aderbasib

Product Name: aderbasib
CAS No.: 791828-58-5
Chemical Name: aderbasib
Synonyms: Incb7839;aderbasib;INCB 007839;Unii-V9yl6nej3g;Aderbasib (Synonyms: INCB007839;(6S,7S)-Methyl 7-(hydroxycarbamoyl)-6-(4-phenylpiperazine-1-carbonyl)-5-azaspiro[2.5]octane-5-;(6S,7S)-Methyl 7-(hydroxycarbamoyl)-6-(4-phenylpiperazine-1-carbonyl)-5-azaspiro[2.5]octane-5-car;(6S,7S)-Methyl 7-(hydroxycarbaMoyl)-6-(4-phenylpiperazine-1-carbonyl)-5-azaspiro[2.5]octane-5-carboxylate;Methyl (6S,7S)-7-(hydroxycarbamoyl)-6-(4-phenylpiperazine-1-carbonyl)-5-azaspiro[2.5]octane-5-carboxylate;5-Azaspiro2.5octane-5-carboxylicacid, 7-(hydroxyaMino)carbonyl-6-(4-phenyl-1-piperazinyl)carbonyl-, Methylester, (6S,7S)-
CBNumber: CB21518487
Molecular Formula: C21H28N4O5
Formula Weight: 416.47
MOL File: 791828-58-5.mol

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aderbasib Property

Density: 1.38
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (240.11 mM; Need ultrasonic)
pka: 9.33±0.23(Predicted)
form: Solid
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Usbiological

Product number: 474051
Product name: Aderbasib
Packaging: 100mg
Price: $3292
Updated: 2021/12/16

TRC

Product number: A291560
Product name: Aderbasib
Packaging: 25mg
Price: $5775
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17224
Product name: Aderbasib
Packaging: 50mg
Price: $787.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17224
Product name: Aderbasib
Packaging: 10mg
Price: $225
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 17322
Product name: Aderbasib
Packaging: 25mg
Price: $390
Updated: 2021/12/16

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aderbasib Chemical Properties,Usage,Production

Uses

Aderbasib is a azaspiro[2.5]octanehydroxamide derivative as inhibitor of metalloproteases for the treatment of disorders such as cancer, arthritis, cardiovascular or skin disorders.

in vivo

Aderbasib (intraperitoneal injection; 50 mg/kg; 5 days per week beginning four weeks; 2 weeks) blocks glioma growth of SU-pcGBM2 NSG mice xenografts^[1].INCB7839 can be formulated in 2% DMSO, 2% Tween 80, 48% PEG300, 48% water as a injection solution. This is for literature reference only^[1].

Animal Model:	NSG mice^[1]
Dosage:	50 mg/kg
Administration:	Intraperitoneal injection; 50 mg/kg; 5 days per week beginning four weeks; 2 weeks
Result:	Robustly inhibited growth of pediatric glioblastoma orthotopic xenografts.

IC 50

ADAM10; ADAM17

aderbasib Preparation Products And Raw materials

Raw materials

Preparation Products

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aderbasib Suppliers

Canada 1 China 37 India 4 United Kingdom 1 United States 7 Global 50

Chemsky (shanghai) International Co.,Ltd

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BOC Sciences

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Shanghai YuanYe Biotechnology Co., Ltd.

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Amadis Chemical Company Limited

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Chongqing Chemieliva Pharmaceutical Co., Ltd.

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Hefei TNJ Chemical Industry Co.,Ltd.

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HUNAN CHEMFISH SCIENTIFIC CO.,LTD

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Accela ChemBio Inc.

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791828-58-5, aderbasibRelated Search:

(6S,7S)-Methyl 7-(hydroxycarbamoyl)-6-(4-phenylpiperazine-1-carbonyl)-5-azaspiro[2.5]octane-5-car

aderbasib

(6S,7S)-7-[(Hydroxyamino)carbonyl]-6-[(4-phenyl-1-piperazinyl)carbonyl]-5-azaspiro[2.5]octane-5-carboxylic acid methyl ester

Incb7839

Unii-V9yl6nej3g

INCB 007839

(6S,7S)-Methyl 7-(hydroxycarbamoyl)-6-(4-phenylpiperazine-1-carbonyl)-5-azaspiro[2.5]octane-5-

(6S,7S)-Methyl 7-(hydroxycarbaMoyl)-6-(4-phenylpiperazine-1-carbonyl)-5-azaspiro[2.5]octane-5-carboxylate

5-Azaspiro2.5octane-5-carboxylicacid, 7-(hydroxyaMino)carbonyl-6-(4-phenyl-1-piperazinyl)carbonyl-, Methylester, (6S,7S)-

Methyl (6S,7S)-7-(hydroxycarbamoyl)-6-(4-phenylpiperazine-1-carbonyl)-5-azaspiro[2.5]octane-5-carboxylate

Aderbasib (Synonyms: INCB007839

791828-58-5

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