ChemicalBook > CAS DataBase List > 1-(4-bromo-2-methoxyphenyl)ethanone

1-(4-bromo-2-methoxyphenyl)ethanone

Product Name
1-(4-bromo-2-methoxyphenyl)ethanone
CAS No.
89368-12-7
Chemical Name
1-(4-bromo-2-methoxyphenyl)ethanone
Synonyms
4'-Bromo-2'-methoxyacetophenone;1-(4-bromo-2-methoxyphenyl)ethanone;Ethanone, 1-(4-bromo-2-methoxyphenyl)-
CBNumber
CB21555978
Molecular Formula
C9H9BrO2
Formula Weight
229.07
MOL File
89368-12-7.mol
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1-(4-bromo-2-methoxyphenyl)ethanone Property

Boiling point:
292.8±25.0 °C(Predicted)
Density 
1.421±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
solid
Appearance
White to off-white Solid
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Safety

RIDADR 
3261
HazardClass 
8
PackingGroup 
Ⅲ
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B696815
Product name
1-(4-Bromo-2-methoxyphenyl)ethanone
Packaging
250mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB143459
Product name
1-(4-Bromo-2-methoxyphenyl)ethanone
Packaging
500mg
Price
$105
Updated
2021/12/16
AK Scientific
Product number
4770AC
Product name
1-(4-Bromo-2-methoxyphenyl)ethanone
Packaging
5g
Price
$176
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB143459
Product name
1-(4-Bromo-2-methoxyphenyl)ethanone
Packaging
1g
Price
$182
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB143459
Product name
1-(4-Bromo-2-methoxyphenyl)ethanone
Packaging
2g
Price
$316
Updated
2021/12/16
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1-(4-bromo-2-methoxyphenyl)ethanone Chemical Properties,Usage,Production

Preparation

Obtained by reaction of acetic anhydride with m-bromoanisole in the presence of lithium perchlorate at 100° for 5 h (40%).

Synthesis

2398-37-0

75-36-5

89691-67-8

89368-12-7

Aluminum trichloride (1.25 eq.) was dissolved in dichloromethane and cooled to 0°C under the protection of an inert atmosphere. To this solution was added m-bromoanisole (1 eq.) dropwise over a period of 10 minutes. The reaction mixture was continued to be stirred at 0°C for 1 hour. Subsequently, a dichloromethane solution of acetyl chloride (1.05 eq.) was added dropwise. After addition, the reaction mixture was stirred at 0°C for 2 hours. Upon completion of the reaction, the mixture was quenched by careful pouring into ice water. The organic phase was separated, washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (elution gradient: petroleum ether/ethyl acetate from 98/2 to 90/10) to isolate 1-(2-bromo-4-methoxyphenyl)ethanone (colorless oil) and 1-(4-bromo-2-methoxyphenyl)ethanone (white solid). The yields were 55% and 18%, respectively. Thin layer chromatography (TLC) analysis (unfolding agent: petroleum ether/ethyl acetate 95/5) showed Rf values of 0.33 and 0.5, respectively.Nuclear magnetic resonance hydrogen spectroscopy (1H NMR, CDCl3) data were as follows:1-(2-bromo-4-methoxyphenyl)ethanone: δ 2.60 (s, 3H), 3.82 (s, 3H), 6.85 (d, 1H, J = 1.9 Hz), 7.13 (s, 1H), 7.58 (d, 1H, J = 5.0 Hz); 1-(4-bromo-2-methoxyphenyl)ethanone: δ 2.61 (s, 3H), 3.94 (s, 3H), 7.15 (m, 2H), 7.64 (d, 1H, J = 8.3 Hz).

References

[1] Patent: US2010/4159, 2010, A1. Location in patent: Page/Page column 59-60

1-(4-bromo-2-methoxyphenyl)ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-bromo-2-methoxyphenyl)ethanone Suppliers

China 68 India 3 United Kingdom 1 United States 5 Global 77
Accela ChemBio Co.,Ltd.
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China
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Shanghai Sunway Pharmaceutical Technology Co., Ltd
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Chengdu HappySyn Pharmaceutical Technology Co., Ltd.
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SuZhou ShiYa Biopharmaceuticals, Inc.
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Bide Pharmatech Ltd.
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Cool Pharm, Ltd
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Changzhou Anxuan Chemical, Co., Ltd.
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13912302692 13912302692;
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DebyeTec.com Inc.
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Tcichem, Inc.
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89368-12-7, 1-(4-bromo-2-methoxyphenyl)ethanoneRelated Search:


  • 1-(4-bromo-2-methoxyphenyl)ethanone
  • Ethanone, 1-(4-bromo-2-methoxyphenyl)-
  • 4'-Bromo-2'-methoxyacetophenone
  • 89368-12-7