(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE
- Product Name
- (2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE
- CAS No.
- 29734-68-7
- Chemical Name
- (2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE
- Synonyms
- DHβE hydrobromide;DHβE hydrobromide;Dihydro-b-erythroidi;-erythroidineHydrobromide;-erythroidine hydrobromide;Dihydro-2-erythroidine Hydrobromide;DIHYDRO-B-ERYTHROIDINE HYDROBROMIDE;Dihydro-β-erythroidine hydrobromide;Dihydro-β-erythroidine hydrobromide;DIHYDRO-BETA-ERYTHROIDINE HYDROBROMIDE
- CBNumber
- CB2145747
- Molecular Formula
- C16H21NO3.BrH
- Formula Weight
- 356.25
- MOL File
- 29734-68-7.mol
(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE Property
- storage temp.
- Desiccate at RT
- solubility
- ethanol: 5mg/mL
- form
- solid
- Melting point:
- 219-229 °C (decomp)
- color
- white
Safety
- Safety Statements
- 22-36
- WGK Germany
- 3
- RTECS
- KF3325000
N-Bromosuccinimide Price
- Product number
- 2349
- Product name
- Dihydro-b-erythroidinehydrobromide
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $214
- Updated
- 2021/12/16
- Product number
- 2349
- Product name
- Dihydro-b-erythroidinehydrobromide
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $891
- Updated
- 2021/12/16
- Product number
- D452485
- Product name
- Dihydro-β-erythroidineHydrobromide
- Packaging
- 0.5mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- B7030
- Product name
- Dihydro-β-erythroidinehydrobromide
- Packaging
- 50mg
- Price
- $1284
- Updated
- 2021/12/16
- Product number
- B7030
- Product name
- Dihydro-β-erythroidinehydrobromide
- Packaging
- 10mg
- Price
- $308
- Updated
- 2021/12/16
(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE Chemical Properties,Usage,Production
Uses
Dihydro-β-erythroidine is an alkaloid isolated from the seeds of erythrina and a competitive antagonist at the nicotinic acetylcholine receptor (nAChR).
Definition
ChEBI: Dihydro-beta-erythroidine hydrobromide is a member of indoles.
Biological Activity
Competitive nicotinic acetylcholine receptor antagonist with moderate selectivity for the neuronal α 4 receptor subunit (IC 50 values are 0.19 and 0.37 μ M for α 4 β 4 and α 4 β 2 receptors respectively). Antagonizes behavioral effects of nicotine in vivo .
in vitro
dhβe has been shown to be a purely competitive antagonist of the neuronal nicotinic receptor [1].
in vivo
dhβe is able to block some of the central actions of nicotine after systemic and intrathecal administration. the mechanism of blockade is different from that of mecamylamine, a classical ganglionic antagonist, and may involve a direct action of dhβe on nicotine receptor [2].
IC 50
1.3 μm for α2β2, 2.3 μm for α2β4, 0.41 μm for α3β2, 23.1 μm for α3β4, 0.37 μm for α4β2, and 0.19 μm for α4β4 [1]
storage
Desiccate at RT
References
[1] harvey sc, maddox fn, luetje cw. multiple determinants of dihydro-beta-erythroidine sensitivity on rat neuronal nicotinic receptor alpha subunits. j neurochem. 1996 nov;67(5):1953-9.
[2] damaj mi, welch sp, martin br. in vivo pharmacological effects of dihydro-beta-erythroidine, a nicotinic antagonist, in mice. psychopharmacology (berl). 1995 jan;117(1):67-73.
[3] murphree hb. effects in human volunteers of subparalytic doses of dihydro-beta-erythroidine. clin pharmacol ther. 1963 may-jun;4:304-10.
(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE Suppliers
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