5-chloro-N-methylpyridin-2-amine

Product Name: 5-chloro-N-methylpyridin-2-amine
CAS No.: 4214-80-6
Chemical Name: 5-chloro-N-methylpyridin-2-amine
Synonyms: UKRORGSYN-BB BBR-009506;5-Chloro-2-MethylaMinopyridine;5-Chloro-2-(MethylaMino)pyridine;5-chloro-N-methylpyridin-2-amine;5-Chloro-N-methyl-2-pyridinamine;5-Chloro-N-Methyl-2-pyridineaMine;2-PyridinaMine, 5-chloro-N-Methyl-;5-Chloro-N-methylpyridin-2-ylamine;(5-Chloro-pyridin-2-yl)-methyl-amine
CBNumber: CB21778216
Molecular Formula: C6H7ClN2
Formula Weight: 142.59
MOL File: 4214-80-6.mol

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5-chloro-N-methylpyridin-2-amine Property

Melting point:: 63-65°C
Boiling point:: 247℃
Density: 1.250
Flash point:: 103℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO, Methanol
form: Solid
pka: 5.00±0.10(Predicted)
color: Off-White
InChI: InChI=1S/C6H7ClN2/c1-8-6-3-2-5(7)4-9-6/h2-4H,1H3,(H,8,9)
InChIKey: KSISYWKRGRATSK-UHFFFAOYSA-N
SMILES: C1(NC)=NC=C(Cl)C=C1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C369060
Product name: 5-Chloro-2-methylaminopyridine
Packaging: 500mg
Price: $80
Updated: 2021/12/16

Apolloscientific

Product number: OR927031
Product name: 5-Chloro-N-methylpyridin-2-amine
Purity: 98%
Packaging: 5g
Price: $320
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20026
Product name: 5-Chloro-2-methylaminopyridine
Packaging: 500mg
Price: $370
Updated: 2021/12/16

AK Scientific

Product number: Y9067
Product name: (5-Chloropyridin-2-yl)methanamine
Packaging: 5g
Price: $384
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0367324
Product name: 5-CHLORO-N-METHYLPYRIDIN-2-AMINE
Purity: 95.00%
Packaging: 5MG
Price: $498.27
Updated: 2021/12/16

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5-chloro-N-methylpyridin-2-amine Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

5-Chloro-2-methylaminopyridine is used in the preparation of aminosulfuranes with N-heterocyclic groups.

Synthesis

1072-98-6

7318-81-2

4214-80-6

GENERAL METHOD: Copper(II) acetate (0.550 g, 3.03 mmol) was added to a solution of 2-amino-5-chloropyridine (1.22 mmol) and pyridine (0.34 mL, 4.24 mmol) in dioxane (15 mL). The mixture was stirred for 15 min, methylboronic acid (0.181 g, 3.03 mmol) was added and the reaction was refluxed until the 2-amino-5-chloropyridine was completely consumed (reaction time monitored by TLC analysis, 1.5-18 h). The reaction mixture was allowed to cool to room temperature, filtered through diatomaceous earth and the solvent was evaporated. The residue was purified by fast chromatography (elution gradient: 0→50% ethyl acetate/hexane) to give 5-chloro-N-methylpyridin-2-amine (162). Preparation of 5-chloro-N-methylpyridin-2-amine (162): compound 162 was prepared from 2-amino-5-chloropyridine (160) according to the above method F. 73 mg of brown powder was obtained in 42% yield. 1H NMR (500 MHz, CDCl3) δ 2.90 (s, 3H), 4.79 (br s, 1H), 6.33 (d, J = 8.9 Hz, 1H), 7.38 (dd, J = 2.6, 8.9 Hz, 1H), 8.02 (d, J = 2.6 Hz, 1H). 13C NMR (126 MHz, CDCl3) δ 29.22, 106.90, 119.44, 137.27, 146.26, 157.88. LC-MS (M + H+) calculated value C6H7ClN2 143, measured value 143.

References

[1] Patent: WO2014/100833, 2014, A1. Location in patent: Paragraph 0081; 0233

5-chloro-N-methylpyridin-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-chloro-N-methylpyridin-2-amine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Chloro-N-methyl-2-pyridineamine 4214-80-6
Price: US $20.00-100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2024-08-09

Career Henan Chemical Co

Product: 5-chloro-N-methylpyridin-2-amine 4214-80-6
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-17

4214-80-6, 5-chloro-N-methylpyridin-2-amineRelated Search:

6-(5-Chloro-2-pyridyl)-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione Zopiclone N-(5-CHLORO-2-PYRIDINYL)-4-FLUORO-BENZAMIDE 6-CHLORO-1,3-DIHYDRO-2H-IMIDAZO[4,5-B]PYRIDIN-2-ONE N-(5-CHLORO-2-PYRIDINYL)-BENZAMIDE 4-CHLORO-N-(5-CHLORO-2-PYRIDINYL)BUTANAMIDE 2-CHLORO-N-(5-CHLOROPYRIDIN-2-YL)ACETAMIDE 1-[5-CHLORO-3-(TRIFLUOROMETHYL)-2-PYRIDYL]-1-METHYLHYDRAZINE 4-bromo-N-(5-chloropyridin-2-yl)benzamide CHEMBRDG-BB 5222291 7-CHLORO-2H-PYRIDO[3,2-B]-1,4-OXAZIN-3(4H)ONE DIETHYL 2-([(5-CHLORO-2-PYRIDINYL)AMINO]METHYLENE)MALONATE 2-[4-[5-CHLORO-3-(TRIFLUOROMETHYL)-2-PYRIDYL]PIPERAZINO]ETHAN-1-OL 5-chloro-N-[(2-chlorophenyl)methyl]pyridin-2-amine 3-([(5-CHLORO-2-PYRIDINYL)AMINO]CARBONYL)-2-PYRAZINECARBOXYLIC ACID N-(5-chloro-2-pyridinyl)-2-methylbenzamide 4-((5-CHLOROPYRIDIN-2-YL)AMINO)-4-OXOBUTANOIC ACID 2-bromo-N-(5-chloropyridin-2-yl)benzamide

2-PyridinaMine, 5-chloro-N-Methyl-

5-chloro-N-methylpyridin-2-amine

UKRORGSYN-BB BBR-009506

5-Chloro-2-(MethylaMino)pyridine

5-Chloro-2-MethylaMinopyridine

5-Chloro-N-Methyl-2-pyridineaMine

5-Chloro-N-methyl-2-pyridinamine

(5-Chloro-pyridin-2-yl)-methyl-amine

5-Chloro-N-methylpyridin-2-ylamine

4214-80-6