Boc-Beta-iodo-Ala-Ome

Product Name: Boc-Beta-iodo-Ala-Ome
CAS No.: 93267-04-0
Chemical Name: Boc-Beta-iodo-Ala-Ome
Synonyms: N-(TERT-BUTOXYCARBONYL)-3-IODO-L-ALANINE METHYL ESTER;Boc-β-iodo-Ala-OMe;A-OME;EOS-61913;-iodo-Ala-OMe;Boc-β-I-Ala-OMe;BOC-BETA-IODO-AL;Boc-Ala(3-I)-OMe;BOC-L-ALA(3-I)-OME;BOC-SS-IODO-ALA-OME
CBNumber: CB2177139
Molecular Formula: C9H16INO4
Formula Weight: 329.13
MOL File: 93267-04-0.mol

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Boc-Beta-iodo-Ala-Ome Property

Melting point:: 50-52 °C(lit.)
Boiling point:: 356.5±32.0 °C(Predicted)
Density: 1.551±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: soluble in Methanol
pka: 10.44±0.46(Predicted)
form: Powder
color: White to yellow
optical activity: [α]22/D 4°, c = 2 in methanol
Water Solubility: Soluble in water and 1% acetic acid.
Sensitive: Light Sensitive
BRN: 4422011
InChI: InChI=1S/C9H16INO4/c1-9(2,3)15-8(13)11-6(5-10)7(12)14-4/h6H,5H2,1-4H3,(H,11,13)/t6-/m0/s1
InChIKey: UGZBFCCHLUWCQI-LURJTMIESA-N
SMILES: C(OC)(=O)[C@H](CI)NC(OC(C)(C)C)=O
CAS DataBase Reference: 93267-04-0

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Safety

Safety Statements: 24/25
WGK Germany: 3
F: 8
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 426024
Product name: Boc-β-iodo-Ala-OMe
Purity: 99%
Packaging: 1g
Price: $53.4
Updated: 2023/06/20

TCI Chemical

Product number: B4044
Product name: N-(tert-Butoxycarbonyl)-3-iodo-L-alanine Methyl Ester
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: B4044
Product name: N-(tert-Butoxycarbonyl)-3-iodo-L-alanine Methyl Ester
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $121
Updated: 2025/07/31

TRC

Product number: B810848
Product name: N-(tert-Butoxycarbonyl)-3-iodo-L-alanine Methyl Ester
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B810848
Product name: N-(tert-Butoxycarbonyl)-3-iodo-L-alanine Methyl Ester
Packaging: 100mg
Price: $60
Updated: 2021/12/16

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Boc-Beta-iodo-Ala-Ome Chemical Properties,Usage,Production

Uses

N-Boc-3-iodo-L-alanine methyl ester is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

2766-43-0

93267-04-0

General procedure for the synthesis of methyl (R)-2-((tert-butoxycarbonyl)amino)-3-iodopropionate from methyl Boc-L-serinate: a mixture of triphenylphosphine (131 g, 0.500 mol) and imidazole (34 g, 0.50 mol) in dichloromethane (600 mL) was cooled to 0 °C and over 0.5 h iodine was added in batches (127 g, 0.50 mol). The cooling bath was removed and the mixture was stirred for 0.5 hours. After cooling the mixture to 0 °C again, a solution of methyl (R)-2-((tert-butoxycarbonyl)amino)-3-hydroxypropionate (73 g, 0.33 mol) in dichloromethane (300 mL) was slowly added dropwise. After dropwise addition, the cooling bath was removed and the mixture was warmed to room temperature and stirred for 1.5 hours. The reaction mixture was filtered and the filtrate was concentrated to remove most of the solvent. Methyl tert-butyl ether (400 mL) was added to the residue and filtered to remove triphenylphosphine oxide. The filtrate was concentrated and the residue was purified by rapid column chromatography on silica gel to afford methyl (R)-2-((tert-butoxycarbonyl)amino)-3-iodopropionate (74.0 g, 68% yield) as a colorless solid.

References

[1] Journal of Organic Chemistry, 2009, vol. 74, # 17, p. 6792 - 6796
[2] Organic Letters, 2003, vol. 5, # 24, p. 4599 - 4602
[3] Organic Letters, 2011, vol. 13, # 10, p. 2614 - 2617
[4] Tetrahedron, 2017, vol. 73, # 42, p. 6085 - 6091
[5] Tetrahedron Letters, 2007, vol. 48, # 16, p. 2857 - 2859

Boc-Beta-iodo-Ala-Ome Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-Beta-iodo-Ala-Ome Suppliers

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View Lastest Price from Boc-Beta-iodo-Ala-Ome manufacturers

Career Henan Chemical Co

Product: BOC-BETA-IODO-ALA-OME 93267-04-0
Price: US $1.00/kg
Min. Order: 1kg
Purity: 97%-99%
Supply Ability: as request
Release date: 2018-12-23

93267-04-0, Boc-Beta-iodo-Ala-OmeRelated Search:

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N-(TERT-BUTOXYCARBONYL)-3-IODO-L-ALANINE METHYL ESTER

L-N-BOC-3-IODOALANINE METHYL ESTER

BOC-3-IODO-L-ALANINE METHYL ESTER

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BOC-SS-IODO-ALA-OME

N-(TERT-BUTOXYCARBONYL)-3-IODO-L-ALININE METHYL ESTER

Boc-3-iodo-L-alanine methyl ester, N-(tert-Butoxycarbonyl)-3-iodo-L-alanine methyl ester

N-boc-3-iodo-L-alanineMethylester

3-Iodo-L-alanine methyl ester, N-BOC protected

-iodo-Ala-OMe

Boc-beta-iodo-ala-oMe“=LOWER(A1)

(2R)-3-Iodo-2-(tert-butoxycarbonylamino)propanoic acid methyl ester

Boc-beta-iodo-Ala-OMe 99%

BOC-3-Iodo-L-alanine methyleester

EOS-61913

(Tert-Butoxy)Carbonyl β-Iodo-Ala-OMe

L-Alanine,N-[(1,1-dimethylethoxy)carbonyl]-3-iodo-, methyl ester

(R)-N-Boc-Beta-Iodo-AlaOMe

Boc-β-iodo-Ala-Ome, 98%, Boc-amino acids

tert-Butyl (R)-1-(methoxycarbonyl)-2-iodoethylcarbamate

(2R)-3-iodo-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid methyl ester

Methyl(2R)-2-{[(tert-butoxy)carbony]Amino}-3-Iodopropanoate

N-(tert-Butoxycarbonyl)-3-iodo-L-alanine Methyl Ester &gt

A-OME

BOC-BETA-IODO-AL

N-(TERT-BUTOXYCARBONYL)-3-IODO-L-ALANINE METHYL ESTE

L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-3-iodo-, methyl ester

Boc-β-iodo-Ala-OMe

Boc-Ala(3-I)-OMe

BOC-BETA-IODO-ALA-OME USP/EP/BP

methyl (2R)-3-iodo-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate

93267-04-0 BOC-BETA-IODO-ALA-OME

Boc-β-I-Ala-OMe

Methyl (R)-2-(N-BOC-amino)-3-iodo-propanoate

methyl (R)-2-amino-3-iodopropanoate

Closantel Sodium-13C6

Boc-β-iodo-Ala-OMe 98%

(R)-METHYL 2-(TERT-BUTOXYCARBONYLAMINO)-3-IODOPROPANOATE

(R)-METHYL 2-(TERT-BUTOXYCARBONYLAMINA)-3-IODOPROPANAATE

(R)-2-((tert-butoxycarbonyl)amino)-3-iodopropanoate

93267-04-0

93267-04-0/889670-02-4

C9H16INO4

Alanine Derivatives

Unnatural Amino Acid Derivatives

Specialty Synthesis

Peptide Synthesis

amino acids

chiral

β-Alanine [β-Ala]

Boc-Amino Acids and Derivative

Boc-Amino acid series