(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate

Product Name: (aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate
CAS No.: 179324-87-9
Chemical Name: (aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate
Synonyms: (1R)-(S)-PINANEDIOL 1-AMMONIUM TRIFLUOROACETATE-3-METHYLBUTANE-1-BORONATE;(R)-3-Methyl-1-((3aS,4S,6S,7aR)-3a,5,5-triMethylhexahydro-4,6-Methanobenzo[d][1,3,2]dioxaborol-2-yl)butan-1-aMine 2,2,2-trifluoroacetate;2,6/SUP>(R)-BoroL;6-methano-1;Bortezomib INT A;eu-(+)-PinanedioL;7aR)-Hexahydro-3a
CBNumber: CB21511721
Molecular Formula: C17H29BF3NO4
Formula Weight: 379.23
MOL File: 179324-87-9.mol

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(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate Property

Melting point:: 157-159°C
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Ethanol (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
optical activity: Consistent with structure
InChI: InChI=1/C15H28BNO2.C2HF3O2/c1-9(2)6-13(17)16-18-12-8-10-7-11(14(10,3)4)15(12,5)19-16;3-2(4,5)1(6)7/h9-13H,6-8,17H2,1-5H3;(H,6,7)/t10-,11-,12+,13-,15-;/s3
InChIKey: SRFQKJZNJYTMNI-XXOUUVOINA-N
SMILES: C(F)(F)(F)C(=O)O.C[C@@]12OB([C@@H](N)CC(C)C)O[C@]1([H])C[C@]1([H])C[C@@]2([H])C1(C)C |&1:8,11,18,21,24,r|
CAS DataBase Reference: 179324-87-9(CAS DataBase Reference)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
WGK Germany: WGK 3
HS Code: 29209090
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BCH00043
Product name: (R)-Boroleucine (1S,2S,3R,5S)-(+)-2,3-pinanediol ester trifluoroacetate
Packaging: 1G
Price: $909
Updated: 2026/03/19

TRC

Product number: P458505
Product name: (αR)-(1S,2S,3R,5S)-Pinanediol-1-amino-3-methylbutane-1-boronateTrifluoroaceticAcidSalt
Packaging: 1g
Price: $70
Updated: 2021/12/16

TRC

Product number: P458505
Product name: (αR)-(1S,2S,3R,5S)-Pinanediol-1-amino-3-methylbutane-1-boronateTrifluoroaceticAcidSalt
Packaging: 5g
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB36621
Product name: (R)-BoroLeu-(+)-pinanediol-trifluoroacetate
Packaging: 5G
Price: $200
Updated: 2021/12/16

Matrix Scientific

Product number: 076863
Product name: (R)-Boroleucine-(1S,2S,3R,5S)-(+)-pinanediol ester trifluoroacetate
Packaging: 5g
Price: $278
Updated: 2021/12/16

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(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Bortezomib intermediate

Uses

Bortezomib (B675700) intermediate. A boronic acid dipeptide derivative as proteasome inhibitors.

Pharmaceutical Applications

(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate is a intermediate of Bortezomib, a targeted anti-cancer drug used to treat multiple myeloma and mantle cell lymphoma.

(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate Suppliers

Canada 1 China 331 France 1 India 16 United Kingdom 2 United States 9 Global 360

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View Lastest Price from (aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate manufacturers

Shandong Hanjiang Chemical Co., Ltd

Product: Bortezomib Intermediates 179324-87-9
Price: US $0.00-0.00/kf
Min. Order: 1kf
Purity: 99%
Supply Ability: 1T
Release date: 2025-07-01

Sinoway Industrial co., ltd.

Product: Bortezomib Intermediates 179324-87-9
Price: US $0.00/kg
Min. Order: 2kg
Purity: ≥98%
Supply Ability: 20tons
Release date: 2024-04-03

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: (aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate 179324-87-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2024-03-29

179324-87-9, (aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetateRelated Search:

Allyl bromide Propylthiouracil Allyl glycidyl ether Sodium allylsulfonate Cuminaldehyde Cumene Cocamidopropyl betaine ((R)-3-Methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butyl)boronic acid (S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID ((S)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butyl)boronic acid Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]- AMMONIUM TRIFLUOROACETATE Trifluoroacetic acid (1S,2S,3R,5S)-(+)-2,3-Pinanediol PINANOL 85 (1S,2S,3R,5S)-(+)-2,3-PINANEDIOL BUTYLBORONATE ESTER (-)-ISOPINOCAMPHEOL (aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate

(1R)-(S)-PINANEDIOL 1-AMMONIUM TRIFLUOROACETATE-3-METHYLBUTANE-1-BORONATE

(R)-BoroLeu-(+)-Pinanediol-CF3COOH

(R)-BoroLeu-(+)-Pinanediol-CF3CO2H

(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate

(αR)-(1S,2S,3R,5S)-Pinanediol-1-amino-3-methylbutane-1-boronate Trifluoroacetate

Bortezomib Intermediate 1

(R)-BoroLeu-(+)-Pinanediol trifluoroacetate

(αR,3aS,4S,6S,7aR)-

(alphaR,3as,4s,6s,7ar)-Hexahydro-3a,8,8-triMethyl-alpha-(2-Methylpropyl)-4,6-Methano-1,3,2-benzodioxaborole-2-MethanaMine 2,2,2-trifluoroacetate

Pinanedioltrifluoroacetate salt-

(R)-3-Methyl-1-((3aS,4S,6S,7aR)-3a,5,5-triMethylhexahydro-4,6-Methanobenzo[d][1,3,2]dioxaborol-2-yl)butan-1-aMine 2,2,2-trifluoroacetate

BortezoMib I(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-triMethyl-alpha-(2-Methylpropyl)-4,6-Methano-1,3,2-benzodioxaborole-2-MethanaMine 2,2,2-trifluoroacetate

(R)-3-Methyl-1-((3aS,4S,6S,7aR)-3a,5,5-triMethylhexahydro-4,6-Methanobenzo[d][1,3,2]dioxaborol-2-yl)butan-1-aMiniuM 2,2,2-trifluoroacetate

(R)-Boroleucine-(1S,2S,3R,5S)-(+)-pinanediol ester trifluoroacetate 98%

(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-α-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate

(R)-3-Methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]-1-butanamine 2,2,2-Trifluoroacetate

BoroLeu-(+)-Pinanediol

(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.0&lt

/SUP&gt

]decan-4-yl]butan-1-amine

2,6&lt

SUP&gt

(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-α-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-

(R)-BoroL

eu-(+)-PinanedioL

(R)-Boroleucine-(1S,2S,3R,5S)-(+)-pinanediol ester trifluoroacetate

Bortezomib Intermediates

Ixazomib intermediate

(1S,2S,3R,5S)-Pinane-2,3-diol leucineboronate trifluoroacetate salt

(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methamine 2,2,2-trifluoroacetate

(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxabor

Bortezomib Intermediate A

Bortezomib INT A

(R)-BoroLeu-(+)-Pinanediol-CF3COOH N-4

(1R)-(S)-pinanediol 1-aMMoniuM trifiuoroacetate-3-Methylbutane-1-boronate

4,6-Methano-1,3,2-benzodioxaborole-2-methanamine, hexahydro-3a,8,8-trimethyl-α-(2-methylpropyl)-, (αR,3aS,4S,6S,7aR)-, 2,2,2-trifluoroacetate (1:1)

Ixazomib Impurity 28

2-benzodioxaborole-2-methanamine 2

6-methano-1

7aR)-Hexahydro-3a

8-trimethyl-alpha-(2-methylpropyl)-4

(R)-BoroLeu-(+)-Pinanediol trifluoroacetate (Bortezomib Impurity)

Bortezomib Amino R Isomer

(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methy...

(1R)-(S)-Pinanediol 1-ammonium trifluoroacetate-3-methylbutane-1-boronate (TFA)

(1R)-(S)-pinanediol-1-Ammonium Trifluoroacetate-3-methlbutane-1-boronate

(αR)-(1S,2S,3R,5S)-Pinanediol-1-amino-3-methylbutane-1-boronate Trifluoroacetic Acid Salt

(R) Pinanediol 1-amino-3-methylbutyl borate trifluoroacetate

4,6-Methano-1,3,2-benzodioxaborole-2-methanamine, hexahydro-3a,8,8-trimethyl-α-(2-methylpropyl)-, (αR,3aS,4S,6S,7aR)-,2,2,2-trifluoroacetate (1:1)

(aR,3aS,4S,6S,7aR)- hexahydro -3a,8,8- trimethyl -alpha-(2- methylpropyl) -4,6- methyl bridge -1,3,2- benzodioxolane -2- methylamine 2,2,2- trifluoroacetate

(αR,3aS,4S,6S,7aR)-hexahydro-3a,8,8-trimethyl-α-(2-methylpropyl)-4,6-Methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate (1:1)

(aR,3aS,4S,6S,7aR)-Hexahydro-3a,5,5-trimethyl-a-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine TFA

(R)-Boroleucine (1S 2S 3R 5S)-(+)-2 3-pinanediol ester trifluoroacetate.

(R)-1-Amino-3-methylbutylboronic acid pinanediol ester trifluoroacetate

(R)-BoroLeu-(+)-Pinanedioltrifluoroacetate salt

(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodiox

(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8- trimethyl-alpha-(2-methylpropyl)-4,6- methano- 1,3,2-benzodioxaborole-2-met hanamine

(R)-Boroleucine (1S,2S,3R,5S)-(+)-2,3-pinanediol ester trifluoroacetate