2-Methoxycarbonylindole-5-boronicacid

Product Name: 2-Methoxycarbonylindole-5-boronicacid
CAS No.: 284660-86-2
Chemical Name: 2-Methoxycarbonylindole-5-boronicacid
Synonyms: 2-Methoxycarbonylindole-5-boronicacid;[2-(Methoxycarbonyl)-1H-indol-5-yl]boronic acid;1H-Indole-2-carboxylic acid, 5-borono-, 2-methyl ester;methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-2-carboxylate
CBNumber: CB21450813
Molecular Formula: C10H10BNO4
Formula Weight: 219
MOL File: 284660-86-2.mol

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2-Methoxycarbonylindole-5-boronicacid Property

Boiling point:: 484.2±48.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 8.55±0.30(Predicted)
Appearance: Light yellow to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: BOR0005721
Product name: 2-METHOXYCARBONYLINDOLE-5-BORONIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $502.01
Updated: 2021/12/16

AK Scientific

Product number: 2795AB
Product name: 2-Methoxycarbonylindole-5-boronicacid
Packaging: 250mg
Price: $579
Updated: 2021/12/16

Matrix Scientific

Product number: 096362
Product name: 2-Methoxycarbonylindole-5-boronic acid
Purity: 95+%
Packaging: 250mg
Price: $591
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0005721
Product name: 2-METHOXYCARBONYLINDOLE-5-BORONIC ACID
Purity: 95.00%
Packaging: 1G
Price: $1274.7
Updated: 2021/12/16

Matrix Scientific

Product number: 096362
Product name: 2-Methoxycarbonylindole-5-boronic acid
Purity: 95+%
Packaging: 1g
Price: $1311
Updated: 2021/12/16

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2-Methoxycarbonylindole-5-boronicacid Chemical Properties,Usage,Production

Synthesis

284660-89-5

111-42-2

284660-86-2

General procedure for the synthesis of (2-(methoxycarbonyl)-1H-indol-5-yl)boronic acid from methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-2-carboxylate and diethanolamine: 1. 391.2 mg (1.3 mmol) of methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-2-carboxylate was dissolved in ethyl acetate (EtOAc). 2. 0.25 mL (2.6 mmol) of diethanolamine was added to the solution and the reaction mixture was stirred overnight at room temperature. 3. Upon completion of the reaction, the white precipitate formed was collected by filtration. 4. The white precipitate was sonicated in 1N hydrochloric acid (HCl). 5. The treated white precipitate was again collected by filtration and dissolved in methanol (MeOH). 6. The methanol solution was concentrated in vacuum to afford the target product (2-(methoxycarbonyl)-1H-indol-5-yl)boronic acid with a recovery of 36.6 mg (13% yield). Product Characterization: HPLC retention time (Rf) = 13.912 min. 1H NMR (DMSO-d6, δ): 3.85 (s, 3H), 7.15 (s, 1H), 7.36 (d, J = 8.4 Hz, 1H), 7.67 (d, J = 8.4 Hz, 1H), 7.87 (s, 1H), 8.14 (s, 1H), 11.91 (s, 1H).

References

[1] Patent: US2008/4241, 2008, A1. Location in patent: Page/Page column 140-141

2-Methoxycarbonylindole-5-boronicacid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methoxycarbonylindole-5-boronicacid Suppliers

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284660-86-2, 2-Methoxycarbonylindole-5-boronicacidRelated Search:

2-Methoxycarbonylindole-5-boronicacid

[2-(Methoxycarbonyl)-1H-indol-5-yl]boronic acid

methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-2-carboxylate

1H-Indole-2-carboxylic acid, 5-borono-, 2-methyl ester

284660-86-2

C10H10BNO4