5-CYANOFURAN-2-CARBOXYLICACID
- Product Name
- 5-CYANOFURAN-2-CARBOXYLICACID
- CAS No.
- 212197-74-5
- Chemical Name
- 5-CYANOFURAN-2-CARBOXYLICACID
- Synonyms
- 184747;5-CYANOFURAN-2-CARBOXYLICACID;2-Cyano-5-furancarboxylic acid;5-cyano-2-furancarboxylic acid;2-Furancarboxylic acid, 5-cyano-
- CBNumber
- CB21511620
- Molecular Formula
- C6H3NO3
- Formula Weight
- 137.09
- MOL File
- 212197-74-5.mol
5-CYANOFURAN-2-CARBOXYLICACID Property
- Boiling point:
- 314℃
- Density
- 1.47
- Flash point:
- 144℃
- storage temp.
- 2-8°C
- pka
- 2.23±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C991263
- Product name
- 5-Cyanofuran-2-carboxylicacid
- Packaging
- 100mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- CHM0390669
- Product name
- 5-CYANOFURAN-2-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.27
- Updated
- 2021/12/16
- Product number
- 097839
- Product name
- 5-Cyanofuran-2-carboxylic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $643
- Updated
- 2021/12/16
- Product number
- 0820AB
- Product name
- 5-Cyanofuran-2-carboxylicacid
- Packaging
- 1g
- Price
- $1032
- Updated
- 2021/12/16
- Product number
- 097839
- Product name
- 5-Cyanofuran-2-carboxylic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1428
- Updated
- 2021/12/16
5-CYANOFURAN-2-CARBOXYLICACID Chemical Properties,Usage,Production
Synthesis
13529-17-4
212197-74-5
General procedure for the synthesis of 5-cyanofuran-2-carboxylic acid from 5-formylfuran-2-carboxylic acid: to a solution of 2-formyl-5-furancarboxylic acid (0.28 g, 2.0 mmol) in pyridine (5.0 mL) was added hydroxylamine hydrochloride (NH2OH-HCl) (0.27 g, 4.0 mmol). The mixture was heated to 85 °C, followed by the addition of acetic anhydride (4.0 mL). The reaction mixture was stirred at 85 °C for 3 h. The mixture was cooled to 60 °C and poured into water (25 mL). The mixture was cooled to room temperature and stirred overnight (the pH of the solution was measured to be 5-6). Impurities were extracted with a 4:1 dichloromethane/isopropanol mixture (3 x 30 mL). The aqueous layer was alkalized with a 2 N sodium hydroxide solution to a pH of about 9, and the pyridine was again extracted with a 4:1 dichloromethane/isopropanol mixture (3 x 30 mL). The aqueous solution was subsequently acidified to pH about 2 and the product was extracted with a 3:1 dichloromethane/isopropanol mixture (3 x 50 mL). The organic extracts were combined, dried over anhydrous magnesium sulfate and the solvent was evaporated to give the pure product as a light brown solid in 90% yield. NMR hydrogen spectrum (DMSO-d6): δ 13.80 (broad single peak, 1H), 7.75 (double peak, 1H), 7.40 (double peak, 1H). IR spectrum (pure): 3200, 2250, 1053, 1025, 1006 cm-1.
References
[1] Patent: WO2004/96795, 2004, A2. Location in patent: Page 25-26
[2] Patent: WO2007/123516, 2007, A1. Location in patent: Page/Page column 34
[3] Patent: US2008/51402, 2008, A1. Location in patent: Page/Page column 44
[4] Patent: WO2007/48088, 2007, A2. Location in patent: Page/Page column 82-83
[5] Patent: WO2006/47504, 2006, A1. Location in patent: Page/Page column 36
5-CYANOFURAN-2-CARBOXYLICACID Preparation Products And Raw materials
Raw materials
Preparation Products
5-CYANOFURAN-2-CARBOXYLICACID Suppliers
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View Lastest Price from 5-CYANOFURAN-2-CARBOXYLICACID manufacturers
- Product
- 5-CYANOFURAN-2-CARBOXYLICACID 212197-74-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 5-CYANOFURAN-2-CARBOXYLICACID 212197-74-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 5-CYANOFURAN-2-CARBOXYLICACID 212197-74-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-02