Amino Tadalafil

ChemicalBook > CAS DataBase List > Amino Tadalafil

Product Name: Amino Tadalafil
CAS No.: 385769-84-6
Chemical Name: Amino Tadalafil
Synonyms: Amino Tadanafil;Amino Tadalafil;Amino Tadalafil USP/EP/BP;Tadalafil N-Desmethyl N-Amino;Tadalafil N-Desmethyl N-Amino Impurity;Amino Tadalafil solution in Methanol, 100μg/mL;(6R,12aR)-2-amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-he...;Best Male Enhancement Drugs 99% Amino Tadalafil powder China manufacturer;(6R,12aR)-2-Amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione;(6R,12aR)-2-Amino-6-(benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-1,4-dione
CBNumber: CB21872910
Molecular Formula: C21H18N4O4
Formula Weight: 390.39
MOL File: 385769-84-6.mol

Less

Amino Tadalafil Property

Melting point:: 280-282°C
Boiling point:: 678.9±65.0 °C(Predicted)
Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 16.70±0.40(Predicted)
color: White to Off-White
InChI: InChI=1S/C21H18N4O4/c22-24-9-18(26)25-15(21(24)27)8-13-12-3-1-2-4-14(12)23-19(13)20(25)11-5-6-16-17(7-11)29-10-28-16/h1-7,15,20,23H,8-10,22H2/t15-,20-/m1/s1
InChIKey: VUKJGAVIWMPOOJ-FOIQADDNSA-N
SMILES: N1C2=C(C=CC=C2)C2C[C@]3([H])C(=O)N(N)CC(=O)N3[C@H](C3=CC=C4OCOC4=C3)C1=2
CAS DataBase Reference: 385769-84-6

Less

Safety

Safety Statements: 24/25
HS Code: 29339900

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 20876
Product name: Amino Tadalafil
Purity: ≥98%
Packaging: 5mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 20876
Product name: Amino Tadalafil
Purity: ≥98%
Packaging: 10mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 20876
Product name: Amino Tadalafil
Purity: ≥98%
Packaging: 50mg
Price: $335
Updated: 2024/03/01

Cayman Chemical

Product number: 20876
Product name: Amino Tadalafil
Purity: ≥98%
Packaging: 100mg
Price: $547
Updated: 2024/03/01

Usbiological

Product number: 002553
Product name: Amino Tadalafil
Packaging: 5mg
Price: $418
Updated: 2021/12/16

Less

Amino Tadalafil Chemical Properties,Usage,Production

Description

Amino tadalafil is an analog of tadalafil , a potent inhibitor of phosphodiesterase 5 with applications in several conditions, including erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction. Amino tadalafil has been detected as an illegal adulterant in a dietary supplement marketed for “tonic effect.”

Chemical Properties

White Solid

Uses

Amino Tadalafil is a drug analog of Tadalafil that used to treatment of male erectile dysfunction drugs.

Mechanism of action

Amino tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5).PDE5, an enzyme found primarily in the smooth muscle of the corpus cavernosum, selectively cleaves and degrades cGMP to 5′-GMP. PDE5 inhibitors are similar in structure to cGMP and they competitively bind to PDE5 and inhibit cGMP hydrolysis, thus enhancing the effects of NO, resulting in prolonging an erection.

in vitro

amino-tadalafil is a structural analogue of tadalafil, the active pharmaceutical ingredient in cialis, a prescription drug approved in the us for treatment of erectile dysfunction (ed). similarly, there have also been reports of herbal or dietary supplements being adulterated with designer ed analogues such as amino-tadalafil [1].

in vivo

in rats treated with both melatonin and tadalafil, the recoveries were more pronounced than in rats given either melatonin or tadalafil alone. the icp/mean arterial pressure value in vehicle-treated rats was significantly higher than in the control group, while in the tadalafil- and tadalafil + melatonin-treated groups have returned this value had returned to control levels. in addition, as an individual treatment, and especially when combined with tadalafil, melatonin prevented spinal cord injury (sci)-induced oxidative damage to cavernosal tissues and restored ed, most likely due to its anti-oxidant effects [2].

References

[1] hadwiger me, trehy ml, ye w, moore t, allgire j, westenberger b. identification of amino-tadalafil and rimonabant in electronic cigarette products using high pressure liquid chromatography with diode array and tandem mass spectrometric detection. j chromatogr a. 2010 nov 26;1217(48):7547-55.
[2] tavuk u hh, sener te, tinay i, akbal c, er ahin m, cevik o, cadirci s, reiter rj, sener g. melatonin and tadalafil treatment improves erectile dysfunction after spinal cord injury in rats. clin exp pharmacol physiol. 2014 apr;41(4):309-16.

Amino Tadalafil Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Amino Tadalafil Suppliers

Canada 2 China 146 India 3 United Kingdom 1 United States 8 Global 160

Hubei Haiyue Biotechnology Co., Ltd

Tel: 15926453367
Email: haiyue1682022@163.com
Country: China
ProdList: 251
Advantage: 58

Guangzhou Xucheng Biotechnology Co., Ltd

Tel: 16539527651
Email: 2432687429@qq.com
Country: China
ProdList: 30
Advantage: 58

Xianning Shen Lan Biomedical Research and Development Co., Ltd.

Tel: 18171815831
Email: 1341138380@qq.com
Country: China
ProdList: 2769
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

China Nobel Chem Co., Limited

Tel: +86(0)21 60484900
Fax: +86(0)21 60484900
Country: China
ProdList: 764
Advantage: 50

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 17982
Advantage: 56

DONGGUAN AOME BIOTECHNOLOGY CO.,LTD

Tel: 13790132747
Fax: 0769-87053745
Email: 2784729268@qq.com
Country: China
ProdList: 49
Advantage: 50

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9798
Advantage: 50

Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-58362220 15250997978
Fax: 025-58362220
Email: 1511893459@qq.com
Country: China
ProdList: 7715
Advantage: 55

Alta Scientific Co., Ltd.

Tel: 022-6537-8550 15522853686
Fax: 022-2532-9655
Email: sales@altasci.com.cn
Country: China
ProdList: 4515
Advantage: 55

Shanghai Xiang Xin Industrial Co., Ltd.

Tel: 021-50211651 13651607026
Fax: +86-21-50211651
Email: sales@xxgmpharm.com
Country: China
ProdList: 487
Advantage: 58

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9638
Advantage: 58

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9934
Advantage: 55

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9604
Advantage: 55

Shenzhen Simeiquan Biotechnology Co. Ltd

Tel: 18126413629 0755-23311925 2355327053
Fax: 0755-23311925
Email: abel@ycgmp.com
Country: China
ProdList: 5115
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886750 13927877953
Fax: 0751-2886750
Email: 3005811397@qq.com
Country: China
ProdList: 13353
Advantage: 58

Anhui kuer Bioengineering Co., Ltd

Tel: 0551-65171243 13810511747
Email: kuer@kuerhuaxue.com
Country: China
ProdList: 2997
Advantage: 55

Shanghai Kangman Biological Technology Co., Ltd.

Tel: 18800375331
Fax: 021-50908862
Email: kangmansales@163.com
Country: China
ProdList: 7580
Advantage: 55

Taian Jiaye Biotechnology Co.Ltd

Tel: 13127280945
Email: 285424065@qq.com
Country: China
ProdList: 9980
Advantage: 55

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-28967200 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9506
Advantage: 60

Aikon International Limited

Tel: 025-66113011 18112977050
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16028
Advantage: 58

Hefei Yaogu Biological Technology Co., Ltd.

Tel: 0086-0551-62993905
Fax: 0086-0551-62993905
Email: info@hxygmall.com
Country: China
ProdList: 3374
Advantage: 58

Shandong Fengtai Biotechnology Co., Ltd.

Tel: 0531-0531-82066716 15662658391
Fax: 0531-82066716
Email: 528732991@qq.com
Country: China
ProdList: 1022
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 13028896684
Email: sales@rrkchem.com
Country: China
ProdList: 55827
Advantage: 58

SHANDONG ZHI SHANG CHEMICAL CO.LTD

Tel: +86 18953170293
Fax: +86 0531-67809011
Email: sales@sdzschem.com
Country: China
ProdList: 2931
Advantage: 58

Hebei Mojin Biotechnology Co., Ltd

Tel: +8613288715578
Email: sales@hbmojin.com
Country: China
ProdList: 12455
Advantage: 58

Shijiazhuang Gantuo Biotechnology Co., Ltd

Tel: +8613373514458
Email: gantuo02@cngantuo.com
Country: China
ProdList: 218
Advantage: 58

ANHUI WITOP BIOTECH CO., LTD

Tel: +8615255079626
Email: eric@witopchemical.com
Country: China
ProdList: 23556
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: 0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25363
Advantage: 58

Shanghai Biolang Biotechnology Co., Ltd.

Tel: +86-15970428662 +86-13397199602
Fax: +8613397199602
Email: Niky@biolang.cn
Country: China
ProdList: 518
Advantage: 58

ShanDong Look Chemical Co.,Ltd.

Tel: +8617653113219
Email: sales01@sdlookchemical.com
Country: China
ProdList: 2739
Advantage: 58

sgtlifesciences pvt ltd

Tel: +8617013299288
Email: dj@sgtlifesciences.com
Country: China
ProdList: 12382
Advantage: 58

Wuhan Golt Biotech Co., Ltd.

Tel: +8615389281203
Email: maria@goltbiotech.com
Country: China
ProdList: 980
Advantage: 58

Hong Kong Excellence Biotechnology Co., Ltd.

Tel: +86-86-18838029171 +8618126314766
Fax: wickrme：chemical888
Email: ada@sh-teruiop.com
Country: China
ProdList: 893
Advantage: 58

Hebei Qige Biological Technology Co. Ltd

Tel: +86 +8618733132031
Country: CHINA
ProdList: 1313
Advantage: 58

Hebei Zhanyao Biotechnology Co. Ltd

Tel: 15369953316 +8615369953316
Email: admin@zhanyaobio.com
Country: China
ProdList: 2136
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10523
Advantage: 58

Zhuoer Chemical Co., Ltd

Tel: 02120970332; +8613524231522
Fax: +86-21-58816016
Email: sales@zhuoerchem.com
Country: China
ProdList: 3015
Advantage: 58

Baoji Guokang Bio-Technology Co., Ltd.

Tel: 0917-3909592 13892490616
Fax: 09173909592
Email: gksales1@gk-bio.com
Country: China
ProdList: 9338
Advantage: 58

Shijiazhuang Erche Biotechnology Co., Ltd

Tel: 8613343119830 13343119830
Fax: QQ: 956730943
Email: info07@byyq-cn.com
Country: CHINA
ProdList: 397
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 28965
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-89586680 +86-18192503167
Fax: +86-29-88380327
Email: 1026@dideu.com
Country: China
ProdList: 9197
Advantage: 58

Shanghai UCHEM Inc.

Tel: +862156762820 +86-13564624040
Email: sales@myuchem.com
Country: China
ProdList: 6710
Advantage: 58

Hubei Ipure Biology Co., Ltd

Tel: +8613367258412
Fax: 18062427325
Email: ada@ipurechemical.com
Country: China
ProdList: 10326
Advantage: 58

Hebei Bonster Technology Co.,Limited

Tel: +8613315996897
Fax: 0086-13315996897
Email: bsterltd.wendy@gmail.com
Country: China
ProdList: 796
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28180
Advantage: 58

Hubei Moco Chemical Co., Ltd.

Tel: 18627756402
Fax: QQ：3001051413
Email: 3001051413@qq.com
Country: China
ProdList: 10009
Advantage: 58

Less

View Lastest Price from Amino Tadalafil manufacturers

CONTIDE BIOTECH CO.,LTD

Product: Amino Tadalafil 385769-84-6
Price: US $0.00/G
Min. Order: 1G
Purity: 99
Supply Ability: 20
Release date: 2024-04-12

Shaanxi Franta Biotechnology Co., Ltd

Product: Amino Tadalafil 385769-84-6
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 1000kg
Release date: 2024-03-28

Shaanxi Franta Biotechnology Co., Ltd

Product: Amino Tadalafil 385769-84-6
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 1000kg
Release date: 2024-03-29

385769-84-6, Amino TadalafilRelated Search:

(1S,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester D(+)-Tryptophan Tadalafil iMpurity B Tadalafil KetolactaM (1R,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester (1R,3R)-2-acetyl-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro- 1H-pyrido[3,4-b]indole-3-carboxylate 1,1'-Ethylidenebis(tryptophan) (1S,3R)-1-Benzo[1,3]dioxol-5-yl-2-(2-chloro-acetyl)-2,3,4,9-tetrahydro-1H-b-carboline-3-carboxylic Acid Methyl Ester N-Octyl Nortadalafil Tadalafil EP Impurity 2-Hydroxypropyl Nortadalafil (1S,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester Vardenafil hydrochloride Carteolol hydrochloride Tadalafil TRIMETHYLSULFOXONIUM BROMIDE vardenafil tadalafi

Amino Tadalafil

(6R,12aR)-2-Amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Amino Tadalafil (6R,12Ar)-2-Amino-6-(1,3-Benzodioxol-5-Yl)-2,3,6,7,12,12A-Hexahydropyrazino[1',2':1,6]Pyrido[3,4-B]Indole-1,4-Dione

Amino Tadanafil

(6R,12aR)-2-Amino-6-(benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-1,4-dione

(6R,12aR)-2-amino-6-(benzo[d][1,3]dioxol-5-yl)-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione

Best Male Enhancement Drugs 99% Amino Tadalafil powder China manufacturer

Tadalafil N-Desmethyl N-Amino Impurity

Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, 2-amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-, (6R,12aR)-

Amino Tadalafil solution in Methanol, 100μg/mL

Amino Tadalafil USP/EP/BP

(6R,12aR)-2-amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-he...

Tadalafil N-Desmethyl N-Amino

385769-84-6

Drug Analogues

Intermediates & Fine Chemicals

Pharmaceuticals