4-Bromo-2,6-diethyl-pyridine
- Product Name
- 4-Bromo-2,6-diethyl-pyridine
- CAS No.
- 877133-54-5
- Chemical Name
- 4-Bromo-2,6-diethyl-pyridine
- Synonyms
- 4-Bromo-2,6-diethyl-pyridine;Pyridine, 4-bromo-2,6-diethyl-;4-Bromo-2,6-diethyl-pyridine ISO 9001：2015 REACH;Pyridine, 4-bromo-2,6-diethyl-4-Bromo-2,6-diethyl-pyridine
- CBNumber
- CB21513578
- Molecular Formula
- C9H12BrN
- Formula Weight
- 214.1
- MOL File
- 877133-54-5.mol
4-Bromo-2,6-diethyl-pyridine Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Colorless to light yellow Liquid
- CAS DataBase Reference
- 877133-54-5
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B679215
- Product name
- 4-Bromo-2,6-diethylpyridine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- B679215
- Product name
- 4-Bromo-2,6-diethylpyridine
- Packaging
- 1g
- Price
- $360
- Updated
- 2021/12/16
- Product number
- FB148700
- Product name
- 4-Bromo-2,6-diethylpyridine
- Packaging
- 1g
- Price
- $500
- Updated
- 2021/12/16
- Product number
- FB148700
- Product name
- 4-Bromo-2,6-diethylpyridine
- Packaging
- 100mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 3942AC
- Product name
- 4-Bromo-2,6-diethylpyridine
- Packaging
- 1g
- Price
- $195
- Updated
- 2021/12/16
4-Bromo-2,6-diethyl-pyridine Chemical Properties,Usage,Production
Uses
4-Bromo-2,6-diethylpyridine is a useful reactant for the synthesis of PF-?00868554 (I)?, an HCV polymerase inhibitor.
Synthesis
1035267-63-0
877133-54-5
The general procedure for the synthesis of 4-bromo-2,6-diethylpyridine using the compound (CAS:1035267-63-0) as starting material was as follows: phosphorus tribromide (2 mL) was slowly added to a solution of 4-bromo-2,6-diethylpyridine 1-oxide (4.3 g, 18.7 mmol) in dichloromethane (30 mL). The reaction mixture was stirred at room temperature for 3 h. The reaction was quenched by careful pouring into ice water. Subsequently, the reaction solution was adjusted to alkaline with 15% sodium hydroxide solution and extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 4-bromo-2,6-diethylpyridine 2.9 g in 72% yield. The product was confirmed by mass spectrometry (ESI), m/z 215 [M + 1]+.
References
[1] Patent: WO2008/76046, 2008, A1. Location in patent: Page/Page column 186-187
[2] Synlett, 2010, # 5, p. 796 - 800
4-Bromo-2,6-diethyl-pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Bromo-2,6-diethyl-pyridine manufacturers
- Product
- 4-Bromo-2,6-diethyl-pyridine 877133-54-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-04-30
- Product
- 4-Bromo-2,6-diethyl-pyridine 877133-54-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg; 2kg；10kg; 100kg
- Release date
- 2019-08-30