ChemicalBook > CAS DataBase List > N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide

N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide

Product Name
N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide
CAS No.
178870-32-1
Chemical Name
N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide
Synonyms
Nsc675186;Aids029940;Aids-029940;Thiocarboxanilide;N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide;N-[4-Chloro-3-(3-methyl-2-butenyloxy)phenyl]-2-methyl-3-furancarbothioamide;3-Furancarbothioamide, N-[4-chloro-3-[(3-methyl-2-buten-1-yl)oxy]phenyl]-2-methyl-
CBNumber
CB21455999
Molecular Formula
C17H18ClNO2S
Formula Weight
335.85
MOL File
178870-32-1.mol
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N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide Property

Boiling point:
440.9±55.0 °C(Predicted)
Density 
1.240±0.06 g/cm3(Predicted)
pka
9.78±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
HCH0140600
Product name
N-(4-CHLORO-3-[(3-METHYLBUT-2-EN-1-YL)OXY]PHENYL)-2-METHYLFURAN-3-CARBOTHIOAMIDE
Purity
95.00%
Packaging
5MG
Price
$500.67
Updated
2021/12/16
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N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide Chemical Properties,Usage,Production

Uses

UC-781 (NSC 675186) is a highly potent and selective nonnucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 with an IC50 value of 5 nM. UC-781 is stable under low PH or various temperatures conditions. UC-781 has antiviral activity and resistance[1][2][3].

in vivo

UC-781 (100 μl 5% UC-781 replens gel; intravaginal; once daily for 10 days) releases from gel preparation and shows low toxicity to normal tissues in female rabbit[1].

Animal Model:Female rabbit (~1200 g; 10 weeks old)[1].
Dosage:100 μl 5% UC-781 replens gel.
Administration:Intravaginal; once daily for 10 days.
Result:Released from gel preparation and had normal histology without significant increases inflammatory cells in rabbits.

IC 50

HIV-1: 0.005 μM (IC50)

References

[1] Balzarini J, et al. Preclinical studies on thiocarboxanilide UC-781 as a virucidal agent. AIDS. 1998 Jul 9;12(10):1129-38. DOI:10.1097/00002030-199810000-00004
[2] Van Herrewege Y, et al. In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides. Antimicrob Agents Chemother. 2004 Jan;48(1):337-9. DOI:10.1128/AAC.48.1.337-339.2004
[3] Balzarini J, et al. Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication. Mol Pharmacol. 1996 Aug;50(2):394-401. PMID:8700148
[4] Fletcher P, et al. The nonnucleoside reverse transcriptase inhibitor UC-781 inhibits human immunodeficiency virus type 1 infection of human cervical tissue and dissemination by migratory cells. J Virol. 2005 Sep;79(17):11179-86. DOI:10.1128/JVI.79.17.11179-11186.2005

N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide Suppliers

China 9 United States 2 Global 11
SPIRO PHARMA
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TargetMol Chemicals Inc.
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TargetMol Chemicals Inc.
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TargetMol Chemicals Inc.
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178870-32-1, N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamideRelated Search:

(2-METHYL-3-FURYL)METHYLAMINE N-Methyl(2-methyl-3-furyl)methylamine 4-Chloro-3-ethoxyaniline 3-FURANCARBOTHIOAMIDE 1-(3-FURYL)METHANAMINE HYDROCHLORIDE N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide

  • N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide
  • Aids029940
  • Aids-029940
  • N-[4-Chloro-3-(3-methyl-2-butenyloxy)phenyl]-2-methyl-3-furancarbothioamide
  • Nsc675186
  • Thiocarboxanilide
  • 3-Furancarbothioamide, N-[4-chloro-3-[(3-methyl-2-buten-1-yl)oxy]phenyl]-2-methyl-
  • 178870-32-1