N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)

Product Name: N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)
CAS No.: 1477-57-2
Chemical Name: N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)
Synonyms: SKL878;r-010-tk;win18441;win18446;win18,446;NSC 59354;bisdiamine;FERTILYSIN;bis-diamine;Fertilysine
CBNumber: CB2146249
Molecular Formula: C12H20Cl4N2O2
Formula Weight: 366.11
MOL File: 1477-57-2.mol

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N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) Property

Melting point:: 118-120 °C
Boiling point:: 530℃
Density: 0.726
refractive index: 1.6200 (estimate)
Flash point:: 275℃
storage temp.: Inert atmosphere,2-8°C
solubility: Acetone (Very Slightly), DMSO (Slightly), Methanol (Sparingly, Heated, Sonicated
pka: 12.28±0.46(Predicted)
form: Solid
color: White to Off-White
CAS DataBase Reference: 1477-57-2

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-40
Safety Statements: 24/25-45-36
Toxicity: LD50 orally in mice: >16000 mg/kg (Coulston)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H351Suspected of causing cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3187
Product name: WIN 18446
Purity: ≥98% (HPLC)
Packaging: 50MG
Price: $123
Updated: 2024/03/01

Cayman Chemical

Product number: 14018
Product name: WIN 18,446
Purity: ≥98%
Packaging: 50mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 14018
Product name: WIN 18,446
Purity: ≥98%
Packaging: 100mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 14018
Product name: WIN 18,446
Purity: ≥98%
Packaging: 250mg
Price: $151
Updated: 2024/03/01

Tocris

Product number: 4736
Product name: WIN18446
Packaging: 50
Price: $125
Updated: 2021/12/16

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N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

Win 18446 was shown to inhibit the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis and in the embryonic murine gonad.

Definition

ChEBI: A carboxamide that is 1,8-diaminooctane in which a hydrogen attached to each of the amino groups has been replaced by a dichloroacetyl group. Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2). Inhibits the biosynthesis of retinoic acid from retinol in neon tal and adult murine testis. It down-regulates sex related genes in zebrafish.

Biological Activity

win 18446 is a bis-(dichloroacetyl)-diamine which inhibits aldehyde dehydrogenase 1a2 (aldh1a2), with ic50 value of 300 nm [1].aldh1a2, expressed almost exclusively in the testes, localizes to developing germ cells within the seminiferous tubules and strongly binds retinol, but does not recognize acetaldehyde as a substrate, suggesting that aldh1a2 functions in testicular retinoic acid biosynthesis [1].in whole testes or germ cells isolated from mice at 2 days postpartum, win 18,446 alone (1 μm) or in combination with retinol significantly reduced the expression of stra8, a marker for retinoic acid activity [2].in male rabbits, oral administration of win 18446 at 200 mg/kg for 16 weeks substantially reduced intratesticular concentrations of retinoic acid, significantly impaired spermatogenesis, and resulted in infertility. reduced concentrations of intratesticular retinoic acid became obvious after only 4 weeks of treatment and preceded the decrease in sperm counts and the loss of mature germ cells in tissue samples. sperm counts and fertility recovered after treatment was discontinued [1].[1]. amory j k, muller c h, shimshoni j a, et al. suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. journal of andrology, 2011, 32(1): 111-119.[2]. hogarth c a, evanoff r, snyder e, et al. suppression of stra8 expression in the mouse gonad by win 18,446. biology of reproduction, 2011, 84(5): 957-965.

Safety Profile

Poison by intraperitoneal route.Human systemic effects by ingestion: nausea andvomiting. Human reproductive effects by ingestion:changes in spermatogenesis. An experimental teratogen.Other experimental reproductive effects. Human mutationdata reporte

storage

Store at +4°C

N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) Preparation Products And Raw materials

Raw materials

Preparation Products

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N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) Suppliers

Canada 1 China 69 Europe 1 Germany 2 India 3 Japan 1 Slovakia 1 United Kingdom 5 United States 15 Global 98

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View Lastest Price from N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) 1477-57-2
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2024-07-26

1477-57-2, N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)Related Search:

BUTYLAMINE HYDROCHLORIDE Allylamine hydrochloride N-Ethylacetamide OCTYLAMINE HYDROCHLORIDE DICHLOROACETALDEHYDE HYDRATE N,N'-DIMETHYL-1,8-OCTANEDIAMINE 2-Chloro-N-methylacetamide N-Methylacetamide N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) N-METHYLHEXYLAMINE N-METHYLBUTYLAMINE N-PROPYLAMINE HYDROCHLORIDE N-Methylethylamine hydrochloride Diethylamine N-Ethylmethylamine Hexylamine N-HEXYLAMINE HYDROCHLORIDE Ethylbutylamine

FERTILYSIN

N,N'-BIS(DICHLOROACETYL)-1,8-OCTAMETHYLENEDIAMINE

N,N'-OCTA-METHYLENE-BIS[2,2-DICHLOROACETAMIDE]

N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)

bisdiamine

bis-diamine

n,n’,1,8-octanediylbis(2,2-dichloro-acetamid

n,n’-bis(dichloroacetyl)-1,8-diaminooctane

n,n’-bis(dichloroacetyl)-1,8-octanediamine

n,n’-octamethylenebis(2,2-dichloro-acetamid

n,n’-octamethylenebis(2,2-dichloroactamide)

n,n-bis(dichloroacetyl)-1,8-octanediamine

r-010-tk

win18,446

win18441

win18446

NSC 59354

N,N''-OCTMETHYLENEBIS (DICHLOROACETAMIDE)

N,N'-(1,8-Octanediyl)bis(2,2-dichloroacetamide)

N,N'-Octamethylenebis(dichloroacetamide),97%

N,N'-(Octane-1,8-diyl)bis(2,2-dichloroacetaMide)

AcetaMide,N,N'-1,8-octanediylbis[2,2-dichloro-

Fertilysine

SKL878

WIN 18446,Stra8,testis,spermatogenesis,inhibit,Win18446,Aldehyde Dehydrogenase (ALDH),Testes,Win-18446,Inhibitor

2,2-dichloro-N-[8-[(2,2-dichloroacetyl)amino]octyl]acetamide

N,N'-(Octane-1,8-diyl)bis(2,2-dichloroacetamide)

N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)

ACETAMIDE,N,N'-1,8-OCTANEDIYLBIS[2,2-DICHLORO-

1477-57-2

C12H20Cl4N2O2