4-bromo-1-iodo-2-methoxybenzene
Uses- Product Name
- 4-bromo-1-iodo-2-methoxybenzene
- CAS No.
- 791642-68-7
- Chemical Name
- 4-bromo-1-iodo-2-methoxybenzene
- Synonyms
- 5-BroMo-2-iodoanisole;5-Bromo-2-iodoanisole97%;5-Bromo-2-iodoanisole 97%;4-bromo-1-iodo-2-methoxybenzene;Benzene, 4-broMo-1-iodo-2-Methoxy-;4-bromo-1-iodo-2-methoxybenzene ISO 9001：2015 REACH;4-Bromo-1-iodo-2-methoxybenzene, 5-Bromo-2-iodophenyl methyl ether
- CBNumber
- CB21559370
- Molecular Formula
- C7H6BrIO
- Formula Weight
- 312.93
- MOL File
- 791642-68-7.mol
4-bromo-1-iodo-2-methoxybenzene Property
- Melting point:
- 37 °C
- Boiling point:
- 161-162 °C(Press: 8 Torr)
- Density
- 2.062±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- form
- crystalline powder
- color
- Pale orange
Safety
- HS Code
- 2909309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B687425
- Product name
- 5-Bromo-2-iodoanisole
- Packaging
- 1g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 038031
- Product name
- 5-Bromo-2-iodoanisole
- Purity
- 98%
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
- Product number
- OR46223
- Product name
- 5-Bromo-2-iodoanisole
- Purity
- 97%
- Packaging
- 1g
- Price
- $35
- Updated
- 2021/12/16
- Product number
- 2607-S-X0
- Product name
- 5-Bromo-2-iodoanisole
- Packaging
- 1g
- Price
- $39
- Updated
- 2021/12/16
- Product number
- FB46421
- Product name
- 5-Bromo-2-iodoanisole
- Packaging
- 2g
- Price
- $50
- Updated
- 2021/12/16
4-bromo-1-iodo-2-methoxybenzene Chemical Properties,Usage,Production
Uses
4-bromo-1-iodo-2-methoxybenzene is used to prepare arylsulfanylphenyloxyalkylamino acids as GlyT-1 inhibitors.
Uses
5-Bromo-2-iodoanisole is used to prepare arylsulfanylphenyloxyalkylamino acids as GlyT-1 inhibitors.
Synthesis
59557-91-4
791642-68-7
The general procedure for the synthesis of 4-bromo-1-iodo-2-methoxybenzene from 2-methoxy-4-bromoaniline was as follows: to a concentrated mixture of hydrochloric acid (1 ml) and acetic acid (15 ml), 0.75 g (11 mmol) of sodium nitrite was slowly added under ice-bath conditions, keeping the internal temperature not exceeding 10 °C. Subsequently, 2.0 g (9.0 mmol) of a solution of 4-bromo-2-methoxyaniline (purchased from Tokyo Chemical Industry Co., Ltd.) was added and stirred at room temperature for 30 min. Next, the reaction mixture was added dropwise to a 48 wt% aqueous hydrobromic acid solution (30 ml) containing 1.0 g (30 mmol) of potassium iodide and stirred for 1 hour at room temperature. Upon completion of the reaction, the reaction mixture was added batchwise to a mixture of aqueous sodium carbonate solution and dichloromethane. After confirming that the aqueous phase was basic, liquid-liquid separation was carried out. The organic phase was washed sequentially with 10 wt% aqueous sodium bisulfite, saturated aqueous sodium bicarbonate and saturated brine, dried with anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluting solvent: hexane:ethyl acetate = 100:0 to 91:9 (V/V)), the fraction containing the target compound was collected and concentrated under reduced pressure to give the title compound 2.2 g (7.2 mmol, 73% yield) as an orange solid. Mass spectrum (EI, m/z): 312 [M]+. 1H-NMR spectrum (400 MHz, CDCl3) δ: 7.61 (1H, d, J=8.3 Hz), 6.94 (1H, d, J=2.1 Hz), 6.87 (1H, dd, J=8.2, 2.1 Hz), 3.88 (3H, s).
References
[1] Organic and Biomolecular Chemistry, 2008, vol. 6, # 7, p. 1222 - 1231
[2] Patent: WO2011/86098, 2011, A1. Location in patent: Page/Page column 77
[3] Patent: WO2011/86099, 2011, A1. Location in patent: Page/Page column 66
[4] Patent: US2012/295891, 2012, A1. Location in patent: Page/Page column 31
[5] Journal of Organic Chemistry, 2011, vol. 76, # 4, p. 1013 - 1030
4-bromo-1-iodo-2-methoxybenzene Preparation Products And Raw materials
Raw materials
Preparation Products
4-bromo-1-iodo-2-methoxybenzene Suppliers
- Tel
- 5108538618
- Fax
- 86 510 85386988-8017
- suger.wang@chemfuture.com
- Country
- China
- ProdList
- 832
- Advantage
- 65
- Tel
- 0519-89803565 13776850645
- Fax
- 0519-89803575
- info4@huanlingchem.com
- Country
- China
- ProdList
- 983
- Advantage
- 68
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- marketing@accelachem.com
- Country
- China
- ProdList
- 10977
- Advantage
- 64
- Tel
- 021-31038972,31038973 17321035817
- Fax
- +86-21-51385350
- sales@harvest-chem.com
- Country
- China
- ProdList
- 2819
- Advantage
- 64
- Tel
- 13477084141; 13477084141
- Fax
- +86(27)65566697
- sales@luohuapharm.com
- Country
- China
- ProdList
- 468
- Advantage
- 60
- Tel
- 18986259541 18986259541
- Fax
- 027-87840182
- sales@3stc.com
- Country
- China
- ProdList
- 3708
- Advantage
- 58
- Tel
- 13598610367 0373-7129549
- Fax
- 0373-8369699
- 2468833170@qq.com
- Country
- China
- ProdList
- 932
- Advantage
- 58
- Tel
- 021-58170097 15801866362;
- info@topbiochem.com
- Country
- China
- ProdList
- 9520
- Advantage
- 58
- Tel
- 13524892556
- Fax
- (86) 21 51969655， QQ： 263541193
- sales-cn@potentpharm.com
- Country
- China
- ProdList
- 1011
- Advantage
- 55
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
View Lastest Price from 4-bromo-1-iodo-2-methoxybenzene manufacturers
- Product
- 4-bromo-1-iodo-2-methoxybenzene 791642-68-7
- Price
- US $0.00/kg
- Min. Order
- 20kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2025-04-01
- Product
- 4-bromo-1-iodo-2-methoxybenzene 791642-68-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12