L-GLUTAMIC BENZYL ESTER
- Product Name
- L-GLUTAMIC BENZYL ESTER
- CAS No.
- 54322-10-0
- Chemical Name
- L-GLUTAMIC BENZYL ESTER
- Synonyms
- L-GLUTAMIC BENZYL ESTER;1,5-Pentanedioic Acid Monobenzyl Ester;1-(Phenylmethyl) Ester Pentanedioic Acid;Pentanedioic acid, 1-(phenylmethyl) ester;1,5-Pentanedioic Acid Monobenzyl Ester, 97%min
- CBNumber
- CB21511822
- Molecular Formula
- C12H14O4
- Formula Weight
- 222.24
- MOL File
- 54322-10-0.mol
L-GLUTAMIC BENZYL ESTER Property
- Boiling point:
- 153-155 °C(Press: 0.05 Torr)
- Density
- 1.1645 g/cm3
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.61±0.10(Predicted)
- Appearance
- Colorless to light yellow Solid-liquid mixture
- InChI
- InChI=1S/C12H14O4/c13-11(14)7-4-8-12(15)16-9-10-5-2-1-3-6-10/h1-3,5-6H,4,7-9H2,(H,13,14)
- InChIKey
- WRSDJJXJDSEUSQ-UHFFFAOYSA-N
- SMILES
- C(OCC1=CC=CC=C1)(=O)CCCC(O)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P319225
- Product name
- 1-(Phenylmethyl)EsterPentanedioicAcid
- Packaging
- 2.5g
- Price
- $265
- Updated
- 2021/12/16
- Product number
- 5024AJ
- Product name
- 1,5-Pentanedioicacidmonobenzylester
- Packaging
- 25g
- Price
- $1221
- Updated
- 2021/12/16
- Product number
- 54322100
- Product name
- 1,5-Pentanedioicacidmonobenzylester
- Packaging
- 25g
- Price
- $1255.28
- Updated
- 2021/12/16
- Product number
- A139671
- Product name
- 5-(Benzyloxy)-5-oxopentanoicacid
- Purity
- 97%
- Packaging
- 100g
- Price
- $1390
- Updated
- 2021/12/16
- Product number
- A139671
- Product name
- 5-(Benzyloxy)-5-oxopentanoicacid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $16
- Updated
- 2021/12/16
L-GLUTAMIC BENZYL ESTER Chemical Properties,Usage,Production
Uses
1-(Phenylmethyl) Ester Pentanedioic Acid is a useful reagent for organic synthesis.
Synthesis
108-55-4
100-51-6
54322-10-0
GENERAL METHOD: To a solution of glutaric anhydride (1.0 g, 10 mmol) in DMF (4 mL) was slowly added benzyl alcohol (0.94 mL, 9.09 mmol) and N,N-diisopropylethylamine (DIEA, 1.93 mL, 11 mmol) at 0 °C. The reaction mixture was stirred at room temperature for 12 hours. After completion of the reaction, the solvent was removed using a rotary evaporator (Speed-vac). The residue was dissolved in ethyl acetate (50 mL) and washed sequentially with saturated sodium chloride solution (10 mL x 2). The organic phase was separated and extracted with aqueous sodium bicarbonate solution (5M, 5mL x 3). The aqueous phase extracts were combined and the pH was adjusted to 4 with aqueous citric acid (5M) and extracted with ethyl acetate (30mL × 3). All ethyl acetate extracts were combined, washed with saturated sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give 1,5-glutaric acid monobenzoate as a white solid (1.66 g, 89% yield).
References
[1] Chemical Biology and Drug Design, 2018, vol. 92, # 2, p. 1403 - 1408
[2] Synthetic Communications, 2001, vol. 31, # 9, p. 1399 - 1419
[3] Journal of the American Chemical Society, 1996, vol. 118, # 29, p. 6826 - 6840
[4] Chemical Communications, 2011, vol. 47, # 17, p. 4896 - 4898
[5] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 23, p. 7507 - 7514
L-GLUTAMIC BENZYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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