1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL

Product Name: 1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL
CAS No.: 86215-36-3
Chemical Name: 1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL
Synonyms: CL216303;CL-216303;CL 216303;DOV216303 HCl;CL-216303 HCl;CL216303 HCl,CL 216303 HCl;1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL;1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane hychloride;1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane hydrochloride
CBNumber: CB2164988
Molecular Formula: C11H12Cl3N
Formula Weight: 264.58
MOL File: 86215-36-3.mol

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1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL Property

storage temp.: -20°C
solubility: DMSO: ≥10mg/mL
form: powder
color: white to beige
CAS DataBase Reference: 86215-36-3

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Safety

Hazard Codes: T
Risk Statements: 25-36
Safety Statements: 26-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D6446
Product name: DOV 216,303
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $132
Updated: 2025/07/31

Sigma-Aldrich

Product number: D6446
Product name: DOV 216,303
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $443
Updated: 2025/07/31

Activate Scientific

Product number: AS58986
Product name: 1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane HCl
Purity: 95+%
Packaging: 1g
Price: $425
Updated: 2021/12/16

ACHEMBLOCK

Product number: L13151
Product name: 1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexanehydrochloride
Purity: 97%
Packaging: 5G
Price: $1245
Updated: 2021/12/16

ACHEMBLOCK

Product number: L13151
Product name: 1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexanehydrochloride
Purity: 97%
Packaging: 1G
Price: $365
Updated: 2021/12/16

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1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL Chemical Properties,Usage,Production

Uses

DOV-216,303 is an antidepressant compound. DOV-216,303 inhibits the reuptake of norepinephrine (NE), serotonin (5‐HT), and dopamine (DA), with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. DOV-216,303 increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[1][2][3].

Biological Activity

Triple reuptake inhibitor (TRI); serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI); IC50 values of ~20, 14, and 78 nM, respectively.

References

[1] Skolnick P, et al. Preclinical and clinical pharmacology of DOV 216,303, a "triple" reuptake inhibitor. CNS Drug Rev. 2006 Summer;12(2):123-34. DOI:10.1111/j.1527-3458.2006.00123.x
[2] Shao L, et al. Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1438-41. DOI:10.1016/j.bmcl.2011.01.016
[3] Prins J, et al. The putative antidepressant DOV 216,303, a triple reuptake inhibitor, increases monoamine release in the prefrontal cortex of olfactory bulbectomized rats. Eur J Pharmacol. 2010 May 10;633(1-3):55-61. DOI:10.1095/biolreprod44.3.561

1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL Suppliers

China 7 United Kingdom 1 United States 10 Global 18

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86215-36-3, 1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCLRelated Search:

3-(4-chlorophenyl)piperidine C-[1-(4-CHLORO-PHENYL)-CYCLOPROPYL]-METHYLAMINE 1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL cyclopropyl(phenyl)methanamine C-[1-(3-CHLORO-PHENYL)-CYCLOPROPYL]-METHYLAMINE

1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL

1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane hydrochloride

1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane hychloride

DOV216303 HCl

CL 216303

CL216303

CL-216303

CL-216303 HCl

CL216303 HCl,CL 216303 HCl

86215-36-3

C11H12Cl3N

C11H11Cl2NHCl

C11H11Cl2NClH

pharmacetical