ChemicalBook > CAS DataBase List > 3-AMINO-3-[3-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID

3-AMINO-3-[3-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID

Product Name
3-AMINO-3-[3-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID
CAS No.
143438-91-9
Chemical Name
3-AMINO-3-[3-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID
Synonyms
RARECHEM AK HW 0018;3-TrifluoroMethyl-DL-b-phenylalanine;3-[3-(TRIFLUOROMETHYL)PHENYL]-BETA-ALANINE;(R)-1-(4-chloro-2-fluorophenyl)propan-1-amine;Benzenepropanoic acid, β-amino-3-(trifluoromethyl)-;3-AMINO-3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID;3-AMINO-3-[3-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID;DL-3-Amino-3-(3-trifluoromethylphenyl)propanoic acid;DL-3-AMINO-3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID;(RS)-3-Amino-3-(3-trifluoromethylphenyl)-propionic acid
CBNumber
CB2203250
Molecular Formula
C10H10F3NO2
Formula Weight
233.19
MOL File
143438-91-9.mol
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3-AMINO-3-[3-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID Property

Melting point:
210-212°C
Boiling point:
295.2±40.0 °C(Predicted)
Density 
1.361±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
3.58±0.10(Predicted)
Appearance
White to light yellow Solid
CAS DataBase Reference
143438-91-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2922498590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A631295
Product name
3-Amino-3-(3-trifluoromethylphenyl)propanoicAcid
Packaging
1g
Price
$140
Updated
2021/12/16
AK Scientific
Product number
W3125
Product name
3-Amino-3-[3-(trifluoromethyl)phenyl]-propanoicacid
Packaging
5g
Price
$266
Updated
2021/12/16
Matrix Scientific
Product number
045107
Product name
3-Amino-3-[3-(trifluoromethyl)phenyl]-propanoic acid
Purity
>95%
Packaging
500mg
Price
$362
Updated
2021/12/16
SynQuest Laboratories
Product number
4857-3-75
Product name
3-Amino-3-[3-(trifluoromethyl)phenyl]propanoic acid
Packaging
1g
Price
$365
Updated
2021/12/16
Matrix Scientific
Product number
045107
Product name
3-Amino-3-[3-(trifluoromethyl)phenyl]-propanoic acid
Purity
>95%
Packaging
1g
Price
$454
Updated
2021/12/16
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3-AMINO-3-[3-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID Chemical Properties,Usage,Production

Synthesis

141-82-2

454-89-7

143438-91-9

1. malonic acid (298.82 g, 2.872 mol), ammonium formate (362.14 g, 5.743 mol), and 3-(trifluoromethyl)benzaldehyde (500 g, 2.873 mol) were mixed in 1000 mL of ethanol. 2. The mixture was heated and refluxed for 12 h. 3. Upon completion of the reaction, ethanol was removed by evaporation. 4. The residue was milled with 2500 The residue was ground with 2500 mL of acetone. 5. The solid was collected by filtration and dried to give 3-amino-3-[3-(trifluoromethyl)phenyl]propanoic acid (255 g) as a white solid. 6. The product was confirmed by NMR hydrogen spectroscopy (400 MHz, AcOH-d4): δ 7.87-7.81 (m, 2H), 7.74 (d, 1H, J = 7.6 Hz), 7.66- 7.62 (m, 1H), 7.66- 7.62 (m, 1H). 7.62 (m, 1H), 4.98 (br.s, 1H), 3.36 (dd, 1H, J = 16.0, 8.0 Hz), 3.13 (dd, 1H, J = 17.6, 5.6 Hz). 7. Mass spectrometry analysis revealed: m/z 234 (M + 1).

References

[1] Journal of Heterocyclic Chemistry, 2017, vol. 54, # 4, p. 2440 - 2446
[2] Patent: WO2017/144183, 2017, A1. Location in patent: Page/Page column 65

3-AMINO-3-[3-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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3-AMINO-3-[3-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID Suppliers

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143438-91-9, 3-AMINO-3-[3-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACIDRelated Search:

3-AMINO-3-[3-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID (S)-3-AMINO-3-[4-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID (R)-3-AMINO-3-[3-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID (S)-3-AMINO-3-[2-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID 3-AMINO-3-[2-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID (R)-3-AMINO-3-[4-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID (R)-3-AMINO-3-[2-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID (2S)-2-amino-3-[3-(trifluoromethyl)phenyl]propanoic acid (S)-3-AMINO-3-[3-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID 3-AMINO-3-[4-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID 3-(3-Trifluoromethylphenyl)propionic acid FMOC-(S)-3-AMINO-3-(3-TRIFLUOROMETHYL-PHENYL)-PROPANOIC ACID (R)-BOC-3-(TRIFLUOROMETHYL)-BETA-PHE-OH FMOC-(R)-3-AMINO-3-(3-TRIFLUOROMETHYL-PHENYL)-PROPANOIC ACID 3-AMINO-3-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID 3-[(tert-butoxycarbonyl)amino]-3-[3-(trifluoromethyl)phenyl]propanoic acid (S)-BOC-3-(TRIFLUOROMETHYL)-BETA-PHE-OH 3-AMINO-3-(4-CHLORO-3-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID

  • RARECHEM AK HW 0018
  • DL-3-AMINO-3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID
  • DL-3-AMINO-3-(3-TRIFLUOROMETHYL-PHENYL)-PHENYLPROPIONIC ACID
  • 3-[3-(TRIFLUOROMETHYL)PHENYL]-BETA-ALANINE
  • 3-AMINO-3-[3-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID
  • 3-AMINO-3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID
  • DL-3-Amino-3-(3-trifluoromethylphenyl)propanoic acid
  • 3-TrifluoroMethyl-DL-b-phenylalanine
  • 3-(1-Amino-2-carboxyethyl)benzotrifluoride, 3-Amino-3-[3-(trifluoromethyl)phenyl]propionic acid
  • (RS)-3-Amino-3-(3-trifluoromethylphenyl)-propionic acid
  • Benzenepropanoic acid, β-amino-3-(trifluoromethyl)-
  • (R)-1-(4-chloro-2-fluorophenyl)propan-1-amine
  • 143438-91-9
  • B-Amino