ChemicalBook > CAS DataBase List > 4,5-DICHLORO-2-NITROTOLUENE

4,5-DICHLORO-2-NITROTOLUENE

Product Name: 4,5-DICHLORO-2-NITROTOLUENE
CAS No.: 7494-45-3
Chemical Name: 4,5-DICHLORO-2-NITROTOLUENE
Synonyms: 4,5-DICHLORO-2-NITROTOLUENE;4,5-Dichloro-2-nitrotoluene>4,5-Dichloro-2-Methylnitrobenzene;1,2-DICHLORO-4-METHYL-5-NITRO-BENZENE;Benzene, 1,2-dichloro-4-methyl-5-nitro-
CBNumber: CB2152178
Molecular Formula: C7H5Cl2NO2
Formula Weight: 206.03
MOL File: 7494-45-3.mol

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4,5-DICHLORO-2-NITROTOLUENE Property

Melting point:: 62 °C
Boiling point:: 277.1±35.0 °C(Predicted)
Density: 1.456±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
color: White to Light yellow to Green
InChI: InChI=1S/C7H5Cl2NO2/c1-4-2-5(8)6(9)3-7(4)10(11)12/h2-3H,1H3
InChIKey: AOTWCYSQDSKAQT-UHFFFAOYSA-N
SMILES: C1(Cl)=CC([N+]([O-])=O)=C(C)C=C1Cl
CAS DataBase Reference: 7494-45-3

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Safety

HS Code: 2904.99.4700

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304IF INHALED:

P305IF IN EYES:

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P313Get medical advice/attention.

P332IF SKIN irritation occurs:

P337If eye irritation persists:

P338Remove contact lenses, if present and easy to do. Continue rinsing.

P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.

P351Rinse cautiously with water for several minutes.

P352Wash with plenty of soap and water.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: D3271
Product name: 4,5-Dichloro-2-nitrotoluene
Purity: >98.0%(GC)
Packaging: 5g
Price: $59
Updated: 2025/07/31

TCI Chemical

Product number: D3271
Product name: 4,5-Dichloro-2-nitrotoluene
Purity: >98.0%(GC)
Packaging: 25g
Price: $198
Updated: 2025/07/31

TRC

Product number: D435200
Product name: 3,4-Dichloro-6-nitrotoluene
Packaging: 1g
Price: $65
Updated: 2021/12/16

TRC

Product number: D435200
Product name: 3,4-Dichloro-6-nitrotoluene
Packaging: 2.5g
Price: $95
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD02021
Product name: 4,5-Dichloro-2-nitrotoluene
Packaging: 2g
Price: $80
Updated: 2021/12/16

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4,5-DICHLORO-2-NITROTOLUENE Chemical Properties,Usage,Production

Uses

3,4-Dichloro-6-nitrotoluene is used as a reagent in the synthesis of N-hydroxyindole-2-carboxylates as inhibitors of lactate dehydrogenase against cancer cell proliferation. 3,4-Dichloro-6-nitrotoluene is also used in the preparation of polyhalogenated quinoline C-nucleosides as potential antiviral agents.This compound is suitable for lactate dehydrogenase (LDH) related research.

Synthesis

95-75-0

7494-45-3

General procedure for the synthesis of 4,5-dichloro-2-nitrotoluene from 3,4-dichlorotoluene: Fuming nitric acid (40 mL) was slowly added dropwise to a solution of 1,2-dichloro-4-methylbenzene (20 g, 124.20 mmol) at 0 °C. After the dropwise addition, the reaction mixture was stirred at room temperature for 2 hours. Subsequently, the reaction mixture was slowly poured into 200 mL of a water/ice mixture. The precipitated solid was collected by filtration and dried under vacuum to afford 1,2-dichloro-4-methyl-5-nitrobenzene (25.2 g, 98% yield) as a yellow solid.1H-NMR (DMSO-d6, 300 MHz) δ (ppm): 8.39 (s, 1H), 7.96 (s, 1H), 2.48 (s, 3H).

References

[1] Patent: WO2018/75959, 2018, A1. Location in patent: Paragraph 0639-0640
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 10, p. 1568 - 1573
[3] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 4, p. 1966 - 1982
[4] Tetrahedron, 1998, vol. 54, # 12, p. 2953 - 2966
[5] Journal of the Chemical Society, 1902, vol. 81, p. 1349

4,5-DICHLORO-2-NITROTOLUENE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4,5-DICHLORO-2-NITROTOLUENE manufacturers

Career Henan Chemical Co

Product: 4,5-DICHLORO-2-NITROTOLUENE 7494-45-3
Price: US $5.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

7494-45-3, 4,5-DICHLORO-2-NITROTOLUENERelated Search:

Benzene, 1-bromo-5-(1,1-dimethoxyethyl)-3-(1,1-dimethylethyl)-2-methoxy- 2-(4,5-Dichloro-2-nitrophenyl)acetic acid 4,5-DICHLORO-2-NITROTOLUENE 3,4-DICHLORO-6-NITROBENZOTRIFLUORIDE 2,6-DICHLORO-3-NITROTOLUENE, 99% ** SEE,2,6-DICHLORO-3-NITROTOLUENE α,α-Dichloro-o-nitrotoluene 4,5-dichloro-2-nitrobenzonitrile 2,4-DICHLORO-6-NITROTOLUENE 3,4-DICHLORO-6-NITROTOLUENE ALPHA,4-DICHLORO-2-NITROTOLUENE,α,4-dichloro-2-nitrotoluene,a,4-Dichloro-2-nitrotoluene. 3,5-Dichloro-4-nitrotoluene METHYL 2-(4,5-DICHLORO-2-NITROPHENYL)ACETATE alpha,2-dichloro-4-nitrotoluene 2,4-dichloro-3-nitrotoluene 2,5-dichloro-3-nitrotoluene-4-sulphonic acid 2,6-Dichloro-4-Nitrotoluene α,α-Dichloro-m-nitrotoluene 2,6-dichloro-3-nitrotoluene-4-sulphonic acid

4,5-DICHLORO-2-NITROTOLUENE

1,2-DICHLORO-4-METHYL-5-NITRO-BENZENE

4,5-Dichloro-2-Methylnitrobenzene

Benzene, 1,2-dichloro-4-methyl-5-nitro-

4,5-Dichloro-2-nitrotoluene&gt

7494-45-3