FERROQUINE
- Product Name
- FERROQUINE
- CAS No.
- 185055-67-8
- Chemical Name
- FERROQUINE
- Synonyms
- SSR 97193;FERROQUINE;Ferrochloroquine;Ferroquine, 10 mM in DMSO;7-Chloro-4-(((2-((dimethylamino)methyl)ferrocenyl)methyl)amino)quinoline;1-[[(7-Chloro-4-quinolinyl)amino]methyl]-2-[(dimethylamino)methyl]ferrocene
- CBNumber
- CB21509113
- Molecular Formula
- C18H19ClN3.C5H5.Fe
- Formula Weight
- 433.762
- MOL File
- 185055-67-8.mol
FERROQUINE Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : 8.33 mg/mL (19.20 mM)
- form
- Solid
- color
- Light yellow to orange
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P314Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML2350
- Product name
- Ferroquine
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $78.4
- Updated
- 2025/07/31
- Product number
- SML2350
- Product name
- Ferroquine
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $449
- Updated
- 2025/07/31
- Product number
- F307600
- Product name
- Ferroquine
- Packaging
- 25mg
- Price
- $485
- Updated
- 2021/12/16
- Product number
- API0019313
- Product name
- FERROQUINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.48
- Updated
- 2021/12/16
- Product number
- CS-7610
- Product name
- Ferroquine
- Purity
- 99.68%
- Packaging
- 50mg
- Price
- $510
- Updated
- 2021/12/16
FERROQUINE Chemical Properties,Usage,Production
Uses
Ferroquine is a ferrocene-based analogue of the antimalarial drug chloroquine.
Biological Activity
Ferroquine (SSR 97193) is an antimalarial chloroquine analog effective against chloroquine-resistant Plasmodium falciparum. Ferroquine is thought to act by producing oxidative stress and by inhibiting the formation of hemozoin, produced by Malaria parasites as a disposal product of heme, which would otherwise be toxic to the Plasmodium cells.
in vivo
Treatment of mice with 200 and 800?mg/kg Ferroquine, shows low total worm burden reductions of 19.4% and 35.6%. One of the mice treated with 800?mg/kg Ferroquine died within 24?hours post-treatment. No activity is observed treating mice with RQ at 200?mg/kg. Finally, a total worm burden reduction of 17.3% is observed following treatment with FQ-OH. Hence, modification of Chloroquine (CQ) by a ferrocenyl or ruthenocenyl fragment does not increase the antischistosomal properties of CQ. For comparison, at 200?mg/kg mefloquine (MQ) achieves a much higher worm burden reduction of 72.3% in S. mansoni-infected mice. A higher effect against female adult S. mansoni is also observed in MQ treated mice pointing to a sex-specific interference of these drugs with the target. Furthermore, in one of the FQ-OH treated mice many dead worms are recovered and a hepatic shift (i.e. worms migrating to the liver) observed. Hence, Ferroquine and FQ-OH show weak antischistosomal activity in vivo[1].
IC 50
Plasmodium
FERROQUINE Preparation Products And Raw materials
Raw materials
Preparation Products
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