D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID

Product Name: D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID
CAS No.: 117414-74-1
Chemical Name: D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID
Synonyms: Midafotel;D-CPP-ENE;DCPPene,D CPP ene;(R)-CPPene (SDZ EAA 494);(R)-CPPene (SDZ EAA 494) (mM/ml), NMDA antagonist;(R)-CPPene (SDZ EAA 494), competitive NMDA antagonist;(R,E)-4-(3-PHOSPHONOPROP-2-ENYL)PIPERAZINE-2-CARBOXYLIC ACID;D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID;(2R)-4-[(E)-3-Phosphono-2-propenyl]piperazine-2β-carboxylic acid;2-Piperazinecarboxylic acid, 4-[(2E)-3-phosphono-2-propenyl]-, (2R)-
CBNumber: CB2158312
Molecular Formula: C8H15N2O5P
Formula Weight: 250.19
MOL File: 117414-74-1.mol

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D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID Property

Boiling point:: 555.6±60.0 °C(Predicted)
Density: 1.449±0.06 g/cm3(Predicted)
storage temp.: Desiccate at RT
form: Powder
pka: 1.27±0.10(Predicted)
color: White
Water Solubility: Soluble to 100 mM in water

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.04840
Product name: (R)-CPPene - CAS 117414-74-1 - Calbiochem
Packaging: 10mg
Price: $344
Updated: 2023/06/20

Tocris

Product number: 1265
Product name: D-CPP-ene
Packaging: 10
Price: $414
Updated: 2021/12/16

Usbiological

Product number: 255089
Product name: D-CPP-ene
Packaging: 10mg
Price: $715
Updated: 2021/12/16

TRC

Product number: C781465
Product name: D-CPP-ene
Packaging: 25mg
Price: $1200
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: RDL0008216
Product name: D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID
Purity: 98.00%
Packaging: 0.1G
Price: $1045
Updated: 2021/12/16

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D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

D-CPP-ene is a potent, competitive NMDA antagonist (1). NMDA antagonists such as this may increase sucrose intake through hunger satiation delay (2).

Definition

ChEBI: Midafotel is a member of the class of piperazines that is piperazine substituted by a carboxy group at position 2R and a (1E)-1-phosphonoprop-1-en-3-yl group at position 4. It is an antagonist of N-methyl-D-aspartate receptors (NMDARs) and was in clinical development by Novartis for the treatment of cognition disorders and brain injuries (now discontinued). It has a role as a NMDA receptor antagonist, a neuroprotective agent and an anticonvulsant. It is a piperazinecarboxylic acid, a monocarboxylic acid, a member of phosphonic acids, an olefinic compound and a tertiary amino compound.

Biological Activity

Potent and competitive NMDA antagonist (K i = 40 nM). Centrally active following systemic administration.

storage

Room temperature

D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID Suppliers

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117414-74-1, D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACIDRelated Search:

[2R,(-)]-4-(3-Phosphono-2-propenyl)-2-piperazinecarboxylic acid 2-Piperazinecarboxaldehyde PIPERAZINE-2-CARBOXYLIC ACID 3-(N,N-Dimethylamino)-D-alanine D-SS-(N-METHYLAMINO)ALANINE D-2,3-Diaminopropionic acid 4-METHYLPIPERAZINE-2-CARBOXYLIC ACID (R)-PIPERAZINE-2-CARBOXYLIC ACID D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID 3-(N,N-Diethylamino)-L-alanine

(R,E)-4-(3-PHOSPHONOPROP-2-ENYL)PIPERAZINE-2-CARBOXYLIC ACID

D-CPP-ENE

D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID

(2R)-4-[(E)-3-Phosphono-2-propenyl]piperazine-2β-carboxylic acid

Midafotel

2-Piperazinecarboxylic acid, 4-[(2E)-3-phosphono-2-propenyl]-, (2R)-

DCPPene,D CPP ene

(R)-CPPene (SDZ EAA 494)

(R)-CPPene (SDZ EAA 494) (mM/ml), NMDA antagonist

(R)-CPPene (SDZ EAA 494), competitive NMDA antagonist

117414-74-1

C8H15N2O5P