Minaprine dihydrochloride

Product Name: Minaprine dihydrochloride
CAS No.: 25953-17-7
Chemical Name: Minaprine dihydrochloride
Synonyms: Ag 620;Agr 620;Agr 1240;Nsc305742;Minaprine dihydrochloride, 10 mM in DMSO;4-Methyl-N-(2-morpholinoethyl)-6-phenylpyridazin-3-amine dihydrochloride;Monoamine Oxidase,MAO,Minaprine dihydrochloride,inhibit,Inhibitor,Minaprine;Pyridazine, 4-methyl-3-[(2-morpholinoethyl)amino]-6-phenyl-, dihydrochloride;4-Morpholineethanamine, N-(4-methyl-6-phenyl-3-pyridazinyl)-, dihydrochloride;Morpholine, 4-[2-[(4-methyl-6-phenyl-3-pyridazinyl)amino]ethyl]-, dihydrochloride
CBNumber: CB21485680
Molecular Formula: C17H24Cl2N4O
Formula Weight: 371.30466
MOL File: 25953-17-7.mol

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Minaprine dihydrochloride Property

Melting point:: 182°
storage temp.: Store at -20°C
solubility: DMSO : ≥ 100 mg/mL (269.32 mM)
form: Solid
color: White to off-white

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Safety

Toxicity: LD50 intraperitoneal in mouse: 63mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-4347
Product name: Minaprine dihydrochloride
Purity: 99.61%
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FM158555
Product name: Minaprine dihydrochloride
Packaging: 500mg
Price: $80
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FM158555
Product name: Minaprine dihydrochloride
Packaging: 1g
Price: $125
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FM158555
Product name: Minaprine dihydrochloride
Packaging: 2g
Price: $200
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003396
Product name: MINAPRINE DIHYDROCHLORIDE
Purity: 95.00%
Packaging: 10MG
Price: $280.35
Updated: 2021/12/16

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Minaprine dihydrochloride Chemical Properties,Usage,Production

Originator

Cantor,Clin Midy,France,1979

Uses

Antidepressant.

Manufacturing Process

(a) Preparation of the free base: A mixture comprising 0.1 mol (20.4 g) of 3-chloro-4-methyl-6-phenylpyridazine and 0.2 mol (26.2 g) of N-(2-aminoethyl)-morpholine in 100 ml of n-butanol, with a pinch of copper powder, was heatedunder reflux for 12 hours. At the end of this time, the hot solution was pouredinto 200 ml of cold water. The resulting mixture was filtered through asintered glass filter and the precipitate washed with ether. The filtrate and theether washings were placed in a separating funnel and extracted with two 150ml portions of ether. The ethereal layer was then extracted with about 250 mlof N sulfuric acid.
The acid solution was made alkaline with a 10% aqueous solution of sodiumcarbonate, and left to crystallize overnight.
The solution was filtered, yielding the colorless needles which wererecrystallized from isopropanol. The yield was 15 g (53%).
(b) Preparation of the hydrochloride: The base was dissolved in the smallestamount possible of anhydrous acetone. Double that volume of anhydrousether was added, and a stream of hydrogen chloride gas was passed throughthe solution. The hydrochloride salt obtained was recrystallized from absolutealcohol. The yield after recrystallization was 17 g (90%).

Therapeutic Function

Antidepressant

Minaprine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Minaprine dihydrochloride Suppliers

China 16 United Kingdom 1 United States 7 Global 24

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185;
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32469
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Shanghai Luofa Biochemical Technology Co., Ltd.

Tel: 021-51111890 15317326293
Email: sales@molnova.com
Country: China
ProdList: 4195
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11972
Advantage: 58

25953-17-7, Minaprine dihydrochlorideRelated Search:

4-Morpholineethanamine, N-(4-methyl-6-phenyl-3-pyridazinyl)-, dihydrochloride

Ag 620

Agr 1240

Agr 620

Morpholine, 4-[2-[(4-methyl-6-phenyl-3-pyridazinyl)amino]ethyl]-, dihydrochloride

Nsc305742

Pyridazine, 4-methyl-3-[(2-morpholinoethyl)amino]-6-phenyl-, dihydrochloride

4-Methyl-N-(2-morpholinoethyl)-6-phenylpyridazin-3-amine dihydrochloride

Monoamine Oxidase,MAO,Minaprine dihydrochloride,inhibit,Inhibitor,Minaprine

Minaprine dihydrochloride, 10 mM in DMSO

25953-17-7

C17H24Cl2N4O