3-NITRO-5-PHENYLACETYL CATECHOL

Product Name: 3-NITRO-5-PHENYLACETYL CATECHOL
CAS No.: 274925-86-9
Chemical Name: 3-NITRO-5-PHENYLACETYL CATECHOL
Synonyms: Bia 3-202;Nebicapone;3-NITRO-5-PHENYLACETYL CATECHOL;Ethanone, 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenyl-
CBNumber: CB21506152
Molecular Formula: C14H11NO5
Formula Weight: 273.24
MOL File: 274925-86-9.mol

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3-NITRO-5-PHENYLACETYL CATECHOL Property

Melting point:: 178–179°C
Boiling point:: 454.2±45.0 °C(Predicted)
Density: 1.435±0.06 g/cm3(Predicted)
pka: 5.01±0.38(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: KIN0001301
Product name: BIA-3-202
Purity: 95.00%
Packaging: 10G
Price: $774.9
Updated: 2021/12/16

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3-NITRO-5-PHENYLACETYL CATECHOL Chemical Properties,Usage,Production

Uses

Nebicapone (BIA 3-202), a reversible catechol-O-methyltransferase (COMT) inhibitor, is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of COMT, and it is potential for the treatment of Parkinson's disease[1].

Preparation

Preparation by treatment of 1-(4-hydroxy-3- methoxy-5-nitrophenyl)-2-phenylethanone with aluminium chloride in refluxing ethyl acetate/ pyridine mixture for 2 h (99%).

References

[1] Loureiro AI, et al. Human metabolism of nebicapone (BIA 3-202), a novel catechol-o-methyltransferase inhibitor: characterization of in vitro glucuronidation. Drug Metab Dispos. 2006 Nov;34(11):1856-62. DOI:10.1124/dmd.106.010447

3-NITRO-5-PHENYLACETYL CATECHOL Preparation Products And Raw materials

Raw materials

Preparation Products

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3-NITRO-5-PHENYLACETYL CATECHOL Suppliers

China 11 Germany 1 India 1 United Kingdom 1 United States 5 Global 19

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274925-86-9, 3-NITRO-5-PHENYLACETYL CATECHOLRelated Search:

3'-NITRO-2-PHENYLACETOPHENONE 3-NITRO-5-PHENYLACETYL CATECHOL

3-NITRO-5-PHENYLACETYL CATECHOL

Nebicapone

Bia 3-202

Ethanone, 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenyl-

274925-86-9