2-(BROMOMETHYL)-5-CHLOROBENZONITRILE

Product Name: 2-(BROMOMETHYL)-5-CHLOROBENZONITRILE
CAS No.: 50712-69-1
Chemical Name: 2-(BROMOMETHYL)-5-CHLOROBENZONITRILE
Synonyms: 4-Chlor-2-cyanobenzylbroMid;4-chloro-2-cyanobenzylbromide;2-(BROMOMETHYL)-5-CHLOROBENZONITRILE;Benzonitrile, 2-(bromomethyl)-5-chloro-
CBNumber: CB21557275
Molecular Formula: C8H5BrClN
Formula Weight: 230.49
MOL File: 50712-69-1.mol

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2-(BROMOMETHYL)-5-CHLOROBENZONITRILE Property

Boiling point:: 279.7±25.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to off-white Solid

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Safety

RIDADR: 1759
HazardClass: 8
PackingGroup: Ⅱ

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B697120
Product name: 2-(Bromomethyl)-5-chlorobenzonitrile
Packaging: 25mg
Price: $50
Updated: 2021/12/16

TRC

Product number: B697120
Product name: 2-(Bromomethyl)-5-chlorobenzonitrile
Packaging: 100mg
Price: $110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB154138
Product name: 2-(Bromomethyl)-5-chlorobenzonitrile
Packaging: 250mg
Price: $95
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB154138
Product name: 2-(Bromomethyl)-5-chlorobenzonitrile
Packaging: 500mg
Price: $165
Updated: 2021/12/16

AK Scientific

Product number: W6595
Product name: 2-(Bromomethyl)-5-chlorobenzonitrile
Packaging: 1g
Price: $184
Updated: 2021/12/16

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2-(BROMOMETHYL)-5-CHLOROBENZONITRILE Chemical Properties,Usage,Production

Synthesis

50712-70-4

50712-69-1

General procedure for the synthesis of 2-(bromomethyl)-5-chlorobenzonitrile from 5-chloro-2-methylbenzonitrile: 5-chloro-2-methylbenzonitrile (3.02 g, 20 mmol) was dissolved in 70 mL of carbon tetrachloride. N-bromosuccinimide (NBS) (3.916 g, 22 mmol) and benzoyl peroxide (BPO) (0.194 g) were added to the solution, followed by heating and refluxing the mixture for 4 hours. After completion of the reaction, the reaction mixture was filtered while hot. The filtrate was concentrated to dryness by rotary evaporation and the resulting residue was dissolved in 20 mL of chloroform. The chloroform solution was washed sequentially with saturated sodium carbonate solution and water, followed by drying with anhydrous sodium sulfate (Na2SO4). The dried solution was again concentrated to dryness by rotary evaporation and finally purified by column chromatography (using petroleum ether as eluent) to give 3.532 g of white solid product in 77.1% yield.

References

[1] Patent: US2012/289497, 2012, A1. Location in patent: Page/Page column 27-28
[2] Patent: EP2524917, 2012, A1. Location in patent: Page/Page column 30-31
[3] Patent: EP2570125, 2013, A1. Location in patent: Paragraph 0136; 0137
[4] Patent: WO2013/37960, 2013, A1. Location in patent: Page/Page column 71
[5] Arzneimittel-Forschung/Drug Research, 1973, vol. 23, # 8, p. 1090 - 1100

2-(BROMOMETHYL)-5-CHLOROBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(BROMOMETHYL)-5-CHLOROBENZONITRILE Suppliers

China 67 India 2 United Kingdom 1 United States 7 Global 77

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50712-69-1, 2-(BROMOMETHYL)-5-CHLOROBENZONITRILERelated Search:

2-(BROMOMETHYL)-5-CHLOROBENZONITRILE 5-CHLORO-2-METHYLBENZONITRILE 2-Cyanobenzyl bromide

2-(BROMOMETHYL)-5-CHLOROBENZONITRILE

4-Chlor-2-cyanobenzylbroMid

4-chloro-2-cyanobenzylbromide

Benzonitrile, 2-(bromomethyl)-5-chloro-

50712-69-1