ChemicalBook > CAS DataBase List > 2-(4-bromo-2-chlorophenyl)acetic acid

2-(4-bromo-2-chlorophenyl)acetic acid

Product Name
2-(4-bromo-2-chlorophenyl)acetic acid
CAS No.
916516-89-7
Chemical Name
2-(4-bromo-2-chlorophenyl)acetic acid
Synonyms
4-Bromo-2-chlorobenzeneacetic acid;Benzeneacetic acid, 4-broMo-2-chloro-;2-(4-bromo-2-chlorophenyl)acetic acid
CBNumber
CB21557053
Molecular Formula
C8H6BrClO2
Formula Weight
249.49
MOL File
916516-89-7.mol
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2-(4-bromo-2-chlorophenyl)acetic acid Property

Boiling point:
353.2±27.0 °C(Predicted)
Density 
1.720±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
3.92±0.10(Predicted)
Appearance
White to off-white Solid
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Safety

HS Code 
2918999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

TRC
Product number
B700315
Product name
2-(4-Bromo-2-chlorophenyl)aceticAcid
Packaging
10mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
J96287
Product name
2-(4-Bromo-2-chlorophenyl)aceticacid
Packaging
250mg
Price
$20
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB45416
Product name
2-(4-Bromo-2-chlorophenyl)acetic acid
Packaging
1g
Price
$40
Updated
2021/12/16
AK Scientific
Product number
J96287
Product name
2-(4-Bromo-2-chlorophenyl)aceticacid
Packaging
1g
Price
$40
Updated
2021/12/16
Apolloscientific
Product number
OR313074
Product name
4-Bromo-2-chlorophenylaceticacid
Purity
tech
Packaging
1g
Price
$41
Updated
2021/12/16
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2-(4-bromo-2-chlorophenyl)acetic acid Chemical Properties,Usage,Production

Synthesis

67197-54-0

916516-89-7

In a round-bottomed flask, 2-chloro-4-bromophenylacetonitrile (19.0 g, 82.4 mmol, 1.0 eq.) was dissolved in water (196 mL), followed by the addition of potassium hydroxide (KOH, 23.1 g, 412 mmol, 5.0 eq.). The reaction mixture was heated to reflux and stirred for 12-18 hours. After completion of the reaction, it was cooled to room temperature and washed with ethyl acetate (EtOAc) to remove organic impurities. The aqueous phase was acidified with 2N hydrochloric acid to pH < 2 and subsequently extracted with ethyl acetate (150 mL x 3). The organic phases were combined, washed with saturated sodium chloride solution (brine), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford 2-(4-bromo-2-chlorophenyl)acetic acid (S3) as brown crystals (19.1 g, 93% yield). The product characterization data were in agreement with literature reports. [20]

References

[1] Tetrahedron Letters, 2016, vol. 57, # 3, p. 449 - 451
[2] Patent: WO2013/43232, 2013, A2. Location in patent: Paragraph 00502
[3] Patent: EP2017257, 2009, A1. Location in patent: Page/Page column 21-22
[4] Patent: JP2015/231988, 2015, A. Location in patent: Paragraph 0361; 0362

2-(4-bromo-2-chlorophenyl)acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(4-bromo-2-chlorophenyl)acetic acid manufacturers

Career Henan Chemical Co
Product
2-(4-bromo-2-chlorophenyl)acetic acid 916516-89-7
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
200kg
Release date
2018-12-17

916516-89-7, 2-(4-bromo-2-chlorophenyl)acetic acidRelated Search:


  • 2-(4-bromo-2-chlorophenyl)acetic acid
  • Benzeneacetic acid, 4-broMo-2-chloro-
  • 4-Bromo-2-chlorobenzeneacetic acid
  • 916516-89-7