ChemicalBook > CAS DataBase List > 4-bromo-1-methylpyrazole-3-carboxy acid

4-bromo-1-methylpyrazole-3-carboxy acid

Product Name
4-bromo-1-methylpyrazole-3-carboxy acid
CAS No.
84547-84-2
Chemical Name
4-bromo-1-methylpyrazole-3-carboxy acid
Synonyms
4-bromo-1-methylpyrazole-3-carboxy acid;1-Methyl-4-bromopyrazole-5-carboxylic acid;4-bromo-2-methyl-3-pyrazolecarboxylic acid;4-Bromo-2-methylpyrazole-3-carboxylic acid;4-Bromo-1-methylpyrazole-5-carboxylic Acid;1H-Pyrazole-5-carboxylic acid, 4-bromo-1-methyl-;4-bromo-1-methyl-1H-pyrazole-5-carboxylic acid(SALTDATA: FREE)
CBNumber
CB21569904
Molecular Formula
C5H5BrN2O2
Formula Weight
205.01
MOL File
84547-84-2.mol
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4-bromo-1-methylpyrazole-3-carboxy acid Property

Melting point:
235-236 °C
Boiling point:
347.4±27.0 °C(Predicted)
Density 
1.93±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
1.75±0.37(Predicted)
Appearance
White to off-white Solid
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Safety

HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R432725
Product name
4-BROMO-2-METHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID
Purity
Aldrich<sup>CPR</sup>
Packaging
1 unit
Price
$30.7
Updated
2025/07/31
Sigma-Aldrich
Product number
R432725
Product name
4-BROMO-2-METHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID
Purity
AldrichCPR
Packaging
5MG
Price
$29.8
Updated
2024/03/01
TRC
Product number
B697568
Product name
4-Bromo-2-methylpyrazole-3-carboxylicacid
Packaging
1g
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
027387
Product name
4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid
Purity
95+%
Packaging
1g
Price
$37
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB116123
Product name
4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid
Packaging
1g
Price
$75
Updated
2021/12/16
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4-bromo-1-methylpyrazole-3-carboxy acid Chemical Properties,Usage,Production

Synthesis

15803-02-8

124-38-9

84547-84-2

1. 600 ml of anhydrous THF was added to a 2L reaction flask under argon protection. 2. 65.4 g of diisopropylamine was added and the reaction system was subsequently cooled to -78 °C via a dry ice acetone bath. 3. 258 ml of 2.5 M n-butyllithium solution was slowly added dropwise at 0 °C. After the dropwise addition, the reaction temperature was raised to 0 °C and maintained for 0.5 h. The reaction system was then cooled to -78 °C again. 4. 80.0 g of 1-methyl-4-bromopyrazole was slowly added dropwise at -78 °C, and after the dropwise addition was completed, the reaction temperature was maintained at -78 °C for 1 hour. 5. dry carbon dioxide gas was passed into the reaction system until TLC detection showed that the reaction was complete. 6. The pH of the reaction solution was slowly adjusted to 2-3 with 1N HCl, at which time a large amount of white solid was precipitated. 7. The reaction mixture was cooled at 0 °C for 3 h, followed by filtration to collect the white solid. 8. The resulting solid was dried at 40 °C for 16 h to give 77.3 g of white solid compound 22 (4-bromo-1-methyl-1H-pyrazole-5-carboxylic acid).

References

[1] Patent: CN108264520, 2018, A. Location in patent: Paragraph 0261; 0262; 0263; 0264; 0265

4-bromo-1-methylpyrazole-3-carboxy acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-bromo-1-methylpyrazole-3-carboxy acid manufacturers

Career Henan Chemical Co
Product
4-bromo-1-methylpyrazole-3-carboxy acid 84547-84-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2019-05-24

84547-84-2, 4-bromo-1-methylpyrazole-3-carboxy acidRelated Search:

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