ChemicalBook > CAS DataBase List > N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride

N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride

Product Name
N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride
CAS No.
2730-52-1
Chemical Name
N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride
Synonyms
Upadacitinib Impurity 86 Hydrochloride;Methyl(2,2,2-trifluoroethyl)aMine, HCl;2,2,2-Trifluoro-N-MethylethanaMine HCl;N-Methyl-N-(2,2,2-trifluoroethyl)aMine HCl;2,2,2-TRIFLUORO-N-METHYLETHANAMINIUM CHLORIDE;N-Methyl-2,2,2-trifluoroethylamine Hydrochloride;2,2,2-trifluoro-N-methylethan-1-amine hydrochloride;N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride;2,2,2-trifluoro-N-methyl-Ethanamine hydrochloride (1:1);Ethanamine, 2,2,2-trifluoro-N-methyl-, hydrochloride (1:1)
CBNumber
CB21552922
Molecular Formula
C3H7ClF3N
Formula Weight
149.54
MOL File
2730-52-1.mol
More
Less

N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride Property

Melting point:
>200 °C (sublm)(Solv: ethanol (64-17-5))
storage temp. 
Inert atmosphere,Room Temperature
form 
solid
color 
White
InChI
InChI=1S/C3H6F3N.ClH/c1-7-2-3(4,5)6;/h7H,2H2,1H3;1H
InChIKey
CUOWKFXFKFXJEL-UHFFFAOYSA-N
SMILES
C(CNC)(F)(F)F.[H]Cl
More
Less

Safety

HazardClass 
IRRITANT
HS Code 
2921199990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS001773
Product name
N-Methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride
Purity
Aldrich<SUP>CPR</SUP>
Packaging
25 mg
Price
$73.1
Updated
2025/07/31
TRC
Product number
T792695
Product name
2,2,2-Trifluoro-N-methylethanamineHydrochloride
Packaging
50mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
021250
Product name
Methyl-(2,2,2-trifluoro-ethyl)-amine hydrochloride
Packaging
500mg
Price
$78
Updated
2021/12/16
Matrix Scientific
Product number
021250
Product name
Methyl-(2,2,2-trifluoro-ethyl)-amine hydrochloride
Packaging
1g
Price
$119
Updated
2021/12/16
SynQuest Laboratories
Product number
3131-7-02
Product name
Methyl(2,2,2-trifluoroethyl)amine hydrochloride
Purity
97%
Packaging
250mg
Price
$191
Updated
2021/12/16
More
Less

N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride Chemical Properties,Usage,Production

Synthesis

815-06-5

2730-52-1

General procedure for the synthesis of N-methyl-2,2,2-trifluoroacetamide hydrochloride from N-methyl-2,2,2-trifluoroacetamide: A solution was prepared by dissolving lithium aluminum hydride (69 g, 1.8 mol) in 100 mL of ether at 100 °C. To this solution, an ether solution of 2,2,2-trifluoro-N-methylacetamide (86 g, 0.6 mol) was slowly added at 0 °C. The reaction mixture was stirred at room temperature overnight. Subsequently, sodium sulfate decahydrate was added to the mixture at -10°C and the resulting suspension was filtered. Dry HCl gas was passed into the filtrate until a white solid precipitated. The solid product was separated by filtration and recrystallized with a solvent mixture of methanol/ether to give N-methyl-2,2,2-trifluoroethylamine hydrochloride as a final white solid (73 g, 80.7% yield).

References

[1] Patent: WO2010/131145, 2010, A1. Location in patent: Page/Page column 76

N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride Suppliers

China 63 India 1 United Kingdom 1 United States 6 Global 71
Hangzhou Cedareal Technology Co., Ltd.
Tel
13858087543
Email
368073698@qq.com
Country
China
ProdList
43
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16075
Advantage
64
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
SynAsst Chemical.
Tel
021-60343070
Fax
021-35122006
Country
China
ProdList
12740
Advantage
55
Shanghai Hong-chuang Pharma Tech Co., Ltd.
Tel
18151128828
Fax
-
Email
hc-sales@foxmail.com
Country
China
ProdList
2647
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9874
Advantage
55
Shanghai Carlow Chemicals Co., Ltd.
Tel
21-33526724 18930996265
Fax
37023730
Email
info@carlowchem.com
Country
China
ProdList
1922
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Shanghai Xingui Biotechnology Co., Ltd.
Tel
15121041756
Email
xingui2022@126.com
Country
China
ProdList
9976
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66028182 18626450290
Email
yftan@aikonchem.com
Country
China
ProdList
16679
Advantage
50
JW & Y Pharmlab Co., Ltd.
Tel
021-64340559 13651849907;
Fax
021- 64345308
Email
xinyu_shi@jwypharmlab.com.cn
Country
China
ProdList
12000
Advantage
58
Changzhou Hopschain Chemical Co.,Ltd.
Tel
0519-85528066 13775048983
Fax
0519-85528066
Email
sales@hopschem.com
Country
China
ProdList
31553
Advantage
55
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9595
Advantage
55
Chengdu Xiaojia Technology Co., Ltd.
Tel
15902830537
Email
zhanghao@happysyn.com
Country
China
ProdList
3180
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Wuxi AppTec
Tel
022-59987777 13552403979
Email
jia_guoqiang@wuxiapptec.com
Country
China
ProdList
22345
Advantage
58
Nanjing SynTitan Pharmaceutical Co., Ltd.
Tel
025-57027686 17372956142
Fax
025-57027686
Email
li_lan@syntitan.com
Country
China
ProdList
9998
Advantage
58
3A Chemicals
Tel
400-668-9898
Fax
010-51582189
Email
service@3achem.com
Country
China
ProdList
20557
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
Baonuo Technology (Beijing) Co., Ltd.
Tel
010-80768195
Country
China
ProdList
78
Advantage
58
Allfluoro pharmaceutical co. ltd.
Tel
+86-400-0216110 +86-15958047586
Fax
0086-21-33275002
Email
sales@allfluoro.com
Country
China
ProdList
11385
Advantage
58
Labnetwork lnc.
Tel
+86-27-50766799 +8618062016861
Email
contact@labnetwork.com
Country
China
ProdList
19987
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30229
Advantage
58
Zhejiang Lianshuo Biotechnology Co., Ltd.
Tel
18616526224
Email
lianshuo@vip.126.com
Country
China
ProdList
9607
Advantage
58
Wuxi Kehua Biological Technology Co., Ltd.
Tel
0510-86838766 13636419861
Email
2258830676@qq.com
Country
China
ProdList
5044
Advantage
58
Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd
Tel
037188900765 18037465274
Fax
QQ3430974218
Email
enyawanglei@sina.cn
Country
China
ProdList
13966
Advantage
58
Block Chemical Technology (Shanghai) Co., LTD
Tel
021-20432219 13918097649
Fax
QQ79021576
Email
li_jinfei@acblock-lab.com
Country
China
ProdList
9673
Advantage
58
Shanghai Amico Chemicals Co. LTD
Tel
微信 17321281695 18019252918
Fax
qq:1454668768
Email
1454668768@qq.com
Country
China
ProdList
14856
Advantage
58
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Email
sales@accelachem.com
Country
China
ProdList
10467
Advantage
58
Tianjin Nuokang Pharmaceutical Technology Co., Ltd.
Tel
022-23989838 13810451150
Email
44766350@qq.com
Country
China
ProdList
2349
Advantage
58
Changzhou Kechem Bio-Scientific Co., LTD.
Tel
0519-68985668 13685222090
Fax
qq735434464
Email
sales@kechem.cn
Country
China
ProdList
26028
Advantage
58
Shanghai Botuo Biotechnology Co., LTD
Tel
16621358918
Fax
QQ:402135374
Email
botuopharma888@163.com
Country
China
ProdList
9208
Advantage
58
Wuhan YlypharmTech Co.,L
Tel
027-87212669 15927337358
Fax
027-87212669
Email
Sales@ylypharmtech.com
Country
China
ProdList
396
Advantage
58
Chongqing Kemai Material Technology Co., Ltd
Tel
17830741407
Fax
QQ：2479150351
Email
sales@chem47.com
Country
China
ProdList
1768
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44119
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
Beijing Stronger Science Co., Ltd.
Tel
0531-88924771 15614660963
Email
elsa.hang@strongerscience.com
Country
China
ProdList
10623
Advantage
58
Bide Pharmatech Ltd.
Tel
400-6005915
Email
sales@picasso-e.com
Country
China
ProdList
39653
Advantage
58
Ningbo Chemrio Chemtech Co,.Ltd.
Tel
0574-27891269 18667892864
Email
frank.xiaodong@chemriotech.com
Country
China
ProdList
3883
Advantage
58
Tianjin shanhaijing medicine technology co., ltd
Tel
19129375004 15321929114
Email
yangtzechem@163.com
Country
China
ProdList
497
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-55013243 15324716602
Email
2853979810@qq.com
Country
China
ProdList
9898
Advantage
58
Zibo Biopolar Rongchuang Pharmaceutical Co. Ltd.
Tel
0533-6092686 13371592196
Email
ddliu@bio-polar.cn
Country
China
ProdList
2229
Advantage
58
Shanghai Jieshikai Biotechnology Co. , Ltd.
Tel
021-57520305 13795461237
Email
zhuruyan@jskchem.com
Country
China
ProdList
49234
Advantage
58
Shanghai Fengji Pharmaceutical Technology Co., Ltd
Tel
15555063509
Email
153666767@qq.com
Country
China
ProdList
2751
Advantage
58
Hangzhou Bingochem Co., Ltd.
Tel
0571-8512-5372
Email
sales@bingochem.com
Country
China
ProdList
21669
Advantage
58
Z-trans Biochemistry Technology (Suzhou) Co.,Ltd
Tel
0512-66317708 13372112871
Email
huijuan@zitrans.cn
Country
China
ProdList
1993
Advantage
58

2730-52-1, N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochlorideRelated Search:

(S)-(-)-N-(TRIFLUOROACETYL)PROLYL CHLORIDE (3S)-(-)-3-(TRIFLUOROACETAMIDO)PYRROLIDINE HYDROCHLORIDE 1-(2,6-DICHLOROBENZYL)-2-OXO-6-(TRIFLUOROMETHYL)-1,2-DIHYDRO-3-PYRIDINECARBOXAMIDE 1-(3,4-DICHLOROBENZYL)-2-OXO-6-(TRIFLUOROMETHYL)-1,2-DIHYDRO-3-PYRIDINECARBOXAMIDE 4-chloro-2-[(2,2,2-trifluoroacetyl)amino]benzenecarboxylic acid 1-(4-CHLOROBENZYL)-2-OXO-6-(TRIFLUOROMETHYL)-1,2-DIHYDRO-3-PYRIDINECARBOXAMIDE 1-(3,4-DICHLOROBENZYL)-2-OXO-6-(TRIFLUOROMETHYL)-1,2-DIHYDRO-3-PYRIDINECARBONITRILE ETHYL 2-CHLORO-2-[(2,4-DICHLOROBENZOYL)AMINO]-3,3,3-TRIFLUOROPROPANOATE ETHYL 2-CHLORO-2-[(3-CHLOROBENZOYL)AMINO]-3,3,3-TRIFLUOROPROPANOATE ETHYL 2-(ACETYLAMINO)-2-CHLORO-3,3,3-TRIFLUOROPROPANOATE ETHYL 2-CHLORO-2-[(4-CHLOROBENZOYL)AMINO]-3,3,3-TRIFLUOROPROPANOATE ETHYL 2-CHLORO-3,3,3-TRIFLUORO-2-(PROPIONYLAMINO)PROPANOATE N1-(5-CHLORO-4-FLUORO-2-NITROPHENYL)-2,2,2-TRIFLUOROACETAMIDE ETHYL 2-CHLORO-2-[(2-CHLOROACETYL)AMINO]-3,3,3-TRIFLUOROPROPANOATE ETHYL 2-CHLORO-2-[(ETHOXYCARBONYL)AMINO]-3,3,3-TRIFLUOROPROPANOATE 2,3,3-TRICHLORO-1-[1-(TRIFLUOROMETHYL)-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLIN-2-YL]PROP-2-EN-1-ONE N-[1-(2,6-DICHLOROBENZYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINYL]-2,2,2-TRIFLUOROACETAMIDE 1-(4-CHLOROBENZYL)-2-OXO-6-(TRIFLUOROMETHYL)-1,2-DIHYDRO-3-PYRIDINECARBONITRILE

  • N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride
  • 2,2,2-TRIFLUORO-N-METHYLETHANAMINIUM CHLORIDE
  • Methyl(2,2,2-trifluoroethyl)aMine, HCl
  • N-Methyl-N-(2,2,2-trifluoroethyl)aMine HCl
  • 2,2,2-Trifluoro-N-MethylethanaMine HCl
  • N-Methyl-2,2,2-trifluoroethylamine Hydrochloride
  • Ethanamine, 2,2,2-trifluoro-N-methyl-, hydrochloride (1:1)
  • 2,2,2-trifluoro-N-methyl-Ethanamine hydrochloride (1:1)
  • 2,2,2-trifluoro-N-methylethan-1-amine hydrochloride
  • Upadacitinib Impurity 86 Hydrochloride
  • 2730-52-1