4-(Bromomethyl)-5-hydrofuran-2-one
- Product Name
- 4-(Bromomethyl)-5-hydrofuran-2-one
- CAS No.
- 61934-55-2
- Chemical Name
- 4-(Bromomethyl)-5-hydrofuran-2-one
- Synonyms
- 4-Bromomethyl-5H-furan-2-one;4-(BroMoMethyl)furan-2(5H)-one;4-(Bromomethyl)-2(5H)-furanone;3-(Bromomethyl)-2-buten-4-olide;2(5H)-Furanone, 4-(bromomethyl)-;4-(Bromomethyl)-5-hydrofuran-2-one;4-(Bromomethyl)-2,5-dihydrofuran-2-one;4-(Bromomethyl)-2,5-dihydrofuran-2-one - [B31582]
- CBNumber
- CB21483297
- Molecular Formula
- C5H5BrO2
- Formula Weight
- 177
- MOL File
- 61934-55-2.mol
4-(Bromomethyl)-5-hydrofuran-2-one Property
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- form
- liquid
- color
- Yellow
Safety
- HS Code
- 2932190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B697168
- Product name
- 4-(Bromomethyl)-5-hydrofuran-2-one
- Packaging
- 500mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- B31582
- Product name
- 4-(Bromomethyl)-2,5-dihydrofuran-2-one
- Purity
- 97%
- Packaging
- 5g
- Price
- $300
- Updated
- 2021/12/16
- Product number
- 2H25-9-63
- Product name
- 4-(Bromomethyl)furan-2(5H)-one
- Packaging
- 1g
- Price
- $303
- Updated
- 2021/12/16
- Product number
- 5995AJ
- Product name
- 4-(Bromomethyl)-5-hydrofuran-2-one
- Packaging
- 5g
- Price
- $551
- Updated
- 2021/12/16
- Product number
- 2H25-9-63
- Product name
- 4-(Bromomethyl)furan-2(5H)-one
- Packaging
- 5G
- Price
- $885
- Updated
- 2021/12/16
4-(Bromomethyl)-5-hydrofuran-2-one Chemical Properties,Usage,Production
Synthesis
75887-43-3
61934-55-2
Synthesis of 4-(bromomethyl)furan-2(5H)-one (8): 5% aqueous sodium hydroxide solution (100 mL) was stirred with compound 7 (1.98 g, 7.68 mmol) at room temperature overnight. After completion of the reaction, the reaction mixture was extracted with dichloromethane (3 x 150 mL), the organic phase was washed sequentially with saturated aqueous sodium bicarbonate solution and distilled water, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification by column chromatography (eluent ratio 4:1 hexane:ethyl acetate) afforded the target product 8 as a mixture of enol-keto interconverting isomers in the form of a yellow oil (150 mg, 11% yield). Thin layer chromatography (TLC) showed an Rf value of 0.00 (eluent ratio 4:1 hexane:ethyl acetate). The NMR hydrogen spectra (500 MHz, CDCl3) δH of the ketone interconversion isomers: 4.24 (2H, single peak, CH2Br), 4.98 (2H, single peak, CH2), 6.16 (1H, single peak, CH). NMR carbon spectrum (125.77 MHz, CDCl3) δC: 41.33 (CH2Br), 74.05 (CH2), 121.09 (CH), 155.42 (C), 178.32 (C=O). NMR hydrogen spectrum (500 MHz, CDCl3) δH of the enol intercalation isomers: 2.30 (1H, multiple peaks, CH2CH), 4.20 (2H, multiple peaks, CH2Br), 4.74 (2H, multiple peaks, CH2), 6.09 (1H, single peaks, CH), 9.10 (1H, broad single peaks, OH). Mass spectra (EI): m/z 149 [M-CO]- (100%), 96 (40), 68 (50), 39 (70). Gas Chromatography (GC) retention time: 6.57 min.
References
[1] Journal of Mass Spectrometry, 2009, vol. 44, # 12, p. 1733 - 1741
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 3074 - 3077
[3] Tetrahedron, 1996, vol. 52, # 37, p. 12137 - 12158
[4] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 4, p. 1626 - 1632
[5] European Journal of Organic Chemistry, 2014, vol. 2014, # 19, p. 4053 - 4069
4-(Bromomethyl)-5-hydrofuran-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(Bromomethyl)-5-hydrofuran-2-one manufacturers
- Product
- 4-(Bromomethyl)-5-hydrofuran-2-one 61934-55-2
- Price
- US $0.01/KG
- Min. Order
- 500g
- Purity
- 98%; 99%
- Supply Ability
- 500g；1kg； 10kg; 25kg
- Release date
- 2020-01-08