3-CHLORO-2-NITROBENZALDEHYDE
- Product Name
- 3-CHLORO-2-NITROBENZALDEHYDE
- CAS No.
- 22233-52-9
- Chemical Name
- 3-CHLORO-2-NITROBENZALDEHYDE
- Synonyms
- 3-CHLORO-2-NITROBENZALDEHYDE;BENZALDEHYDE,3-CHLORO-2-NITRO-
- CBNumber
- CB2161770
- Molecular Formula
- C7H4ClNO3
- Formula Weight
- 185.56
- MOL File
- 22233-52-9.mol
3-CHLORO-2-NITROBENZALDEHYDE Property
- Boiling point:
- 313.6±27.0 °C(Predicted)
- Density
- 1.485±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Solid
- color
- White to Yellow to Brown
Safety
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C382278
- Product name
- 3-Chloro-2-nitrobenzaldehyde
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FC68004
- Product name
- 3-Chloro-2-nitrobenzaldehyde
- Packaging
- 250mg
- Price
- $66.25
- Updated
- 2021/12/16
- Product number
- FC68004
- Product name
- 3-Chloro-2-nitrobenzaldehyde
- Packaging
- 500mg
- Price
- $107.5
- Updated
- 2021/12/16
- Product number
- 4654-5-1U
- Product name
- 3-Chloro-2-nitrobenzaldehyde
- Packaging
- 250mg
- Price
- $138
- Updated
- 2021/12/16
- Product number
- FC68004
- Product name
- 3-Chloro-2-nitrobenzaldehyde
- Packaging
- 1g
- Price
- $170
- Updated
- 2021/12/16
3-CHLORO-2-NITROBENZALDEHYDE Chemical Properties,Usage,Production
Uses
3-Chloro-2-nitrobenzaldehyde is a benzaldehyde derivative that contains substituents chlorine and nitro in its benzene ring structure. The compound is used as a pharmaceutical intermediate for the preparation of small molecule active inhibitors.
Synthesis
42087-81-0
22233-52-9
This embodiment relates to the synthesis of 3-chloro-2-nitrobenzaldehyde: to a stirred solution of methyl 2-nitro-3-chlorobenzoate (2.91 g, 13.5 mmol) and dichloromethane (134 mL) was slowly added diisobutylaluminum hydroxide (DIBAL-H, 16.0 mL, 16.0 mmol, 1.0 M in dichloromethane) at -78°C for a period of more than 15 minutes. After completion of the addition, stirring was continued for 10 minutes, followed by quenching the reaction with methanol (1.0 mL) and allowing the reaction mixture to warm slowly to room temperature. Next, aqueous sodium potassium tartrate (190 mL, 10% w/v) was added and the reaction mixture was stirred vigorously.After 4 h, the reaction mixture was diluted with dichloromethane (50 mL) and washed sequentially with water (3 x 100 mL) and saturated aqueous sodium bicarbonate (100 mL). The organic layer was dried over anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. The crude product was purified by recrystallization with ethyl acetate/hexane (1:3) to afford the target product 3-chloro-2-nitrobenzaldehyde (2.32 g, 12.7 mmol, 94% yield) as a white crystalline solid. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) and 13C NMR (100 MHz, CDCl3).
References
[1] Journal of Organic Chemistry, 2007, vol. 72, # 26, p. 9857 - 9865
[2] Patent: WO2008/156656, 2008, A2. Location in patent: Page/Page column 44; 181
[3] Tetrahedron, 2008, vol. 64, # 5, p. 856 - 865
3-CHLORO-2-NITROBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-CHLORO-2-NITROBENZALDEHYDE manufacturers
- Product
- 3-Chloro-2-nitrobenzaldehyde 22233-52-9
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99% min
- Supply Ability
- 100kg
- Release date
- 2025-08-18