1-Boc-3-(cyanomethyl)azetidine
- Product Name
- 1-Boc-3-(cyanomethyl)azetidine
- CAS No.
- 142253-58-5
- Chemical Name
- 1-Boc-3-(cyanomethyl)azetidine
- Synonyms
- 1-Boc-3-(cyanomethyl)azetidine;2-(1-Boc-3-azetidinyl)acetonitrile;tert-butyl 3-(cyanomethyl)azetidine-1-carboxylate;3-(Cyanomethyl)-1-azetidinecarboxylic acid tert-butyl ester;3-(Cyanomethyl)-1-azetidinecarboxylic acid 1,1-dimethylethyl ester;1-Azetidinecarboxylic acid, 3-(cyanomethyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB21871670
- Molecular Formula
- C10H16N2O2
- Formula Weight
- 196.25
- MOL File
- 142253-58-5.mol
1-Boc-3-(cyanomethyl)azetidine Property
- Boiling point:
- 310.1±15.0 °C(Predicted)
- Density
- 1.089
- storage temp.
- 2-8°C
- pka
- -2.33±0.40(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B812513
- Product name
- tert-Butyl3-(cyanomethyl)azetidine-1-carboxylate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 6946AA
- Product name
- 1-Boc-3-(Cyanomethyl)azetidine
- Packaging
- 250mg
- Price
- $181
- Updated
- 2021/12/16
- Product number
- CHM0167389
- Product name
- 1-BOC-3-(CYANOMETHYL)AZETIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.93
- Updated
- 2021/12/16
- Product number
- A380163
- Product name
- tert-Butyl3-(cyanomethyl)azetidine-1-carboxylate
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- A380163
- Product name
- tert-Butyl3-(cyanomethyl)azetidine-1-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
1-Boc-3-(cyanomethyl)azetidine Chemical Properties,Usage,Production
Synthesis
1153949-11-1
142253-58-5
The general procedure for the synthesis of tert-butyl 3-(cyanomethyl)azetidine-1-carboxylate from tert-butyl 3-(cyanomethyl)azetidine-1-carboxylate was as follows: 2.60 g (13.9 mmol, 1.0 eq.) of tert-butyl 3-(cyanomethyl)azetidine-1-carboxylate was dissolved in 130 mL of methanol, 513 mg (0.48 mmol, 0.036 eq.) of 10% palladium/carbon catalyst (containing 50% water). The reaction mixture was stirred at room temperature for 2 hours under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford 2.63 g (13.3 mmol, 98% yield) of tert-butyl 3-(cyanomethyl)azetidine-1-carboxylate. The product was characterized by 1H NMR (400 MHz, chloroform-d) with the following chemical shifts δ [ppm]: 1.47 (s, 9H), 2.66 (d, J = 7.07 Hz, 2H), 2.83-2.93 (m, 1H), 3.71 (dd, J = 9.09, 5.05 Hz, 2H), 4.15 (t, J = 8.59 Hz, 2H).
References
[1] Patent: WO2016/41925, 2016, A1. Location in patent: Page/Page column 254; 255
1-Boc-3-(cyanomethyl)azetidine Preparation Products And Raw materials
Raw materials
Preparation Products
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