2,5,6-TRICHLORO-1H-BENZIMIDAZOLE
- Product Name
- 2,5,6-TRICHLORO-1H-BENZIMIDAZOLE
- CAS No.
- 16865-11-5
- Chemical Name
- 2,5,6-TRICHLORO-1H-BENZIMIDAZOLE
- Synonyms
- MaribavirIntermediate;2,5,6-Trichlorobenzimidazole;Benzimidazole, 2,5,6-trichloro-;2,5,6-TRICHLORO-1H-BENZIMIDAZOLE;2,5,6-trichloro-3aH-benzimidazole;1H-Benzimidazole, 2,5,6-trichloro-;2,5,6-trichloro-1H-1,3-benzodiazole;2,5,6-trichloro-1H-benzo[d]imidazole
- CBNumber
- CB21502301
- Molecular Formula
- C7H3Cl3N2
- Formula Weight
- 221.47
- MOL File
- 16865-11-5.mol
2,5,6-TRICHLORO-1H-BENZIMIDAZOLE Property
- Boiling point:
- 399.3±45.0 °C(Predicted)
- Density
- 1.691±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 6.87±0.10(Predicted)
- Appearance
- Off-white to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 8612AA
- Product name
- 2,5,6-Trichloro-1H-benzo[d]imidazole
- Packaging
- 250mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- HCH0036652
- Product name
- 2,5,6-TRICHLOROBENZIMIDAZOLE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $246.75
- Updated
- 2021/12/16
- Product number
- 084015
- Product name
- 2,5,6-Trichloro-1H-benzimidazole
- Purity
- 95%
- Packaging
- 1g
- Price
- $524
- Updated
- 2021/12/16
- Product number
- 8612AA
- Product name
- 2,5,6-Trichloro-1H-benzo[d]imidazole
- Packaging
- 5g
- Price
- $847
- Updated
- 2021/12/16
- Product number
- 49033
- Product name
- 2,5,6-Trichlorobenzimidazole
- Packaging
- 50mg
- Price
- $625
- Updated
- 2021/12/16
2,5,6-TRICHLORO-1H-BENZIMIDAZOLE Chemical Properties,Usage,Production
Uses
2,5,6-Trichlorobenzimidazole has been used in the synthesis of trihaloribofuranosylbenzimidazole derivatives with antiviral activity.
Synthesis
2033-29-6
16865-11-5
The general procedure for the synthesis of 2,5,6-trichlorobenzimidazole using 5,6-dichloro-1H-benzo[d]imidazol-2(3H)-one as starting material was as follows: completely dry 5,6-dichloro-1,3-dihydro-benzimidazol-2-one (28.4 g, 0.14 mol) was suspended in trichlorophosphorus (POCl3, 75 mL). The reaction mixture was heated to reflux temperature, kept for 3 h and then cooled to room temperature. The reaction solution was slowly poured into crushed ice/water mixture (1.5 L) under vigorous stirring. The pH of the mixture was adjusted with sodium hydroxide (NaOH) solution to 7.0. The precipitated solid product was collected by filtration, washed with water and dried to afford 2,5,6-trichlorobenzimidazole (27.9 g, 90% yield). The crude product obtained can be used directly in the subsequent reaction without further purification.
References
[1] Patent: WO2009/134750, 2009, A1. Location in patent: Page/Page column 60
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 15, p. 7188 - 7211
[3] Patent: WO2011/23812, 2011, A1. Location in patent: Page/Page column 69
[4] Patent: WO2012/117062, 2012, A1. Location in patent: Page/Page column 29
[5] Journal of Medicinal Chemistry, 1997, vol. 40, # 4, p. 586 - 593
2,5,6-TRICHLORO-1H-BENZIMIDAZOLE Preparation Products And Raw materials
Raw materials
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