Ethyl N-Cbz-4-Oxopyrrolidine-3-carboxylate
- Product Name
- Ethyl N-Cbz-4-Oxopyrrolidine-3-carboxylate
- CAS No.
- 51814-19-8
- Chemical Name
- Ethyl N-Cbz-4-Oxopyrrolidine-3-carboxylate
- Synonyms
- 1-benzyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate;Ethyl N-Cbz-4-Oxopyrrolidine-3-carboxylate;Ethyl 1-Cbz-4-oxopyrrolidine-3-carboxylate;ETHYL 1-N-CBZ-4-OXO-PYRROLIDINE-3-CARBOXYLATE;1-Cbz-4-oxo-3-Pyrrolidinecarboxylic acid ethyl ester;Ethyl 1-Cbz-4-oxopyrrolidine-3-carboxylate - [E14671];1-O-benzyl 3-O-ethyl 4-oxopyrrolidine-1,3-dicarboxylate;Ethyl N-benzyloxycarbonyl-4-oxopyrrolidine-3-carboxylate, 97%;4-Oxopyrrolidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester;1,3-Pyrrolidinedicarboxylic acid, 4-oxo-, 3-ethyl 1-(phenylmethyl) ester
- CBNumber
- CB21459654
- Molecular Formula
- C15H17NO5
- Formula Weight
- 291.3
- MOL File
- 51814-19-8.mol
Ethyl N-Cbz-4-Oxopyrrolidine-3-carboxylate Property
- Boiling point:
- 433.1±45.0 °C(Predicted)
- Density
- 1.273±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- pka
- 11.17±0.20(Predicted)
- Appearance
- White to off-white Solid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- E930568
- Product name
- EthylN-Cbz-4-oxopyrrolidine-3-carboxylate
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- E14671
- Product name
- Ethyl1-Cbz-4-oxopyrrolidine-3-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- FB32833
- Product name
- 1-Benzyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- J50934
- Product name
- 1-Benzyl3-ethyl4-oxopyrrolidine-1,3-dicarboxylate
- Packaging
- 5g
- Price
- $108
- Updated
- 2021/12/16
- Product number
- 057291
- Product name
- 1-Benzyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $87
- Updated
- 2021/12/16
Ethyl N-Cbz-4-Oxopyrrolidine-3-carboxylate Chemical Properties,Usage,Production
Synthesis
51814-17-6
51814-19-8
Ethyl 3-[N-benzyloxycarbonyl-N-(ethoxycarbonylmethyl)amino]propanoate (26.8 g, 79.5 mmol) was used as a raw material and dissolved in ethanol (200 mL). To this solution was added an ethanolic solution of 20% sodium ethanolate (40.6 mL, 119.3 mmol), followed by heating and refluxing the reaction mixture for 2 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure and the residue was dissolved in water (100 mL). The aqueous solution was acidified by slowly adding concentrated hydrochloric acid to the aqueous solution under cooling in an ice bath and extracted with chloroform (100 mL x 3) after acidification. The chloroform extracts were combined, washed with saturated aqueous sodium chloride solution (100 mL) and then dried with anhydrous sodium sulfate. After drying, the filtrate was filtered and the filtrate was concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate, 2:1) to give 16.7 g of ethyl N-Cbz-4-oxo-3-pyrrolidinecarboxylate in 72% yield as a light brown oil. The product was characterized by 1H-NMR (400 MHz, CDCl3) and MS (ESI): 1H-NMR δppm: 1.25-1.33 (3H, m), 3.87-4.37 (7H, m), 5.16-5.22 (2H, m), 7.23-7.41 (5H, m); MS (ESI) m/z: 314 (M + Na) + . .
References
[1] Patent: US2006/264428, 2006, A1. Location in patent: Page/Page column 47-48
[2] Patent: WO2006/123792, 2006, A1. Location in patent: Page/Page column 109-110
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 5, p. 1273 - 1277
[4] Patent: EP1992613, 2008, A1. Location in patent: Page/Page column 12
[5] Archiv der Pharmazie, 2008, vol. 341, # 12, p. 780 - 786
Ethyl N-Cbz-4-Oxopyrrolidine-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl N-Cbz-4-Oxopyrrolidine-3-carboxylate manufacturers
- Product
- Ethyl N-Cbz-4-Oxopyrrolidine-3-carboxylate 51814-19-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99.8%
- Supply Ability
- 100000kgs
- Release date
- 2024-08-23
- Product
- Ethyl N-Cbz-4-Oxopyrrolidine-3-carboxylate 51814-19-8
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2020-04-27
- Product
- 1-Benzyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate 51814-19-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 100g
- Purity
- 99%+
- Supply Ability
- 10 tons
- Release date
- 2019-12-27