N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide

Product Name: N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide
CAS No.: 313480-47-6
Chemical Name: N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide
Synonyms: I S-1.76;IGS-1.76, 10 mM in DMSO;N-(Benzo[d]thiazol-2-yl)-3,3-diphenylpropanamide;Benzenepropanamide, N-2-benzothiazolyl-β-phenyl-;N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide;NCS-1,Ric8a,IGS 1.76,PPI,inhibit,IGS1.76,IGS-1.76,Inhibitor
CBNumber: CB21893317
Molecular Formula: C22H18N2OS
Formula Weight: 358.46
MOL File: 313480-47-6.mol

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N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide Property

storage temp.: Store at -20°C
solubility: DMSO : 250 mg/mL (697.43 mM; Need ultrasonic)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide Chemical Properties,Usage,Production

Biological Activity

IGS-1.76 efficiently inhibits the human NCS-1/Ric8a complex. IGS-1.76 shows a significantly increased affinity for hNCS-1 and is able to modulate the hNCS-1/Ric8a interaction efficiently[1]. IGS-1.76 is a Drosophila NCS-1/IGS-1.76 complex inhibitor[1].

References

[1]. Carlos Roca, et al. Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators. J Med Chem. 2018 Jul 26;61(14):5910-5921.

N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide Suppliers

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313480-47-6, N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamideRelated Search:

N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide

Benzenepropanamide, N-2-benzothiazolyl-β-phenyl-

N-(Benzo[d]thiazol-2-yl)-3,3-diphenylpropanamide

NCS-1,Ric8a,IGS 1.76,PPI,inhibit,IGS1.76,IGS-1.76,Inhibitor

I S-1.76

IGS-1.76, 10 mM in DMSO

313480-47-6