ISOVALERYL-L-CARNITINE CHLORIDE

Product Name: ISOVALERYL-L-CARNITINE CHLORIDE
CAS No.: 139144-12-0
Chemical Name: ISOVALERYL-L-CARNITINE CHLORIDE
Synonyms: Isovalerylcarnitine chloride;ISOVALERYL-L-CARNITINE CHLORIDE;Isovaleryl-L-carnitine HCl in Water;L-CARNITINE:HCL, O-ISOVALERYL UNLABELED;Isovaleryl-L-carnitine-d3 HCl (N-methyl-d3);1-Propanaminium,3-carboxy-N,N,N-trimethyl-2-(3-methyl-1-oxobutoxy)-, chloride, (2R)-
CBNumber: CB21511110
Molecular Formula: C12H22ClNO3
Formula Weight: 263.76098
MOL File: 139144-12-0.mol

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ISOVALERYL-L-CARNITINE CHLORIDE Property

Melting point:: >160°C (dec.)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: Methanol (Slightly), Water (Slightly, Heated)
form: Solid
color: White to Off-White
Stability:: Hygroscopic
CAS Number Unlabeled: 139144-12-0

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26555
Product name: Isovaleryl-L-carnitine (chloride)
Packaging: 25mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 26555
Product name: Isovaleryl-L-carnitine (chloride)
Packaging: 100mg
Price: $346
Updated: 2024/03/01

Cayman Chemical

Product number: 26555
Product name: Isovaleryl-L-carnitine (chloride)
Packaging: 50mg
Price: $184
Updated: 2024/03/01

TRC

Product number: I917580
Product name: IsovalerylL-CarnitineChloride
Packaging: 100mg
Price: $185
Updated: 2021/12/16

TRC

Product number: I917580
Product name: IsovalerylL-CarnitineChloride
Packaging: 1g
Price: $1355
Updated: 2021/12/16

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ISOVALERYL-L-CARNITINE CHLORIDE Chemical Properties,Usage,Production

Description

Isovaleryl-L-carnitine is a naturally occurring acylcarnitine that is formed via metabolic conversion of L-leucine. It increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes when used at a concentration of 1 mM. Isovaleryl-L-carnitine inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver when used at concentrations of 77 and 100 μM, respectively. Increased levels of isovaleryl carnitine are associated with isovaleryl-CoA dehydrogenase deficiency (isovaleric acidemia).

Uses

Isovaleryl L-Carnitine Chloride is used to prepare carnitine benzyl esters as neuroprotectant prodrugs.

IC 50

Human Endogenous Metabolite

References

[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] ROBERTO PAOLO REVOLTELLA . l-Carnitine and some of its analogs delay the onset of apoptotic cell death initiated in murine C2.8 hepatocytic cells after hepatocyte growth factor deprivation[J]. Biochimica et biophysica acta. Molecular cell research, 1994, 1224 3: Pages 333-341. DOI: 10.1016/0167-4889(94)90265-8
[3] G MIOTTO. Control of hepatic proteolysis by leucine and isovaleryl-L-carnitine through a common locus. Evidence for a possible mechanism of recognition at the plasma membrane.[J]. The Journal of Biological Chemistry, 1992, 267 31: 22066-22072.
[4] PIERO RINALDO Dietrich M Tina M Cowan. Acylcarnitine profile analysis[J]. Genetics in Medicine, 2008, 10 2: Pages 151-156. DOI: 10.1097/gim.0b013e3181614289

ISOVALERYL-L-CARNITINE CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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139144-12-0, ISOVALERYL-L-CARNITINE CHLORIDERelated Search:

ISOVALERYL-L-CARNITINE CHLORIDE

L-CARNITINE:HCL, O-ISOVALERYL UNLABELED

Isovaleryl-L-carnitine-d3 HCl (N-methyl-d3)

1-Propanaminium,3-carboxy-N,N,N-trimethyl-2-(3-methyl-1-oxobutoxy)-, chloride, (2R)-

Isovalerylcarnitine chloride

Isovaleryl-L-carnitine HCl in Water

139144-12-0