ChemicalBook > CAS DataBase List > 4-(4-Boc-piperazin-1-yl)-3-fluoroaniline

4-(4-Boc-piperazin-1-yl)-3-fluoroaniline

Product Name
4-(4-Boc-piperazin-1-yl)-3-fluoroaniline
CAS No.
154590-35-9
Chemical Name
4-(4-Boc-piperazin-1-yl)-3-fluoroaniline
Synonyms
4-(4-Boc-1-piperazinyl)-3-fluoroaniline;4-(4-Boc-piperazin-1-yl)-3-fluoroaniline;3-Fluoro-4-[4-(Boc-amino)piperidino]aniline;4-(4-Amino-2-fluorophenyl)-1-Boc-piperazine;4-(4-Boc-piperazin-1-yl)-3-fluoroaniline ISO 9001：2015 REACH;4-(4-Amino-2-fluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester;1-Piperazinecarboxylic acid, 4-(4-amino-2-fluorophenyl)-, 1,1-dimethylethyl ester
CBNumber
CB21562066
Molecular Formula
C15H22FN3O2
Formula Weight
295.35
MOL File
154590-35-9.mol
More
Less

4-(4-Boc-piperazin-1-yl)-3-fluoroaniline Property

Boiling point:
439.6±45.0 °C(Predicted)
Density 
1.198±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
form 
solid
pka
6.67±0.10(Predicted)
Appearance
White to light yellow Solid
InChI
InChI=1S/C15H22FN3O2/c1-15(2,3)21-14(20)19-8-6-18(7-9-19)13-5-4-11(17)10-12(13)16/h4-5,10H,6-9,17H2,1-3H3
InChIKey
IULXQAJBODFBAK-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(N)C=C2F)CC1
More
Less

Safety

HS Code 
2933599590
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

More
Less

N-Bromosuccinimide Price

TRC
Product number
B809878
Product name
tert-Butyl4-(4-Amino-2-fluorophenyl)piperazine-1-carboxylate
Packaging
50mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
W3370
Product name
4-(4-Boc-piperazin-1-yl)-3-fluoroaniline
Packaging
250mg
Price
$82
Updated
2021/12/16
Matrix Scientific
Product number
046131
Product name
tert-Butyl 4-(4-amino-2-fluorophenyl)tetrahydro-1(2H)-pyrazinecarboxylate
Purity
95%
Packaging
1g
Price
$49
Updated
2021/12/16
Apolloscientific
Product number
PC8788
Product name
4-(4-Amino-2-fluorophenyl)piperazine,N1-BOCprotected
Packaging
250mg
Price
$13
Updated
2021/12/16
Matrix Scientific
Product number
046131
Product name
tert-Butyl 4-(4-amino-2-fluorophenyl)tetrahydro-1(2H)-pyrazinecarboxylate
Purity
95%
Packaging
500mg
Price
$32
Updated
2021/12/16
More
Less

4-(4-Boc-piperazin-1-yl)-3-fluoroaniline Chemical Properties,Usage,Production

Synthesis

154590-34-8

154590-35-9

Preparation of 3-4-2: [3-Fluoro-4-(Boc-piperazinyl)]aniline To 150 mL of ethyl acetate were sequentially added 9.3 g (28.6 mmol) of tert-butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate synthesized by the preparation of Example 3-4-1 and 930 mg (10 wt%) of Pd/C catalyst. The mixture was placed in a hydrogen reactor and reacted at 4 bar hydrogen pressure for 6 hours. Upon completion of the reaction, the Pd/C catalyst was removed by filtration. The filtrate was concentrated by distillation under reduced pressure and subsequently dried under vacuum at about 40 °C to give 8.22 g (yield: 97%) of the title compound. Mass spectrum (M + H)+: 296.11 1H-NMR (DMSO-d6) δ: 1.42 (s, 9H), 2.76 (br m, 4H), 3.43 (br m, 4H), 5.02 (s, 2H), 6.33 (m, 2H), 6.79 (m, 1H).

References

[1] Patent: US2011/306606, 2011, A1. Location in patent: Page/Page column 15
[2] Patent: EP2394993, 2011, A2. Location in patent: Page/Page column 23
[3] Patent: WO2005/82892, 2005, A2. Location in patent: Page/Page column 62-63
[4] Patent: WO2004/18439, 2004, A1. Location in patent: Page 31
[5] Patent: US2007/100141, 2007, A1. Location in patent: Page/Page column 27

4-(4-Boc-piperazin-1-yl)-3-fluoroaniline Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-(4-Boc-piperazin-1-yl)-3-fluoroaniline Suppliers

China 61 India 1 United Kingdom 1 United States 7 Global 70
shanghaiaoderuikanglimitedcompany
Tel
18902198068 18912886236
Email
akslichenglong@163.com
Country
China
ProdList
538
Advantage
58
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
AF Biochem Co., Ltd.
Tel
+86-028-60911900 13540204019
Email
sales@afbiochem.com
Country
China
ProdList
479
Advantage
57
Chengdu HappySyn Pharmaceutical Technology Co., Ltd.
Tel
028-85114309 18982182443
Email
yangli@happysyn.com
Country
China
ProdList
2151
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
Country
China
ProdList
2864
Advantage
52
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
ShangHai KenEn Chemical Technology Co., Ltd.
Tel
13120367189
Fax
021-50315529
Email
mychess007@163.com
Country
China
ProdList
1994
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9125
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Taian Jiaye Biotechnology Co.Ltd
Tel
13127280945
Email
285424065@qq.com
Country
China
ProdList
9976
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
Hangzhou Molcore Biopharmatech Co.,Ltd
Tel
400-711-5280 86-571-81025280
Fax
86-571-85806285
Email
sales@molcore.com
Country
China
ProdList
9967
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718; +8613336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29735
Advantage
60
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15083
Advantage
58
Suzhou Nuoouman Biological Technology Co., Ltd.
Tel
15026866316
Email
180642609@qq.com
Country
China
ProdList
4967
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Aishilun biotechnology (Shanghai) co., LTD
Tel
021-50676523 18019098996
Email
info@acelybio.com
Country
China
ProdList
3960
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-55055611 18137792234
Fax
QQ：3002694073
Email
3002694073@qq.com
Country
China
ProdList
9987
Advantage
58
Allfluoro pharmaceutical co. ltd.
Tel
+86-400-0216110 +86-15958047586
Fax
0086-21-33275002
Email
sales@allfluoro.com
Country
China
ProdList
11385
Advantage
58
Nextpeptide Inc
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
Country
China
ProdList
19908
Advantage
58
Wuxi Kehua Biological Technology Co., Ltd.
Tel
0510-86838766 13636419861
Email
2258830676@qq.com
Country
China
ProdList
5044
Advantage
58
Hubei xin bonus chemical co. LTD
Tel
86-13657291602
Fax
027-59338440
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
22963
Advantage
58
Wuhan Chemwish Technology Co., Ltd
Tel
027-67849912
Email
sales@chemwish.com
Country
CHINA
ProdList
10821
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49312
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-29-87569262 +86-15003564040
Fax
029-88380327
Email
1087@dideu.com
Country
China
ProdList
3979
Advantage
58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
Tel
+8613580539051
Email
joe@yuhengpharm.com
Country
CHINA
ProdList
21142
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
Shandong Territorial sea Biological Technology Co., LTD
Tel
15092083467
Email
18660263263@163.com
Country
China
ProdList
2811
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44119
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
Bide Pharmatech Ltd.
Tel
400-6005915
Email
sales@picasso-e.com
Country
China
ProdList
39665
Advantage
58
Zibo Biopolar Rongchuang Pharmaceutical Co. Ltd.
Tel
0533-6092686 13371592196
Email
ddliu@bio-polar.cn
Country
China
ProdList
2229
Advantage
58
Shanghai Jieshikai Biotechnology Co. , Ltd.
Tel
021-57520305 13795461237
Email
zhuruyan@jskchem.com
Country
China
ProdList
49234
Advantage
58
https://hanhongsci.com/
Tel
021-54306202 18917919676
Email
info@hanhongsci.com
Country
China
ProdList
29995
Advantage
58
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Email
syeu@accelachem.com
Country
China
ProdList
11015
Advantage
58
Young&Lively Pharminblock Co,.Ltd.
Tel
18600731423
Email
jason_gao@yl-pharminblock.com
Country
China
ProdList
1952
Advantage
58
Nantong Hanfang Biotechnology Co. , Ltd.
Tel
hanfangpharma@126.com; 18616537568
Email
hanfangpharma@126.com
Country
China
ProdList
29965
Advantage
58
Shanghai Ken chemical Technology Co.,ltd
Tel
02152215958
Email
47697177@qq.com
Country
China
ProdList
10011
Advantage
58
Shaanxi Linbang Industrial Co., Ltd
Tel
17709134430
Email
2379795542@qq.com
Country
China
ProdList
4822
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
14580
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
More
Less

View Lastest Price from 4-(4-Boc-piperazin-1-yl)-3-fluoroaniline manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-(4-Boc-piperazin-1-yl)-3-fluoroaniline 154590-35-9
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-17

154590-35-9, 4-(4-Boc-piperazin-1-yl)-3-fluoroanilineRelated Search:

FLUPENTIXOL IMPURITY F Haloperidol

  • 4-(4-Boc-piperazin-1-yl)-3-fluoroaniline
  • 4-(4-Amino-2-fluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester
  • 4-(4-Amino-2-fluorophenyl)-1-Boc-piperazine
  • 3-Fluoro-4-[4-(Boc-amino)piperidino]aniline
  • 1-Piperazinecarboxylic acid, 4-(4-amino-2-fluorophenyl)-, 1,1-dimethylethyl ester
  • 4-(4-Boc-piperazin-1-yl)-3-fluoroaniline ISO 9001：2015 REACH
  • 4-(4-Boc-1-piperazinyl)-3-fluoroaniline
  • 154590-35-9
  • C15H20FN2No2O2