1-Methyl-1H-pyrrolo[2,3-b]pyridine
- Product Name
- 1-Methyl-1H-pyrrolo[2,3-b]pyridine
- CAS No.
- 27257-15-4
- Chemical Name
- 1-Methyl-1H-pyrrolo[2,3-b]pyridine
- Synonyms
- 1-Methyl-7-azaindole;1-Methylpyrrolo[2,3-b]pyridine;1-Methyl-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 1-Methyl-
- CBNumber
- CB21564707
- Molecular Formula
- C8H8N2
- Formula Weight
- 132.16
- MOL File
- 27257-15-4.mol
1-Methyl-1H-pyrrolo[2,3-b]pyridine Property
- Boiling point:
- 112-116 °C(Press: 21 Torr)
- Density
- 1.107 g/cm3(Temp: 22 °C)
- storage temp.
- 2-8°C
- pka
- 5.35±0.30(Predicted)
- Appearance
- Light yellow to green yellow Liquid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M330398
- Product name
- 1-Methyl-1H-pyrrolo[2,3-b]pyridine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR907187
- Product name
- 1-Methyl-1H-pyrrolo[2,3-b]pyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- 3H32-1-LP
- Product name
- 1-Methyl-1H-pyrrolo[2,3-b]pyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $296
- Updated
- 2021/12/16
- Product number
- W5034
- Product name
- 1-Methyl-7-azaindole
- Packaging
- 10g
- Price
- $524
- Updated
- 2021/12/16
- Product number
- OR907187
- Product name
- 1-Methyl-1H-pyrrolo[2,3-b]pyridine
- Purity
- 95%
- Packaging
- 5g
- Price
- $555
- Updated
- 2021/12/16
1-Methyl-1H-pyrrolo[2,3-b]pyridine Chemical Properties,Usage,Production
Uses
N-Methyl-d3-7-azaindole is a labeled reactant used in the preparation of blue fluorescent amino acids as in vivo building blocks for protein engineering.
Synthesis
271-63-6
74-88-4
27257-15-4
GENERAL METHODS: Preparation of known compound 1a: 7-azaindole (2 g, 16.95 mmol) and anhydrous DMF (10 mL) were added to a dry round-bottomed flask equipped with a magnetic stirring bar under nitrogen atmosphere. The reaction mixture was cooled to 0 °C, 60% sodium hydride (1.2 eq.) was added in batches and stirring was continued for 1 h at this temperature. Subsequently, iodomethane (1.1 eq.) was added slowly and dropwise, keeping the reaction temperature at 0 °C and continuing to stir for 1 hour. Upon completion of the reaction, the reaction was quenched with ice-cold water (100 mL) and extracted with ethyl acetate (3 x 100 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 1-methyl-7-azaindole in quantitative yield.
References
[1] Beilstein Journal of Organic Chemistry, 2016, vol. 12, p. 309 - 313
[2] Green Chemistry, 2017, vol. 19, # 23, p. 5559 - 5563
[3] Organic Letters, 2013, vol. 15, # 22, p. 5718 - 5721
[4] Chemical and Pharmaceutical Bulletin, 2007, vol. 55, # 2, p. 255 - 267
[5] Journal of Natural Products, 2009, vol. 72, # 12, p. 2199 - 2202
1-Methyl-1H-pyrrolo[2,3-b]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
1-Methyl-1H-pyrrolo[2,3-b]pyridine Suppliers
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 8485655694
- sales@alchempharmtech.com
- Country
- United States
- ProdList
- 63687
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@combi-blocks.com
- Country
- United States
- ProdList
- 6618
- Advantage
- 69
- Tel
- --
- Fax
- --
- sales@matrixscientific.com
- Country
- United States
- ProdList
- 6632
- Advantage
- 80