZENE 2-BROMO-3,5-DIMETHOXY-1-FLUOROBENZENE,2-Bromo-3,5-dimethoxy-1-fluorobenzene 98%,2-Bromo-3,5-dimethoxy-1-fluorobenzene98% RARECHEM AL BF 0312 RARECHEM AN KA 0413

  • 4-FLUORO-1,2-DIMETHOXYBENZENE
  • 3,4-DIMETHOXY-1-FLUOROBENZENE
  • 3,4-DIMETHOXYFLUOROBENZENE
  • 1-FLUORO-3,4-DIMETHOXYBENZENE
  • 1,2-DIMETHOXY-4-FLUOROBENZENE
  • 1,2-Dimethoxy-4-fluorobenzene 98%
  • 1,2-Dimethoxy-4-fluorobenzene98%
  • 4-Fluoropyrocatechol dimethyl ether
  • 4-FLUOROVERATROLE 98%
  • 3,4-Dimethoxyfluorobenzene (4-Fluoroveratrole)
  • 3,4-Dimethoxyphenyl fluoride
  • 4-Fluoroveratrole,98%
  • Benzene, 4-fluoro-1,2-diMethoxy-
  • 4-FLUOROVERATROLE
  • 4-Fluoro-1,2-dimethoxybenzene, 97+%(GC)
  • 398-62-9
  • FC6H312OCH32
  • Building Blocks
  • Ethers
  • Organic Building Blocks
  • Oxygen Compounds
  • Fluorine series
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Fluorine Compounds