Propafenone

ChemicalBook > CAS DataBase List > Propafenone

Product Name: Propafenone
CAS No.: 54063-53-5
Chemical Name: Propafenone
Synonyms: C07381;WZ-884-642;WZ-884-643;PROPAFENONE;AKOS 215-08;Propafenonum;Propafenone-d;Propafenone USP;(RS)-Propafenone;PROPAFENONE HCL USP
CBNumber: CB2183169
Molecular Formula: C21H27NO3
Formula Weight: 341.44
MOL File: 54063-53-5.mol

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Propafenone Property

Boiling point:: 519.6±50.0 °C(Predicted)
Density: 1.096±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 68 mg/mL (199.16 mM);Ethanol: 41 mg/mL (120.08 mM)
form: Solid
pka: pKa 9.27 (Uncertain)
color: White to Off-White
Water Solubility: 759.9ug/L(22.5 ºC)
CAS DataBase Reference: 54063-53-5(CAS DataBase Reference)
NIST Chemistry Reference: Propafenone(54063-53-5)

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Safety

Hazard Codes: T
Risk Statements: 46-22
Safety Statements: 53-36/37/39-45
WGK Germany: 3
RTECS: UH2833000
Hazardous Substances Data: 54063-53-5(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: P767403
Product name: Propafenone
Packaging: 500mg
Price: $60
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003944
Product name: PROPAFENONE
Purity: 95.00%
Packaging: 10MG
Price: $450.45
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003944
Product name: PROPAFENONE
Purity: 95.00%
Packaging: 10G
Price: $1334.03
Updated: 2021/12/16

AHH

Product number: API-1621
Product name: Propafenone
Purity: 98%
Packaging: 100g
Price: $350
Updated: 2021/12/16

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Propafenone Chemical Properties,Usage,Production

Uses

Cardiac depressant (anti-arrhythmic).

Definition

ChEBI: An aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydroch oride salt in the management of supraventricular and ventricular arrhythmias.

brand name

Rythmol (Reliant);Arythmol;Nofenan;Nofenon;Nomorytmin;Normotrytmin (r) 10 mg;Prolekofen;Retmonorm;Ryhmonorma;Rythmole;Rytmonorm.

World Health Organization (WHO)

Propafenone, a membrane-stabilizing antiarrhythmic agent, was introduced into medicine in the mid 1980s. Shortly afterwards, its use became associated with cases of severe cardiac arrhythmias, which led to notable restrictions in the drug's indications in at least two countries. See also WHO comment for flecainide.

General Description

Propafenone, 2-[2＇-hydroxy-3-(propylamino)propoxy]-3-phenylpropiophenone (Rythmol), a classIC antiarrhythmic drug, contains a chiral center and is marketedas the racemic mixture. Therapy with the racemicmixture of propafenone produces effects that can be attributedto both (S) and (R) enantiomers. Although (R) and (S)enantiomers exert similarNa⁺channel–blocking effects, the(S) enantiomer also produces aβ-adrenergic blockade. As aresult, the (S) enantiomer is reported to be 40-fold morepotent than the (R) enantiomer as an antiarrhythmic agent.The enantiomers also display stereoselective dispositioncharacteristics. The (R) enantiomer is cleared more quickly.Hepatic metabolism is polymorphic and determined genetically.Ten percent of Caucasians have a reduced capacity tohydroxylate the drug to form 5-hydroxypropafenone. Thispolymorphic metabolism accounts for the interindividualvariability in the relationships between dose and concentrationand, thus, variability in the pharmacodynamic effects ofthe drug. The 5-hydroxy metabolites of both enantiomersare as potent as the parent compound in blocking Na⁺channels.Propafenone also depresses the slow inward current ofCa2⁺ions.

Mechanism of action

Propafenone has not only pronounced class I effects but also class II (structure related) and class IV activities . Accordingly, it has a broad spectrum of activity against ventricular and supraventricular arrhythmias.

Clinical Use

Propafenone has been used for acute termination orlong-term suppression of ventricular arrhythmias. It isbound in excess of 95% to 1-acid glycoprotein in theplasma. It is absorbed effectively, but bioavailability is estimatedto be less than 20% because of first-pass metabolism.Less than 1% is eliminated as unchanged drug. Therapywith propafenone may produce effects that can be attributedto both (S) and (R) enantiomers. Thus, the effects may bemodulated because of an enantiomer–enantiomer interactionwhen patients are treated with the racemate.

Side effects

Concurrent administration of propafenone with digoxin, warfarin, propranolol, or metoprolol increases the serum concentrations of the latter four drugs. Cimetidine slightly increases the propafenone serum concentrations. Additive pharmacological effects can occur when lidocaine, procainamide, and quinidine are combined with propafenone.
As with other members of class IC, propafenone may interact in an unfavorable way with other agents that depress A-V nodal function, intraventricular conduction, or myocardial contractility. Overall, 21 to 32% of patients have adverse effects. The most common are dizziness or light-headedness, metallic taste, nausea, and vomiting; the most serious are proarrhythmic events.

Precautions

Propafenone is contraindicated in the presence of severe or uncontrolled congestive heart failure; cardiogenic shock; sinoatrial, A-V, and intraventricular disorders of conduction; and sinus node dysfunction, such as sick sinus syndrome. Other contraindications include severe bradycardia, hypotension, obstructive pulmonary disease, and hepatic and renal failure. Because of its weak β-blocking action, propafenone may cause possible dose-related bronchospasm.This problem is greatest in patients who are slow metabolizers.

Propafenone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Propafenone manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Propafenone 54063-53-5
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-05-11

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Propafenone 54063-53-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500kg/month
Release date: 2021-07-22

XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD

Product: Propafenone 54063-53-5
Price: US $20.00/KG
Min. Order: 1KG
Purity: 99.9%
Supply Ability: 500MT/month
Release date: 2022-01-19

54063-53-5, PropafenoneRelated Search:

PHENYL VALERATE 4-Methoxyphenylacetone 1,3-Dihydroxyacetone CHLOROPHOSPHONAZO III Hydroxyacetone Metoprolol Amiodarone Phenylacetone Propiophenone Propafenone Hydrochloride Phenylacetic acid PROPAFENONE-D5 HCL 5-HYDROXY PROPAFENONE HYDROCHLORIDE (R)-(+)-PROPAFENONE HYDROCHLORIDE (+)-(R)-Propafenone,(R)-Propafenone (-)-(S)-Propafenone,(S)-Propafenone LG 6-102 PROPAFENONE-D5

1-[2-(2-hydroxy-3-propylamino-propoxy)phenyl]-3-phenyl-propan-1-one

AKOS 215-08

PROPAFENONE

1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanon

1-[2-[2-oxo-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone

(RS)-Propafenone

1-Propanone, 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl- (9CI)

Propafenone USP

Propafenone (base and/or unspecified salts)

PROPAFENONE HCL USP

2'-[2-Hydroxy-3-(propylamino)propoxy]-β-phenylpropiophenone

WZ-884-642

WZ-884-643

β-Phenyl-2'-[3-(propylamino)-2-hydroxypropoxy]propiophenone

C07381

5-OH-Propafenone-D5

N-(carboxypheny)guanidine hydrochloride

1-(2-(2-Hydroxy-3-(propylamino)

-3-phenylpropan-1-one

1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone

Propafenonum

Propafenone USP/EP/BP

PropafenoneQ: What is Propafenone Q: What is the CAS Number of Propafenone Q: What is the storage condition of Propafenone Q: What are the applications of Propafenone

Propafenone-d

54063-53-5

C21H27N03HCl

C21H27NO3

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Cell Biology

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Monovalent Ion Channels

Ion Channels

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Voltage-gated Ion Channels

Propafenone

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Isotopically Labeled Pharmaceutical Reference Standard

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