(3S,4S)-1-Benzylpyrrolidine-3,4-diol Property

Melting point:

94-100 °C

alpha 

33.6 º (c=1.05% in methanol)

Boiling point:

329.46°C (rough estimate)

Density 

1.0945 (rough estimate)

refractive index 

1.5041 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Powder, Crystals, and/or Chunks

pka

13.99±0.40(Predicted)

color 

Off-white to yellow to light brown

optical activity

[α]20/D +33.6±3°, c = 1.05% in methanol

BRN 

4992458

InChIKey

QJRIUWQPJVPYSO-QWRGUYRKSA-N

CAS DataBase Reference

90365-74-5(CAS DataBase Reference)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

3

F 

10-34

HS Code 

29339900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

(3S,4S)-1-Benzylpyrrolidine-3,4-diol Chemical Properties,Usage,Production

Chemical Properties

off-white to light brown powder or needles

Uses

(3S,4S)-(+)-1-Benzyl-3,4-pyrrolidinediol can be used:

• As a building block for the preparation of novel chiral crown ethers.
• As an intermediate in the synthesis of (3R,4R)1-benzyl-4-fluoropyrrolidin-3- amine.
• As an intermediate in the preparation of 3-hydroxy-4-pyrrolidinyl analogs of nucleobases.