4-amino-3,5-dimethyl-benzoic acid
- Product Name
- 4-amino-3,5-dimethyl-benzoic acid
- CAS No.
- 4919-40-8
- Chemical Name
- 4-amino-3,5-dimethyl-benzoic acid
- Synonyms
- NSC 38033;3,5-Dimethyl-4-aminobenzoic acid;4-amino-3,5-dimethyl-benzoic acid;Benzoic acid, 4-amino-3,5-dimethyl-
- CBNumber
- CB21465811
- Molecular Formula
- C9H11NO2
- Formula Weight
- 165.19
- MOL File
- 4919-40-8.mol
4-amino-3,5-dimethyl-benzoic acid Property
- Melting point:
- 251-252℃
- Boiling point:
- 342.5±30.0 °C(Predicted)
- Density
- 1.207
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 5.00±0.10(Predicted)
- Appearance
- Off-white to light brown Solid
N-Bromosuccinimide Price
- Product number
- A965895
- Product name
- 4-Amino-3,5-dimethylbenzoicacid
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J50399
- Product name
- 4-Amino-3,5-dimethylbenzoicacid
- Packaging
- 250mg
- Price
- $59
- Updated
- 2021/12/16
- Product number
- FA141921
- Product name
- 4-Amino-3,5-dimethylbenzoic acid
- Packaging
- 250mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FA141921
- Product name
- 4-Amino-3,5-dimethylbenzoic acid
- Packaging
- 500mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- J50399
- Product name
- 4-Amino-3,5-dimethylbenzoicacid
- Packaging
- 1g
- Price
- $148
- Updated
- 2021/12/16
4-amino-3,5-dimethyl-benzoic acid Chemical Properties,Usage,Production
Synthesis Reference(s)
Journal of the American Chemical Society, 70, p. 317, 1948 DOI: 10.1021/ja01181a097
Synthesis
3095-38-3
4919-40-8
3,5-Dimethyl-4-nitrobenzoic acid (976 mg, 5 mmol) was suspended in water (20 mL) under vigorous stirring for 30 min until the mixture was homogeneously dispersed. Sodium carbonate (Na2CO3, 300 mg, 2.8 mmol) and zinc powder (3 g, 30 mmol) were sequentially added to the suspension and the reaction mixture was subsequently heated to 30 °C. Concentrated hydrochloric acid (HCl, 10 mL) was added slowly and dropwise over a period of 20 min. After completion of the reaction, the mixture was filtered and the filter cake was washed twice with water (2 x 7 mL). To remove unreacted 3,5-dimethyl-4-nitrobenzoic acid, the filtrate was washed twice with ethyl acetate (2 × 40 mL). The pH of the aqueous layer was adjusted to 9.35 by adding saturated sodium carbonate solution (35 mL) and the precipitated zinc hydroxide (Zn(OH)2) was filtered. The filter cake was again washed twice with 5% sodium bicarbonate solution (2 x 10 mL). To remove the by-products, the filtrate was washed twice with ethyl acetate (2 × 80 mL). Subsequently, the pH of the aqueous layer was adjusted to 3.5 with 1N hydrochloric acid (~120 mL).Finally, the aqueous layer was extracted five times with ethyl acetate (5 × 80 mL). The organic layers were combined, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure. 4-Amino-3,5-dimethylbenzoic acid was obtained as a clear brown solid in 76% yield (629 mg).1H NMR (500 MHz, CD3CN): δ 8.94 (br s, 1H, OH), 7.55 (s, 2H, H3', H5'), 4.52 (br s, 2H, NH2), 2.15 (s, 6H, H7'). 13C NMR (126 MHz, CD3CN): δ 168.5 (C8'), 149.9 (C1'), 131.0 (C3', C5'), 122.4 (C4'), 121.4 (C2', C6'), 17.9 (C7'). MS (ESI+): m/z 166 [M + H]+.
References
[1] European Journal of Medicinal Chemistry, 2014, vol. 78, p. 236 - 247
[2] Justus Liebigs Annalen der Chemie, 1868, vol. 147, p. 50
[3] American Chemical Journal, 1910, vol. 44, p. 123
[4] American Chemical Journal, 1910, vol. 44, p. 508
[5] Biochemical Journal, 1950, vol. 46, p. 629,633
4-amino-3,5-dimethyl-benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-amino-3,5-dimethyl-benzoic acid Suppliers
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- Country
- India
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View Lastest Price from 4-amino-3,5-dimethyl-benzoic acid manufacturers
- Product
- 4-amino-3,5-dimethyl-benzoic acid 4919-40-8
- Price
- US $1.00-2.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20000KG
- Release date
- 2024-08-09