6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE
- Product Name
- 6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE
- CAS No.
- 59611-52-8
- Chemical Name
- 6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE
- Synonyms
- 6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE;Quinoline, 6-fluoro-1,2,3,4-tetrahydro-;6-Fluoro-1,2,3,4-tetrahydroquinoline,97%
- CBNumber
- CB21495087
- Molecular Formula
- C9H10FN
- Formula Weight
- 151.18
- MOL File
- 59611-52-8.mol
6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE Property
- Melting point:
- 32-34℃
- Boiling point:
- 248.0±29.0 °C(Predicted)
- Density
- 1.107±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 5.15±0.20(Predicted)
- Appearance
- Off-white to light brown <32°C Solid,>34°C Liquid
- CAS DataBase Reference
- 59611-52-8
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B440065
- Product name
- 6-fluoro-1,2,3,4-tetrahydroquinoline
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 8873AB
- Product name
- 6-Fluoro-1,2,3,4-tetrahydroquinoline
- Packaging
- 250mg
- Price
- $81
- Updated
- 2021/12/16
- Product number
- CS-W007199
- Product name
- 6-Fluoro-1,2,3,4-tetrahydroquinoline
- Purity
- 99.79%
- Packaging
- 250mg
- Price
- $46
- Updated
- 2021/12/16
- Product number
- P000378886
- Product name
- 6-Fluoro-1,2,3,4-tetrahydroquinoline
- Purity
- 97%
- Packaging
- 250mg
- Price
- $59
- Updated
- 2021/12/16
- Product number
- PC52113
- Product name
- 6-Fluoro-1,2,3,4-tetrahydroquinoline
- Packaging
- 1g
- Price
- $280
- Updated
- 2021/12/16
6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE Chemical Properties,Usage,Production
Uses
6-Fluoro-1,2,3,4-tetrahydroquinoline is used as pharmaceutical intermediate.
Synthesis
75893-82-2
59611-52-8
A THF solution of 6-fluoro-3,4-dihydroquinolin-2(1H)-one (6.0 g, 36.36 mmol) was slowly added to a THF (80 mL) suspension of LiAlH4 (2.76 g, 72.73 mmol) under stirring conditions. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction was quenched with saturated sodium chloride solution and ethyl acetate and filtered through diatomaceous earth. The filtrate was diluted with ethyl acetate and washed sequentially with water and saturated sodium chloride solution and the organic phase was dried with anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give 4.5 g (81% yield) of 6-fluoro-1,2,3,4-tetrahydroquinoline as a brown liquid.1H NMR (400 MHz, CDCl3): δ 6.65-6.78 (m, 2H), 6.37-6.40 (m, 1H), 3.26 (t, J=5.3 Hz, 2H), 2.73 (t, J=6.6 Hz, 2H), 1.88-1.94 (m, 2H).
References
[1] Patent: WO2017/142883, 2017, A1. Location in patent: Paragraph 0183; 0186
[2] Patent: WO2014/78813, 2014, A1. Location in patent: Page/Page column 141
6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE Suppliers
- Tel
- --
- Fax
- --
- sales@apolloscientific.co.uk
- Country
- United Kingdom
- ProdList
- 6084
- Advantage
- 88
View Lastest Price from 6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE manufacturers
- Product
- 6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE 59611-52-8
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%-99%
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-07