N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine

Product Name: N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine
CAS No.: 129639-79-8
Chemical Name: N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine
Synonyms: Abafungin;BAY-W 6341;UNII-11DI31LWXF;inhibit,Fungal,Abafungin,Inhibitor;N-[4-[2-(2,4-Dimethylphenoxy)phenyl]-2-thiazolyl]-1,4,5,6-tetrahydro-2-pyrimidinamine;4-(2-(2,4-dimethylphenoxy)phenyl)-N-(1,4,5,6-tetrahydropyrimidin-2-yl)thiazol-2-amine;2-Pyrimidinamine, N-[4-[2-(2,4-dimethylphenoxy)phenyl]-2-thiazolyl]-1,4,5,6-tetrahydro-;N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine
CBNumber: CB21454280
Molecular Formula: C21H22N4OS
Formula Weight: 378.49
MOL File: 129639-79-8.mol

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N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine Property

Melting point:: 199 °C
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMF: 10 mg/mL; DMSO: 2.5 mg/mL; Ethanol: 0.3 mg/mL; PBS (pH 7.2): 0.3 mg/mL
form: powder to crystal
color: White to Light yellow

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Safety

HS Code: 2934.10.2000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A3213
Product name: Abafungin
Packaging: 50MG
Price: $161
Updated: 2024/03/01

TCI Chemical

Product number: A3213
Product name: Abafungin
Packaging: 250MG
Price: $539
Updated: 2024/03/01

TRC

Product number: A107228
Product name: Abafungin
Packaging: 100mg
Price: $1470
Updated: 2021/12/16

Chem-Impex

Product number: 28441
Product name: Abafungin,95%(HPLC)
Purity: 95%(HPLC)
Packaging: 5G
Price: $2234.4
Updated: 2021/12/16

AK Scientific

Product number: 6067AH
Product name: Abafungin
Packaging: 1g
Price: $685
Updated: 2021/12/16

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N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine Chemical Properties,Usage,Production

Originator

Abafungin,York Pharma

Uses

Abafungin is a broad-spectrum antifungal agent.

Definition

ChEBI: A member of the class of guanidines that is tetrahydropyrimidin-2(1H)-imine in which the hydrogen of the imino group is replaced by a thiazol-2-yl group which in turn is substituted by a 2-(2,4-dimethylphenoxy)phenyl group at position 4 It has been used for the topical treatment of fungal nail infections.

Manufacturing Process

15.8 g (0.12 mole) N-(1,4,5,6-tetrahydropyrimidinyl)thiourea were added to 27.45 g (0.1 mole) 2-(2,4-dimethylphenoxy)phenacyl chloride in 100 ml acetone and heated to reflux for 2 hours. On cooling the falling out product was filtered off, washed with acetone and dried. N-[4-[2-(2,4- Dimethylphenoxy)phenyl]-2-thiazolyl]-1,4,5,6-tetrahydro-2-pyrimidinamine hydrochloride was prepared. Yield 91.4%; MP: 160°C.
20.72 g (0.05 mole) above product was stirred with 300 ml 1 N sodium hydroxide for 30 minutes at room temperature. The insoluble product was filtered off, washed and dried. Yield of N-[4-[2-(2,4-dimethylphenoxy)phenyl]- 2-thiazolyl]-1,4,5,6-tetrahydro-2-pyrimidinamine was 16.2 g (86%). MP: 191°-192°C.

Therapeutic Function

Antibacterial, Antifungal

N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine Suppliers

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View Lastest Price from N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine manufacturers

Career Henan Chemical Co

Product: N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine 129639-79-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: KG/T
Release date: 2019-12-17

129639-79-8, N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amineRelated Search:

N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine 2-(2-Amino-thiazol-4-yl)-phenol 4-(2-METHOXY-PHENYL)-THIAZOL-2-YLAMINE

N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine

Abafungin

BAY-W 6341

4-(2-(2,4-dimethylphenoxy)phenyl)-N-(1,4,5,6-tetrahydropyrimidin-2-yl)thiazol-2-amine

N-[4-[2-(2,4-Dimethylphenoxy)phenyl]-2-thiazolyl]-1,4,5,6-tetrahydro-2-pyrimidinamine

2-Pyrimidinamine, N-[4-[2-(2,4-dimethylphenoxy)phenyl]-2-thiazolyl]-1,4,5,6-tetrahydro-

UNII-11DI31LWXF

inhibit,Fungal,Abafungin,Inhibitor

129639-79-8