N-CBZ-N,N-BIS(2-CHLOROETHYL)AMINE
- Product Name
- N-CBZ-N,N-BIS(2-CHLOROETHYL)AMINE
- CAS No.
- 72791-76-5
- Chemical Name
- N-CBZ-N,N-BIS(2-CHLOROETHYL)AMINE
- Synonyms
- benzyl bis(2-chloroethyl)carbamate;Benzyl bis(2-chloroethyl);N-CBZ-N,N-BIS(2-CHLOROETHYL)AMINE;benzyl N,N-bis(2-chloroethyl)carbamate;bis(2-chloroethyl)carbamic acid benzyl ester;CarbaMic acid,N,N-bis(2-chloroethyl)-, phenylMethyl ester
- CBNumber
- CB2174385
- Molecular Formula
- C12H15Cl2NO2
- Formula Weight
- 276.16
- MOL File
- 72791-76-5.mol
N-CBZ-N,N-BIS(2-CHLOROETHYL)AMINE Property
- Boiling point:
- 376.9±42.0 °C(Predicted)
- Density
- 1.245±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -1.78±0.70(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- C227883
- Product name
- N-Cbz-N,N-bis(2-chloroethyl)amine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C227883
- Product name
- N-Cbz-N,N-bis(2-chloroethyl)amine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C227883
- Product name
- N-Cbz-N,N-bis(2-chloroethyl)amine
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- HCH0368580
- Product name
- BENZYL BIS-(2-CHLOROETHYL)CARBAMATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.12
- Updated
- 2021/12/16
- Product number
- A175871
- Product name
- Benzylbis(2-chloroethyl)carbamate
- Purity
- 95%
- Packaging
- 100g
- Price
- $1069
- Updated
- 2021/12/16
N-CBZ-N,N-BIS(2-CHLOROETHYL)AMINE Chemical Properties,Usage,Production
Synthesis
821-48-7
501-53-1
72791-76-5
Bis(2-chloroethyl)amine hydrochloride (5 g, 0.028 mol) was suspended in 30 ml of anhydrous dichloromethane under cooling in an ice water bath and stirring. Benzyl chloroformate (5.1 g, 0.03 mol) was added slowly dropwise with a controlled dropwise time of 10 min. Subsequently, triethylamine (6.46 g, 0.063 mol) was added dropwise over 1 hour. The reaction mixture was continued to be stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction was quenched by the addition of water (10 ml) and stirring was continued for 15 minutes. The organic phase (dichloromethane layer) was separated and washed sequentially with 1M HCl (10 ml) and saturated saline (10 ml), dried anhydrically and concentrated under reduced pressure to give the oily target product benzyl bis(dichloroethyl)aminocarboxylate (7 g, 95.5% yield, 80% purity).
References
[1] Organic Letters, 2009, vol. 11, # 2, p. 449 - 452
[2] Patent: US2009/143582, 2009, A1. Location in patent: Page/Page column 8
[3] Patent: US2015/105384, 2015, A1. Location in patent: Paragraph 0174; 0175
[4] Patent: WO2016/57779, 2016, A2. Location in patent: Page/Page column 63
[5] Patent: KR2017/43091, 2017, A. Location in patent: Paragraph 0693-0696
N-CBZ-N,N-BIS(2-CHLOROETHYL)AMINE Preparation Products And Raw materials
Raw materials
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