ChemicalBook > CAS DataBase List > 4,4'-DIACETAMIDODIPHENYLMETHANE

4,4'-DIACETAMIDODIPHENYLMETHANE

Product Name
4,4'-DIACETAMIDODIPHENYLMETHANE
CAS No.
2719-05-3
Chemical Name
4,4'-DIACETAMIDODIPHENYLMETHANE
Synonyms
BRD-K4477;NSC 12407;FH1(BRD-K4477);N,N'-AcetylMDA;FH1 (NSC 12407;FH1 >=98% (HPLC);FH1, 10 mM in DMSO;4,4'-diacetamidodiphenylmethane;4',4'-METHYLENEBIS(ACETANILIDE);4',4'-METHYLENEBIS(ACETANILIDE)
CBNumber
CB2149684
Molecular Formula
C17H18N2O2
Formula Weight
282.34
MOL File
2719-05-3.mol
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4,4'-DIACETAMIDODIPHENYLMETHANE Property

Melting point:
227-228 °C
Boiling point:
564.6±43.0 °C(Predicted)
Density 
1.201±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
Soluble in DMSO (up to 30 mg/ml)
form 
solid
pka
14.73±0.70(Predicted)
color 
White
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

Hazard Codes 
N
Risk Statements 
50/53
Safety Statements 
60-61
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0826
Product name
FH1
Purity
≥98% (HPLC)
Packaging
5MG
Price
$77.7
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0826
Product name
FH1
Purity
≥98% (HPLC)
Packaging
25MG
Price
$308
Updated
2025/07/31
Sigma-Aldrich
Product number
S685682
Product name
4',4''-METHYLENEBIS(ACETANILIDE)
Purity
Aldrich<sup>CPR</sup>
Packaging
1 unit
Price
$42.8
Updated
2025/07/31
Sigma-Aldrich
Product number
S685682
Product name
4'',4''''-METHYLENEBIS(ACETANILIDE)
Purity
AldrichCPR
Packaging
250MG
Price
$41.5
Updated
2024/03/01
Cayman Chemical
Product number
18415
Product name
BRD-K4477
Purity
≥98%
Packaging
5mg
Price
$49
Updated
2024/03/01
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4,4'-DIACETAMIDODIPHENYLMETHANE Chemical Properties,Usage,Production

Description

FH-1 (2719-05-3) enhances differentiation of induced pluripotent stem cells (iPSC) to hepatocytes. Promotes the maturation of iPSC-derived hepatocytes.

Uses

FH 1 is used as an inducer of cell proliferations (i.e. inducing proliferation and differentiation of stem cells for formation of hepatocytes for treatment of liver disease).

Synthesis

108-24-7

101-77-9

2719-05-3

To a solution of 4,4'-diaminodiphenylmethane (50 mg, 0.25 mmol), pyridine (47 mg, 0.60 mmol) and 4-(dimethylamino)pyridine (1 mg) in dichloromethane (2.5 mL) was added acetic anhydride (56 mg, 0.55 mmol). The reaction mixture was stirred at 0 °C and gradually warmed to 25 °C for 12 hours. Upon completion of the reaction, the mixture was poured into water (10 mL) and extracted with ethyl acetate (50 mL x 2). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. To the residue was added ether (10 mL) and the resulting precipitate was collected by filtration to give N,N'-diacetamidodiphenylmethane (59 mg, 0.21 mmol, 84% yield) as a colorless solid. Melting point: 224-225°C (decomposition).1H NMR (DMSO-d6): δ2.02 (s, 6H), 3.80 (s, 2H), 7.11 (d, J=8.2Hz, 4H), 7.48 (d, J=8.2Hz, 4H), 9.88 (br, 2H).13C NMR (DMSO-d6): δ24.2,40.2 ,119.3,129.0,136.3,137.5,168.3. IR (ATR): 1650 cm-1. MS (EI): m/z 282 (M+). Elemental analysis (C17H18N2O2) Calculated values: C, 72.32; H, 6.43; N, 9.92. Measured values: C, 72.21; H, 6.42; N, 9.91.

storage

+4°C

References

[1] JING SHAN. Identification of small molecules for human hepatocyte expansion and iPS differentiation[J]. Nature chemical biology, 2013, 9 8: 514-520. DOI:10.1038/nchembio.1270

4,4'-DIACETAMIDODIPHENYLMETHANE Preparation Products And Raw materials

Raw materials

Preparation Products

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4,4'-DIACETAMIDODIPHENYLMETHANE Suppliers

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2719-05-3, 4,4'-DIACETAMIDODIPHENYLMETHANERelated Search:

4,4'-DIACETAMIDODIPHENYLMETHANE 4,4',4''-TRIS(4,5-DICHLOROPHTHALIMIDO)TRITYL BROMIDE Diphenylmethane Bismaleimide BIS(3-ETHYL-5-METHYL-4-MALEIMIDOPHENYL)METHANE N-(4-(9-[4-(3-CARBOXY-PROPIONYLAMINO)-PHENYL]-9H-FLUOREN-9-YL)-PHENYL)-SUCCINAMIC ACID BIO-FARMA BF003995 N-(4-[4-(3-CARBOXY-PROPIONYLAMINO)-BENZYL]-PHENYL)-SUCCINAMIC ACID RHODAMINE 110, BIS-(N-CBZ-L-ALANYL-L-ALANYL-L- ASPARTIC ACID AMIDE) N,N'-(methylenedi-p-phenylene)bis[3,4,5,6,-tetrabromophthalimide] 2-(1-PYRROLIDINYL)-N-[4-(4-([2-(1-PYRROLIDINYL)ACETYL]AMINO)BENZYL)PHENYL]ACETAMIDE 2-PIPERIDINO-N-(4-(4-[(2-PIPERIDINOACETYL)AMINO]BENZYL)PHENYL)ACETAMIDE 2-MORPHOLINO-N-(4-(4-[(2-MORPHOLINOACETYL)AMINO]BENZYL)PHENYL)ACETAMIDE N,N'-(4,4'-METHYLENEBIS(2-METHOXY-4,1-PHENYLENE))DITHIOPHENE-2-CARBOXAMIDE RHODAMINE 110, BIS-(N-CBZ-L-LEUCYL-L-GLUTAMYL-L- GLUTAMYL-L-ASPARTIC ACID AMIDE) RHODAMINE 110, BIS-(N-CBZ-L-LEUCYL-L-GLUTAMYL-L- HISTIDINYL-L-ASPARTIC ACID AMIDE) VITAS-BB TBB000597 RHODAMINE 110, BIS-(N-CBZ-L-VALYL-L-GLUTAMYL-L- ISOLEUCYL-L-ASPARTIC ACID AMIDE)

  • N-[4-(4-acetamidobenzyl)phenyl]acetamide
  • N-[4-[(4-acetamidophenyl)methyl]phenyl]acetamide
  • N-[4-[(4-acetamidophenyl)methyl]phenyl]ethanamide
  • N,N'-(4,4'-Methylenebis(4,1-phenylene))diacetaMide
  • FH1(BRD-K4477)
  • Acetamide,N,N'-(methylenedi-4,1-phenylene)bis-
  • BRD-K4477
  • N,N′-(Methylenedi-4,1-phenylene)bis-acetamide
  • N,N′-(Methylenedi-4,1-phenylene)diacetamide
  • NSC 12407
  • N,N-Acetyl MDA~Bis(4-acetamidophenyl)methane~4,4-Methylenedibenzamide
  • Bis(4-acetamidophenyl)methane~4,4'-Methylenedibenzamide
  • N,N'-AcetylMDA
  • 4,4''-DIACETAMIDODIPHENYLMETHANE 98%
  • NSC 12407; BRD-K4477; FH 1; NSC12407; BRDK4477
  • FH1 >=98% (HPLC)
  • N,N'-(Methylenebis(4,1-phenylene))diacetamide
  • hHNF4α,IPS,hALB,iPSC,FH1,FH-1,inhibit,Inhibitor,hNTCP,NSC12407,NSC-12407,hRXR,FH 1
  • 4,4'-diacetamidodiphenylmethane
  • FH1, 10 mM in DMSO
  • 4',4'-METHYLENEBIS(ACETANILIDE)
  • 4',4'-METHYLENEBIS(ACETANILIDE)
  • FH1 (NSC 12407
  • 4,4'-diacetamidodiphenylmethane
  • 2719-05-3
  • Inhibitors