ChemicalBook > CAS DataBase List > (S)-3-PIPERIDINE-3-CARBOXYLIC ACID

(S)-3-PIPERIDINE-3-CARBOXYLIC ACID

Product Name
(S)-3-PIPERIDINE-3-CARBOXYLIC ACID
CAS No.
851956-01-9
Chemical Name
(S)-3-PIPERIDINE-3-CARBOXYLIC ACID
Synonyms
L(+)-NIPECOTIC ACID HCL;(S)-(+)-Nipecotic acid HCl;L(+)-nipecotic acid hydrochloride;(S)-3-PIPERIDINE-3-CARBOXYLIC ACID;(3S)-3-Piperidinecarboxylic acid hydrochloride;(3S)-piperidine-3-carboxylic acid hydrochloride;(S)-3-Piperidine-3-CarboxylicAcid hydrochloride;(3S)-3-Piperidinecarboxylic acid hydrochloride salt
CBNumber
CB21502811
Molecular Formula
C6H12ClNO2
Formula Weight
165.62
MOL File
851956-01-9.mol
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(S)-3-PIPERIDINE-3-CARBOXYLIC ACID Property

storage temp. 
Inert atmosphere,Room Temperature
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ark Pharm
Product number
P000106143
Product name
(S)-Piperidine-3-carboxylic acid hydrochloride
Purity
98%
Packaging
250mg
Price
$7
Updated
2021/12/16
Ark Pharm
Product number
P000106143
Product name
(S)-Piperidine-3-carboxylic acid hydrochloride
Purity
98%
Packaging
1g
Price
$15
Updated
2021/12/16
Activate Scientific
Product number
AS48700
Product name
(S)-Piperidine-3-carboxylic acid hydrochloride
Purity
98% ee
Packaging
1g
Price
$40
Updated
2021/12/16
Ark Pharm
Product number
P000106143
Product name
(S)-Piperidine-3-carboxylic acid hydrochloride
Purity
98%
Packaging
5g
Price
$59
Updated
2021/12/16
Ark Pharm
Product number
P000106143
Product name
(S)-Piperidine-3-carboxylic acid hydrochloride
Purity
98%
Packaging
10g
Price
$106
Updated
2021/12/16
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(S)-3-PIPERIDINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

88495-54-9

851956-01-9

The general steps for the synthesis of (S)-piperidine-3-carboxylic acid hydrochloride from N-Boc-(S)-3-carboxylic acid piperidine are as follows: Step 1. Preparation of (3S)-piperidine-3-carboxylic acid hydrochloride (3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (4.0 g, 0.017 mol) was dissolved in dichloromethane (10 mL, 0.2 mol), and a 1,4-dioxane solution (30 mL) of 4.0 M hydrogen chloride was added. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the volatiles were removed by vacuum distillation to give (3S)-piperidine-3-carboxylic acid hydrochloride in quantitative yield. The crude product did not require further purification and could be used directly in subsequent steps.LCMS analysis showed m/z 166.2 (M + H)+.

References

[1] Patent: US2006/4049, 2006, A1. Location in patent: Page/Page column 49
[2] Patent: WO2012/131379, 2012, A1. Location in patent: Page/Page column 25
[3] Patent: US2014/206703, 2014, A1. Location in patent: Paragraph 0106; 0107

(S)-3-PIPERIDINE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-3-PIPERIDINE-3-CARBOXYLIC ACID Suppliers

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