6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE

Product Name: 6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE
CAS No.: 59611-52-8
Chemical Name: 6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE
Synonyms: 6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE;Quinoline, 6-fluoro-1,2,3,4-tetrahydro-;6-Fluoro-1,2,3,4-tetrahydroquinoline,97%
CBNumber: CB21495087
Molecular Formula: C9H10FN
Formula Weight: 151.18
MOL File: 59611-52-8.mol

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6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE Property

Melting point:: 32-34℃
Boiling point:: 248.0±29.0 °C(Predicted)
Density: 1.107±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 5.15±0.20(Predicted)
Appearance: Off-white to light brown <32°C Solid,>34°C Liquid
CAS DataBase Reference: 59611-52-8

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B440065
Product name: 6-fluoro-1,2,3,4-tetrahydroquinoline
Packaging: 100mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: 8873AB
Product name: 6-Fluoro-1,2,3,4-tetrahydroquinoline
Packaging: 250mg
Price: $81
Updated: 2021/12/16

ChemScene

Product number: CS-W007199
Product name: 6-Fluoro-1,2,3,4-tetrahydroquinoline
Purity: 99.79%
Packaging: 250mg
Price: $46
Updated: 2021/12/16

Ark Pharm

Product number: P000378886
Product name: 6-Fluoro-1,2,3,4-tetrahydroquinoline
Purity: 97%
Packaging: 250mg
Price: $59
Updated: 2021/12/16

Apolloscientific

Product number: PC52113
Product name: 6-Fluoro-1,2,3,4-tetrahydroquinoline
Packaging: 1g
Price: $280
Updated: 2021/12/16

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6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE Chemical Properties,Usage,Production

Uses

6-Fluoro-1,2,3,4-tetrahydroquinoline is used as pharmaceutical intermediate.

Synthesis

75893-82-2

59611-52-8

A THF solution of 6-fluoro-3,4-dihydroquinolin-2(1H)-one (6.0 g, 36.36 mmol) was slowly added to a THF (80 mL) suspension of LiAlH4 (2.76 g, 72.73 mmol) under stirring conditions. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction was quenched with saturated sodium chloride solution and ethyl acetate and filtered through diatomaceous earth. The filtrate was diluted with ethyl acetate and washed sequentially with water and saturated sodium chloride solution and the organic phase was dried with anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give 4.5 g (81% yield) of 6-fluoro-1,2,3,4-tetrahydroquinoline as a brown liquid.1H NMR (400 MHz, CDCl3): δ 6.65-6.78 (m, 2H), 6.37-6.40 (m, 1H), 3.26 (t, J=5.3 Hz, 2H), 2.73 (t, J=6.6 Hz, 2H), 1.88-1.94 (m, 2H).

References

[1] Patent: WO2017/142883, 2017, A1. Location in patent: Paragraph 0183; 0186
[2] Patent: WO2014/78813, 2014, A1. Location in patent: Page/Page column 141

6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE Suppliers

China 69 India 2 Ukraine 1 United Kingdom 1 United States 9 Global 82

PharmaBlock Sciences (Nanjing),Inc.

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Bide Pharmatech Ltd.

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Mashilabs (Shanghai) Co.,Ltd.

Tel: 19916721580
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View Lastest Price from 6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE manufacturers

Career Henan Chemical Co

Product: 6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE 59611-52-8
Price: US $5.50/KG
Min. Order: 1KG
Purity: 98%-99%
Supply Ability: 1kg-100kg
Release date: 2020-01-07

59611-52-8, 6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINERelated Search:

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6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE

Quinoline, 6-fluoro-1,2,3,4-tetrahydro-

6-Fluoro-1,2,3,4-tetrahydroquinoline,97%

59611-52-8