ChemicalBook > CAS DataBase List > 2-amino-3-chloro-5-fluorobenzoic acid
2-amino-3-chloro-5-fluorobenzoic acid
- Product Name
- 2-amino-3-chloro-5-fluorobenzoic acid
- CAS No.
- 1022961-12-1
- Chemical Name
- 2-amino-3-chloro-5-fluorobenzoic acid
- Synonyms
- Reaxys ID: 15860445;2-amino-3-chloro-5-fluorobenzoic acid;Benzoic acid, 2-amino-3-chloro-5-fluoro-
- CBNumber
- CB21682955
- Molecular Formula
- C7H5ClFNO2
- Formula Weight
- 189.57
- MOL File
- 1022961-12-1.mol
More
Less
2-amino-3-chloro-5-fluorobenzoic acid Property
- Boiling point:
- 315.2±42.0 °C(Predicted)
- Density
- 1.574±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 4.23±0.10(Predicted)
- Appearance
- Off-white to gray Solid
More
Less
Safety
- HS Code
- 2922498590
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
TRC
- Product number
- A604173
- Product name
- 2-Amino-3-chloro-5-fluoro-benzoicAcid
- Packaging
- 500mg
- Price
- $265
- Updated
- 2021/12/16
TRC
- Product number
- A604173
- Product name
- 2-Amino-3-chloro-5-fluoro-benzoicAcid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4657-7-30
- Product name
- 2-Amino-3-chloro-5-fluorobenzoic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $934
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4657-7-30
- Product name
- 2-Amino-3-chloro-5-fluorobenzoic acid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $343
- Updated
- 2021/12/16
Chemenu
- Product number
- CM129837
- Product name
- 2-amino-3-chloro-5-fluorobenzoicacid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $352
- Updated
- 2021/12/16
More
Less
2-amino-3-chloro-5-fluorobenzoic acid Chemical Properties,Usage,Production
Synthesis
446-08-2
1022961-12-1
General procedure for the synthesis of 2-amino-3-chloro-5-fluorobenzoic acid from 2-amino-5-fluorobenzoic acid: a mixture of 2-amino-5-fluorobenzoic acid (5.0 g, 32.26 mmol), N-chlorosuccinimide (NCS, 4.39 g, 32.9 mmol), and N,N-dimethylformamide (DMF, 30 mL) was stirred and reacted at room temperature for 16 hours. After completion of the reaction, the reaction solution was diluted with water (100 mL) and extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The concentrated residue was stirred with dichloromethane (100 mL) for 10 min and filtered to afford the target product 2-amino-3-chloro-5-fluorobenzoic acid (3.4 g, 56% yield) as a gray solid.LC-MS (ESI): m/z = 190.0 ([M + H]+).
References
[1] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 6, p. 3163 - 3170
[2] Patent: US2016/244432, 2016, A1. Location in patent: Paragraph 0232; 0233
2-amino-3-chloro-5-fluorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
2-amino-3-chloro-5-fluorobenzoic acid Suppliers
- Tel
- 0531-81313138 13066006660
- Fax
- QQ: 3366077777
- chibapharm@foxmail.com
- Country
- China
- ProdList
- 3991
- Advantage
- 55
- Tel
- 0513-85921823 18662920231
- Fax
- 86-513-85012876
- sales@ntminyanmedical.com
- Country
- China
- ProdList
- 4108
- Advantage
- 58
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 18662408853
- 2120408911@qq.com
- Country
- China
- ProdList
- 981
- Advantage
- 55
- Tel
- 021-64340559 13651849907;
- Fax
- 021- 64345308
- xinyu_shi@jwypharmlab.com.cn
- Country
- China
- ProdList
- 12000
- Advantage
- 58
- Tel
- 526763801 13301653310
- Fax
- +86-21-51619052
- 526763801@qq.com
- Country
- China
- ProdList
- 9279
- Advantage
- 55
- Tel
- 025-83453382-8005
- Fax
- 025-83453382
- sale@parabiochem.com
- Country
- China
- ProdList
- 9595
- Advantage
- 55
- Tel
- 400-685-9117
- Fax
- 021-51816740
- market@bepharm.com
- Country
- China
- ProdList
- 15081
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 028-65791793 18140026355
- Fax
- QQ568470422
- 568470422@qq.com
- Country
- China
- ProdList
- 9997
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 15083
- Advantage
- 58
- Tel
- 13918479294
- Fax
- -
- xiebenfa@163.com
- Country
- China
- ProdList
- 4090
- Advantage
- 58
- Tel
- 0577-64498589 15325081899
- Fax
- 0577-56994596
- sales@win-winchemical.com
- Country
- China
- ProdList
- 1085
- Advantage
- 58
- Tel
- 021-000000 13917643586;
- admin@jingshipharmatech.com
- Country
- China
- ProdList
- 9856
- Advantage
- 58
- Tel
- zhiqianbio@126.com
- Country
- China
- ProdList
- 19778
- Advantage
- 58
- Tel
- +86-400-0216110 +86-15958047586
- Fax
- 0086-21-33275002
- sales@allfluoro.com
- Country
- China
- ProdList
- 11385
- Advantage
- 58
- Tel
- +86-0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25356
- Advantage
- 58
- Tel
- +86-0086-577-64498589 +86-15355981851
- Fax
- 0086-577-56994596
- sales@win-winchemical.com
- Country
- China
- ProdList
- 14359
- Advantage
- 58
- Tel
- 0371-63284658 18135795563
- Fax
- QQ:2885349392
- 2885349392@qq.com
- Country
- China
- ProdList
- 9990
- Advantage
- 58
- Tel
- 021-50895067 18616507272
- Fax
- 021-50895067
- tensus@163.com
- Country
- China
- ProdList
- 8073
- Advantage
- 58
- Tel
- 18851912129 18851912129;
- 1670471576@qq.com
- Country
- China
- ProdList
- 800
- Advantage
- 58
- Tel
- 021-50795510 4000665055
- sales@accelachem.com
- Country
- China
- ProdList
- 10467
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58
- Tel
- 0513-0513-0513-89158300 18014392889
- Fax
- 0513-89158198
- sales@puyerbiopharma.com
- Country
- China
- ProdList
- 4956
- Advantage
- 58
- Tel
- +86-021-021-50872116 +8613122107989
- contact@fuxinpharm.com
- Country
- China
- ProdList
- 10000
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44894
- Advantage
- 58
- Tel
- 17366295326
- Fax
- QQ360829978
- puxinpharma_2017@126.com
- Country
- China
- ProdList
- 2444
- Advantage
- 58
- Tel
- 2383948258 19172820304
- 2383948258@qq.com
- Country
- China
- ProdList
- 12987
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29757
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
- Advantage
- 58
- Tel
- 18576690171
- 3001025734@qq.com
- Country
- China
- ProdList
- 8880
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 59936
- Advantage
- 58
- Tel
- 70803088888
- Fax
- QQ: 10301100
- 70803088@qq.com
- Country
- China
- ProdList
- 433
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39665
- Advantage
- 58
- Tel
- +86(21)5895 0110 19945755304
- sales@chemany.com
- Country
- China
- ProdList
- 9984
- Advantage
- 58
- Tel
- 17502510579
- 2785299132@qq.com
- Country
- China
- ProdList
- 1558
- Advantage
- 58
- Tel
- 021-57520305 13795461237
- zhuruyan@jskchem.com
- Country
- China
- ProdList
- 49234
- Advantage
- 58
- Tel
- 0512-66834346 17751187418
- sales@krl-tech.com
- Country
- China
- ProdList
- 1113
- Advantage
- 58
- Tel
- 19355912709
- 690231469@qq.com
- Country
- China
- ProdList
- 7593
- Advantage
- 58
- Tel
- 86-13349903920 13349903920
- Fax
- -
- 869523959@qq.com
- Country
- China
- ProdList
- 9626
- Advantage
- 58
- Tel
- 18627753421; 18627756402
- Fax
- QQ：3001051413
- 3001051413@qq.com
- Country
- China
- ProdList
- 20319
- Advantage
- 58
- Tel
- 17717618050
- zllg@gh-reagent.com
- Country
- China
- ProdList
- 10420
- Advantage
- 58
- Tel
- 13376082704 13376084917;
- 3930959291@qq.com
- Country
- China
- ProdList
- 2080
- Advantage
- 58
- Tel
- 17715136450
- 2439673774@qq.com
- Country
- China
- ProdList
- 15647
- Advantage
- 58
- Tel
- 51288865780
- sales@biosynth.com
- Country
- China
- ProdList
- 6051
- Advantage
- 58
- Tel
- 18961173882
- mia@psfscience.com
- Country
- China
- ProdList
- 999
- Advantage
- 58
- Tel
- 18270980682
- mmwang@sunwaypharm.cn
- Country
- China
- ProdList
- 1790
- Advantage
- 58
- Tel
- +86-51266834346 +86-17751128648
- sales@krl-tech.com
- Country
- China
- ProdList
- 942
- Advantage
- 58
- Tel
- +undefined17612118332
- Lucky@hanhonggroup.com
- Country
- China
- ProdList
- 5844
- Advantage
- 58
- Tel
- +86-571-87711850
- market18@leapchem.com
- Country
- China
- ProdList
- 43339
- Advantage
- 58